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The Effect of Somatization on Gastrointestinal and Extraintestinal Symptoms of IBS
      01/26/04 03:26 PM
HeatherAdministrator

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The Effect of Somatization on Gastrointestinal and Extraintestinal Symptoms of IBS

Lin Chang, MD

Psychosocial disturbances (eg, depression, anxiety, stressful life events, and somatization) are commonly found in patients with IBS, particularly those with more severe symptoms or those seen in tertiary referral populations.[17] In addition, extraintestinal symptoms, such as fatigue, myalgias, sleep, and sexual disturbances are also frequently reported by patients with IBS.[18] The association between psychosocial factors and extraintestinal symptoms in IBS is not well understood.

Crowell and colleagues[19] studied the influence of somatization (measured by the psychological questionnaire SCL-90R) on gastrointestinal and extraintestinal symptoms in IBS consulters in 133 consecutive Rome-positive IBS patients. Abdominal pain, pain sites, and upper and lower gastrointestinal symptoms were reported to a significantly greater degree by patients with IBS with elevated scores for somatization. In addition, somatization scores significantly correlated with the presence of extraintestinal symptoms such as chronic fatigue, temporomandibular joint, low back pain, and both anxiety and panic attacks. Patients with IBS with elevated scores for somatization also had reduced functional abilities and QOL.

The study authors concluded that IBS is a heterogeneous disorder in which the presence of multiple gastrointestinal and nongastrointestinal symptoms could be a marker for psychologic factors that could play a role in the etiology, healthcare utilization, and treatment outcome of IBS. It is still not known whether the increased prevalence of extraintestinal symptoms is due to coexistent psychologic disorders that may share similar symptoms with IBS, or if the gastrointestinal, extraintestinal, and psychologic symptoms all result from a shared central pathophysiologic mechanism underlying IBS. However, this study supports the concept that somatization is an important confounding factor that should be considered when evaluating or interpreting data on gastrointestinal, extraintestinal, and other psychologic symptoms in IBS.

Summary
These IBS symptom-related studies reiterate the challenges of diagnosing IBS and of understanding the underlying clinical relevance and pathophysiologic mechanisms of specific symptoms, including altered bowel habits, other gastrointestinal symptoms, and extraintestinal symptoms. Future studies that can help establish a biologic marker(s) for IBS would be important in overcoming these challenges.

References
Wells NE, Hahn BA, Whorwell PJ. Clinical economics review: irritable bowel syndrome. Aliment Pharmacol Ther. 1997;11:1019-1030.
Gralnek IM, Hays RD, Kilbourne A, Naliboff B, Mayer EA. The impact of irritable bowel syndrome on health-related quality of life. Gastroenterology. 2000;119:654-60.
Frank L, Kleinman L, Rentz A, Ciesla G, Kim JJ, Zacker C. Health-related quality of life associated with irritable bowel syndrome: comparison with other chronic diseases. Clin Ther. 2002;24:675-689.
Hungin P, Chang L, Barghout V, Kahler K. The impact of IBS on absenteeism and work productivity: United States and eight European countries. Am J Gastroenterol. 2003;98:S227. [Abstract # 687]
Sandler RS, Everhart JE, Donowitz M, et al. The burden of selected digestive diseases in the United States. Gastroenterology. 2002;122:1500-1151.
Dean BB, Aguilar D, Barghout V, Kahler K, Groves D, Ofman JJ. Impairments in worker productivity and health-related quality of life among employees with irritable bowel syndrome: Does bowel habit predominance make a difference? Am J Gastroenterol. 98:S233, 2003. [Abstract # 703]
Palsson OS, Whitehead WE, Barghout V, et al. IBS severity and health-related quality of life improve with age in women but not in men. Am J Gastroenterol. 98:S272, 2003. [Abstract #818]
Gore M, Frech F, Tai K-S, Nguyen AB, Shetzline MA. Burden of illness in patients with irritable bowel syndrome with constipation. Am J Gastroenterol. 2003;98:S219. [Abstract # 662]
Whitehead WE, Cheskin LJ, Heller BR, et al. Evidence for exacerbation of irritable bowel syndrome during menses. Gastroenterology. 1990;98:1485-1489.
Kennedy TM, Jones RH. Epidemiology of cholecystectomy and irritable bowel syndrome in a UK population. Br J Surg. 2000;87:1568-1563.
Longstreth GF, Yao JF. Irritable bowel syndrome and surgery in HMO health examinees. Am J Gastroenterol. 2003;98:S265. [Abstract #797]
Ganguly R, Barghout V, Pannicker S, Martin BC. Prevalence of GI related surgical procedures among Medicaid eligible patients with and without irritable bowel syndrome. Am J Gastroenterol. 2003 98:S274-S275. [Abstract # 825]
Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Muller-Lissner SA. Functional bowel disorders and functional abdominal pain. Gut. 1999; 45(suppl II):1143-1147.
Dean BB, Aguilar D, Barghout V, Kahler K, Groves D, Ofman JJ. Identifying IBS patients using Rome II symptom criteria: 3- or 12-month reporting? Am J Gastroenterol. 2003;98:S235-S236. [Abstract # 711]
Gore M, Frech F, Nguyen AB, Tai K-S, Shetzline MA. Development of a new symptom-based algorithm for classifying IBS patients into IBS subgroups. Am J Gastroenterol. 2003;98:S219. [Abstract # 663]
Locke GR, Zinsmeister AR, Melton LJ, Talley NJ. Who is an "alternator?" -- a population based study. Am J Gastroenterol. 2003;98:S275. [Abstract # 828]
Drossman DA, Camilleri M, Mayer EA, Whitehead WE. AGA technical review on irritable bowel syndrome. Gastroenterology. 2002;123:2108-2131.
Whitehead WE, Palsson O, Jones KR. Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications? Gastroenterology. 2002;122:1140-1156.
Crowell MD, Schettler VA, Lacy BE, Jones MP, Olden KW, Whitehead WE. Impact of somatization on gastrointestinal (GI) and extra-intestinal comorbidities in IBS. Am J Gastroenterol. 2003;98:S271-S272. [Abstract #816]
Muller-Lissner SA, Fumagalli I, Bardhan KD, et al. Tegaserod, a 5-HT(4) receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation. Aliment Pharmacol Ther. 2001;15:1655-1666.
Camilleri M, Northcutt AR, Kong S, Dukes GE, McSorley D, Mangel AW. Efficacy and safety of alosetron in women with irritable bowel syndrome: A randomised placebo-controlled trial. Lancet. 2000;355:1035-1040.
Dunger-Baldauf C, Nyhlin H, Rueegg P, Wagner A. Subject's global assessment of satisfactory relief as a measure to assess treatment effect in clinical trials in irritable bowel syndrome (IBS). Am J Gastroenterol. 2003;98:S269. [Abstract #809]
Prather CM, Camilleri M, Zinsmeister AR, McKinzie S, Thomforde G. Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome. Gastroenterology. 2000;118:463-468.
Talley N, Kamm M, Mueller-Lissner S, et al. Tegaserod is effective in relieving the multiple symptoms of constipation: Results from a 12-week multinational study in patients with chronic constipation. Am J Gastroenterol. 2003;98:S269-S270. [Abstract #810]
Kariv R, Tiomny E, Grenshpon R, Waisman G, Halpern Z. Low-dose naltrexone for the treatment of irritable bowel syndrome. Am J Gastroenterol. 2003 98:S268. [Abstract #805]

http://www.medscape.com/viewarticle/463421

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