All Boards >> Irritable Bowel Syndrome Research Library

View all threads Posts     Flat     Threaded

Fecal transplantation may not improve IBS symptoms
      08/22/18 02:03 PM
HeatherAdministrator

Reged: 12/09/02
Posts: 7788
Loc: Seattle, WA

Top News in Gastroenterology
Fecal transplantation may not improve IBS symptoms

Reuters Health News ' August 21, 2018

Fecal microbiota transplantation (FMT) increases microbial diversity but does not improve symptoms in patients with irritable bowel syndrome (IBS), according to results from a placebo-controlled study.

The microbiome of the gastrointestinal tract is thought to play a role in IBS, and FMT has yielded benefits in other conditions where altered microbial diversity is important.

Dr. Andreas Munk Petersen from Copenhagen University Hospital Hvidovre, in Denmark, and colleagues assessed the effects of FMT in a double-blind, placebo-controlled trial of 52 adult patients with moderate-to-severe IBS. FMT (or placebo) was administered as 25 capsules every morning for 12 days, preceded by a bowel cleansing corresponding to that performed before colonoscopy.

At 3 months, the placebo group showed a significantly greater improvement in IBS disease severity (as measured by the IBS-severity scoring system, or IBS-SSS) than did the FMT group (mean improvement, 125.71 points vs 52.45 points; P=0.012).

Eight patients in the FMT group (36.4%) experienced at least 50-point improvements in IBS-SSS score compared with 19 patients in the placebo group (79.2%) at 3 months, the researchers report in Gut, online August 4.

On average, patients in the placebo group experienced significantly greater improvement in quality of life (16.50 points), compared with patients in the FMT group (7.22 points).

Patients receiving FMT capsules had increases in microbial biodiversity to that matching the fecal donors, whereas placebo patients remained indistinguishable from their pretreatment state.

Microbial diversity did not correlate with IBS-SSS scores.

"No clinical trials have compared FMT delivery routes in IBS, and further trials are needed to determine if a change in delivery route could have an effect on FMT treatment success in these patients," the researchers note.

"There is no evidence for FMT providing symptomatic benefit in patients with IBS in this trial," they conclude. "Although our study shows a better effect of a bowel cleansing than a bowel cleansing followed by FMT treatment on IBS symptoms, we still believe that FMT can be the way forward."

Dr. Stefano Di Bella of the University Hospital of Trieste, Italy, who recently reviewed the role of FMT in inflammatory bowel disease, told Reuters Health by email, "FMT is not a panacea. Increased fecal microbial diversity is not always a synonym of intestinal 'health.'"

"We do not know the pathogenesis of IBS; therefore, the results are not really surprising," said Dr. Di Bella, who was not involved in the study. "The concept of 'dysbiosis' is too generic to be associated with IBS."

He added, "The results of this study could be a starting point to 're-think' the IBS pathogenesis."

Dr. Petersen did not respond to a request for comments.

"Will Boggs, MD

https://www.mdlinx.com/gastroenterology/top-medical-news/article/2018/08/21/7542281


--------------------
Heather is the Administrator of the IBS Message Boards. She is the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

Print     Remind Me     Notify Moderator    

Entire thread
* General IBS / Bowel Dysfunction
HeatherAdministrator
07/14/03 01:56 PM
* Postcolonoscopy Antibiotics Linked With IBS
HeatherAdministrator
06/02/20 02:14 PM
* Expanding Role of Fecal Microbiota Transplants: Hope or Hype?
HeatherAdministrator
12/30/19 03:03 PM
* Constipation in Older Adults Improved With Biofeedback
HeatherAdministrator
11/06/19 03:24 PM
* Patients with IBS Diarrhea, IBS Constipation, find their lives impacted in different ways
HeatherAdministrator
08/15/19 04:32 PM
* New, noninvasive test for bowel diseases
HeatherAdministrator
06/28/19 04:42 PM
* Oh, Poop! Study Links Pets to Higher IBS Risk for Owners
HeatherAdministrator
05/21/19 03:05 PM
* Microbiome science may deliver more effective, personalized treatment to children with IBS
HeatherAdministrator
04/23/19 03:23 PM
* Altered gut microbiota as a possible cause of IBS - Harmful bacteria increased in IBS, protective bacteria decreased.
HeatherAdministrator
04/09/19 01:59 PM
* 5 conditions that can cause uncontrolled bowel movements
HeatherAdministrator
02/28/19 03:01 PM
* Exercise boosts well-being by improving gut health
HeatherAdministrator
02/20/19 02:42 PM
* Scientists find that hundreds of gut bacteria are electric
HeatherAdministrator
09/19/18 01:06 PM
* Fecal transplantation may not improve IBS symptoms
HeatherAdministrator
08/22/18 02:03 PM
* Fecal Microbiota Transplant Relieves IBS With Predominant Bloating
HeatherAdministrator
07/25/18 12:46 PM
* April is IBS Awareness Month: 10 recent advances in research, diagnostics
HeatherAdministrator
04/16/18 02:05 PM
* Bacteria can trigger stomach cancer
HeatherAdministrator
08/25/17 04:11 PM
* Fecal microbiota transplantation improved symptoms and quality of life in patients with IBS
HeatherAdministrator
05/09/17 01:28 PM
* Autism symptoms improve after fecal transplant, small study finds
HeatherAdministrator
01/26/17 02:54 PM
* Microbiota and arthritis: correlations or cause?
HeatherAdministrator
02/19/16 01:09 PM
* Takeda, Enterome to collaborate on microbiome-based drugs for IBD, IBS, other GI disorders
HeatherAdministrator
01/11/16 03:21 PM
* Risk factors for IBS in military include stress, infectious gastroenteritis
HeatherAdministrator
01/11/16 03:19 PM
* Risk Factors ID'd for Fecal Transplant Failure
HeatherAdministrator
10/26/15 03:06 PM
* Blood Test Helps Some IBS Patients Get Firm Diagnosis
HeatherAdministrator
10/15/15 10:51 AM
* Differences in IBS patients' microbiota more significant in feces vs. mucosa
HeatherAdministrator
09/28/15 02:14 PM
* Higher reported cat dander sensitization rate may explain asthma prevalence in IBS patients
HeatherAdministrator
09/14/15 03:32 PM
* Picky Eaters Have Extra Helpings of Anxiety, Depression
HeatherAdministrator
08/05/15 03:42 PM
* Prediabetes Patients Have Fewer Gut Bugs
HeatherAdministrator
03/09/15 03:08 PM
* FDA approves Eclipse System for fecal incontinence in women
HeatherAdministrator
02/23/15 01:35 PM
* Fecal transplant leads to sudden obesity
HeatherAdministrator
02/23/15 01:24 PM
* New Criteria Would Double Fibromyalgia Cases
HeatherAdministrator
02/10/15 04:17 PM
* 2014 FDA approvals in gastroenterology
HeatherAdministrator
01/12/15 03:36 PM
* Colonoscopy prep affects gut bacteria
HeatherAdministrator
01/07/15 03:58 PM
* The Bile-IBS Link
HeatherAdministrator
12/15/14 03:18 PM
* Ineffective Pain Meds in IBS Patients Related to Immune System Changes
HeatherAdministrator
12/09/14 11:34 AM
* Volatile organic compounds accurate biomarkers for IBS in children
HeatherAdministrator
10/27/14 01:59 PM
* Researchers develop, validate eight GI symptom scales
HeatherAdministrator
10/07/14 02:17 PM
* Sleep Measures Can Help Predict Next-Day Symptoms in IBS Female Patients
HeatherAdministrator
09/17/14 02:27 PM
* Domestic violence may trigger irritable bowel syndrome
HeatherAdministrator
09/17/14 02:15 PM
* All IBS subtypes have similar symptom severity
HeatherAdministrator
09/05/14 03:50 PM
* Gut microbiome can diagnose colorectal cancer?
HeatherAdministrator
08/12