All Boards >> Irritable Bowel Syndrome Research Library


Reged: 12/09/02
Posts: 7679
Loc: Seattle, WA
Delays in gluten introduction, onset of celiac disease in at-risk infants linked
      10/07/14 02:23 PM

Delays in gluten introduction, onset of celiac disease in at-risk infants linked
October 3, 2014

Among infants at-risk for celiac disease, delayed introduction of dietary gluten was associated with delayed onset of disease, according to new research data.

To explicate the correlation between age of introduction to dietary gluten and risk for celiac disease (CD), Elena Lionetti, MD, PhD, department of pediatrics at the University of Catania, Italy, and colleagues conducted a multicenter, prospective intervention trial (CELIPREV) between 2003 and 2008. They compared outcomes of infants with familial risk for CD who either had early or delayed introduction of gluten to their diet.
Elena Lionetti, MD, PhD

Elena Lionetti

Participants were randomly assigned to introduce gluten at age 6 months (group A) or 12 months (group B), and daily intake was assessed by a questionnaire. HLA genotype was determined at 15 months, CD serology was performed at 15, 24 and 36 months and at 5, 8 and 10 years. Patients who were seropositive for CD also had biopsy performed.

Among children (n=707) still participating at 36 months (group A, n=379; 49.6% girls; median age at study completion, 7.9 years), 553 had standard-risk or high-risk HLA genotypes and completed the study. At 2 years 16% of group A had CD autoimmunity and 12% had overt CD, compared with 7% and 5%, respectively, of group B (P=.002; P=.01). CD autoimmunity differences were no longer significant at 5 years (21% vs. 20%), nor was overt disease (16% vs. 16%). At 10 years risk for CD autoimmunity was 37.9% in high-risk HLA genotypes compared with 19.2% for standard-risk genotypes (HR=0.5; 95% CI, 0.3-0.7). Risk for overt disease was 25.8% among high-risk HLA genotypes vs. 15.8% for standard-risk genotypes (HR=0.6; 95% CI, 0.3-1).

“Postponing the introduction of gluten had two potentially positive consequences,” the researchers concluded. “First, it delayed the development of celiac disease, which might reduce the negative effect of the disease on vulnerable organs such as the brain. Second, it reduced the prevalence, albeit nonsignificantly, of celiac disease autoimmunity at any age among children carrying the high-risk HLA genotype.”
Jonas F. Ludvigsson, MD, PhD

Jonas F. Ludvigsson

In an accompanying editorial, Jonas F. Ludvigsson, MD, PhD, from Karolinska Institutet and Örebro University Hospital, Sweden, and Peter H.R. Green, MD, from the Celiac Disease Center at Columbia University, College of Physicians and Surgeons, wrote that this and related studies “will change the conceptual landscape” of celiac disease. The CELIPREV researchers, they said, found “first, the timing of introduction of gluten in high-risk children does not appear to influence the development of CD in childhood. Second, there is no evidence that the duration of breast-feeding or the maintenance of breast-feeding when gluten is introduced influences the risk of CD later in life. Finally, the only identified risk factor for CD later in life is the HLA genotype.”

For more information:

Lionetti E. N Engl J Med. 2014;371:1295-1303.

Ludvigsson JF. N Engl J Med. 2014;371:1341-1343.

Heather is the Administrator of the IBS Message Boards. She’s the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

Post Extras Print Post   Remind Me!     Notify Moderator

Entire thread
Subject Posted by Posted on
* Celiac / Gluten Intolerance HeatherAdministrator 07/14/03 01:59 PM
. * Fructans Suspect in Non-Celiac Gluten Sensitivity HeatherAdministrator   03/19/18 02:44 PM
. * Relatives, spouses of celiac disease patients at risk for autoimmune disease HeatherAdministrator   07/09/15 03:39 PM
. * Children with silent celiac HeatherAdministrator   06/19/15 03:06 PM
. * Delays in gluten introduction, onset of celiac disease in at-risk infants linked HeatherAdministrator   10/07/14 02:23 PM
. * Evidence points to Monsanto Roundup as culprit in rise of gluten intolerance & IBS HeatherAdministrator   02/19/14 01:30 PM
. * New approach to celiac testing identifies more at risk HeatherAdministrator   08/30/13 12:11 PM
. * Is a Gluten-Free Diet Right for You? HeatherAdministrator   08/16/13 02:15 PM
. * FDA Defines ‘Gluten-free’ for Food Labels HeatherAdministrator   08/07/13 10:49 AM
. * Tooth damage may be a sign of celiac disease HeatherAdministrator   06/11/13 03:47 PM
. * The Gluten-Free Vegetarian — Not to Worry, the Food Options Are Plentiful HeatherAdministrator   04/17/13 12:01 PM
. * Gluten-Free, Whether You Need It or Not HeatherAdministrator   02/08/13 11:27 AM
. * Non-celiac gluten sensitivity less common than celiac disease HeatherAdministrator   10/31/12 11:32 AM
. * Most Cases of Non-Responsive Celiac Disease Due to Ongoing Gluten Consumption HeatherAdministrator   06/15/12 03:08 PM
. * The good and the bad of going gluten free HeatherAdministrator   06/15/12 01:18 PM
. * Weird!! Patients with Non-celiac Gluten Sensitivity Report More Symptoms than Those with Celiac Disease HeatherAdministrator   06/15/12 01:12 PM
. * Irritable Bowel Syndrome and Gluten Sensitivity Without Celiac Disease HeatherAdministrator   05/17/12 12:13 PM
. * Celiac disease is more common in older adults HeatherAdministrator   04/23/12 01:40 PM
. * Celiac Disease on the Rise in U.S. - from sanitation and hygiene? HeatherAdministrator   08/24/11 02:41 PM
. * Birth Month Seems to Be Linked to Celiac Disease HeatherAdministrator   05/09/11 11:50 AM
. * More People May Benefit From Going Gluten-Free HeatherAdministrator   05/09/11 11:44 AM
. * Gluten Causes Gastrointestinal Symptoms in Subjects Without Celiac Disease HeatherAdministrator   01/13/11 01:01 PM
. * Celiac Disease Is Increasing Worldwide HeatherAdministrator   08/04/10 11:57 AM
. * Gluten intolerance versus celiac disease HeatherAdministrator   04/14/10 10:27 AM
. * Celiac disease may strike elderly, too HeatherAdministrator   03/11/10 01:19 PM
. * Gene links to celiac disease may help drug search HeatherAdministrator   03/11/10 12:57 PM
. * Genetic links to celiac disease identified HeatherAdministrator   03/05/10 02:36 PM
. * People on gluten-free diets benefit from oats HeatherAdministrator   03/05/10 12:23 PM
. * Between Celiac Disease and Irritable Bowel Syndrome HeatherAdministrator   03/05/10 11:49 AM
. * Study confirms four-fold increase in wheat gluten disorder HeatherAdministrator   07/22/09 01:15 PM
. * Effect of gluten-free diet and co-morbidity of irritable bowel syndrome-type symptoms on celiac patients HeatherAdministrator   03/18/09 05:46 PM
. * Gluten-Free Diet in Patients Diagnosed With Diarrhea-Predominant Irritable Bowel Syndrome HeatherAdministrator   07/17/07 11:18 AM
. * Non-Toxic Wheat May Be an Answer to Celiac Disease HeatherAdministrator   10/28/05 11:57 AM
. * Babies at Celiac Disease Risk Should Wait for Wheat HeatherAdministrator   06/20/05 04:24 PM
. * Relief for celiac patients HeatherAdministrator   06/05/05 05:48 PM
. * Gastrointestinal Motility Disturbances in Celiac Disease. HeatherAdministrator   09/12/04 03:27 PM
. * Celiac Disease: Where We Are and Where We Are Going HeatherAdministrator   06/27/04 01:58 PM
. * No Link Apparent Between IBS and Celiac Disease HeatherAdministrator   04/27/04 09:01 PM
. * Oats Safe for Celiac in Children HeatherAdministrator   04/26/04 01:08 PM
. * Celiac disease is a risk factor for schizophrenia HeatherAdministrator   02/24/04 02:13 PM
. * Against the grain: The growing awareness of celiac sprue HeatherAdministrator   08/12/03 12:12 PM
. * Celiac disease: fertility and pregnancy. HeatherAdministrator   07/15/03 06:14 PM
. * Celiac disease and spontaneous abortion HeatherAdministrator   07/15/03 06:12 PM
. * Is it necessary to screen for celiac disease in postmenopausal osteoporotic women? HeatherAdministrator   07/15/03 06:09 PM
. * Celiac Disease: More Common Than You Think HeatherAdministrator   07/14/03 04:15 PM
. * High prevalence of small intestinal bacterial overgrowth in celiac patients HeatherAdministrator   07/14/03 03:04 PM

Extra information
0 registered and 8 anonymous users are browsing this forum.

Moderator:  Heather 

      You cannot post until you login
      You cannot reply until you login
      HTML is enabled
      UBBCode is enabled

Thread views: 122053

Jump to

| Privacy statement Help for IBS Home

UBB.threads™ 6.2

Shop For IBS Here!