All Boards >> Irritable Bowel Syndrome Research Library

View all threads Posts     Flat     Threaded

Most Cases of Non-Responsive Celiac Disease Due to Ongoing Gluten Consumption
      06/15/12 03:08 PM
HeatherAdministrator

Reged: 12/09/02
Posts: 7795
Loc: Seattle, WA

Most Cases of Non-Responsive Celiac Disease Due to Ongoing Gluten Consumption

By Jefferson Adams
Published 06/4/2012

Celiac.com 06/04/2012 - Non-responsive celiac disease is very much what it sounds like: celiac disease where symptoms seem to resist treatment and continue even in the face of a gluten-free diet.

Photo: CC--return the sunA team of researchers recently set out to look for the most likely causes of persistent symptoms in celiac disease patients on a gluten-free diet.

The research team included David H. Dewar, Suzanne C. Donnelly, Simon D. McLaughlin, Matthew W. Johnson, H. Julia Ellis, and Paul J. Ciclitira. They are variously affiliated with King's College London, Division of diabetes and Nutritional Sciences, Department of Gastroenterology, and The Rayne Institute at St. Thomas' Hospital in London.

Their goal for the study was to investigate all patients referred to our center with non-responsive celiac disease (NRCD), to establish a cause for their continued symptoms.

For their study, the research team assessed all non-responsive celiac disease who were referred to their gastroenterology center over an 18-mo period.

They then established the etiology of ongoing symptoms for these patients. For all patients, the team established a thorough case history and conducted a complete examination with routine blood work including tissue transglutaminase antibody measurement.

Additionally, each patient was examined by a specialist gastroenterology dietician to try to spot any gaps in their diets, or any hidden sources of gluten consumption.

When possible, the team conducted a follow-up small intestinal biopsy, and compared the results against the biopsies from the referring hospital.

Patients with persistent symptoms received colonoscopy, lactulose hydrogen breath testing, pancreolauryl testing and a computed tomography scan of the abdomen.

The team monitored patient progress over a minimum of two year period. Overall, the team looked at 112 patients with non-responsive celiac disease. They determined that twelve of those did not actually have celiac disease. Of the remaining 100 patients, nearly half, 45%, were not adequately following a strict gluten-free diet. Of these, 24 (53%) were found to be accidentally consuming gluten, while 21 (47%) admitted to not faithfully following a gluten-free diet.

Microscopic colitis was found in 12% and small bowel bacterial overgrowth in 9%. refractory celiac disease was found in 9%. Three of these were diagnosed with intestinal lymphoma. After 2 years, 78 patients remained well, eight had continuing symptoms, and four had died.

In most cases of non-responsive celiac disease, the team found a reversible cause can be found in 90%. In the vast number of those cases, continued consumption of gluten was the main cause.

The team is proposing the use of an algorithm for further investigation of the matter.

Source:

World J Gastroenterol. 2012 Mar 28;18(12):1348-56.

http://www.celiac.com/articles/22914/1/Most-Cases-of-Non-Responsive-Celiac-Disease-Due-to-Ongoing-Gluten-Consumption/Page1.html

--------------------
Heather is the Administrator of the IBS Message Boards. She is the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

Print     Remind Me     Notify Moderator    

Entire thread
* Celiac / Gluten Intolerance
HeatherAdministrator
07/14/03 01:59 PM
* Antibiotics Before Age 1 Tied to Celiac Disease Risk
HeatherAdministrator
03/13/19 01:34 PM
* Fructans Suspect in Non-Celiac Gluten Sensitivity
HeatherAdministrator
03/19/18 02:44 PM
* Relatives, spouses of celiac disease patients at risk for autoimmune disease
HeatherAdministrator
07/09/15 03:39 PM
* Children with silent celiac
HeatherAdministrator
06/19/15 03:06 PM
* Delays in gluten introduction, onset of celiac disease in at-risk infants linked
HeatherAdministrator
10/07/14 02:23 PM
* Evidence points to Monsanto Roundup as culprit in rise of gluten intolerance & IBS
HeatherAdministrator
02/19/14 01:30 PM
* New approach to celiac testing identifies more at risk
HeatherAdministrator
08/30/13 12:11 PM
* Is a Gluten-Free Diet Right for You?
HeatherAdministrator
08/16/13 02:15 PM
* FDA Defines ‘Gluten-free’ for Food Labels
HeatherAdministrator
08/07/13 10:49 AM
* Tooth damage may be a sign of celiac disease
HeatherAdministrator
06/11/13 03:47 PM
* The Gluten-Free Vegetarian — Not to Worry, the Food Options Are Plentiful
HeatherAdministrator
04/17/13 12:01 PM
* Gluten-Free, Whether You Need It or Not
HeatherAdministrator
02/08/13 11:27 AM
* Non-celiac gluten sensitivity less common than celiac disease
HeatherAdministrator
10/31/12 11:32 AM
* Most Cases of Non-Responsive Celiac Disease Due to Ongoing Gluten Consumption
HeatherAdministrator
06/15/12 03:08 PM
* The good and the bad of going gluten free
HeatherAdministrator
06/15/12 01:18 PM
* Weird!! Patients with Non-celiac Gluten Sensitivity Report More Symptoms than Those with Celiac Disease
HeatherAdministrator
06/15/12 01:12 PM
* Irritable Bowel Syndrome and Gluten Sensitivity Without Celiac Disease
HeatherAdministrator
05/17/12 12:13 PM
* Celiac disease is more common in older adults
HeatherAdministrator
04/23/12 01:40 PM
* Celiac Disease on the Rise in U.S. - from sanitation and hygiene?
HeatherAdministrator
08/24/11 02:41 PM
* Birth Month Seems to Be Linked to Celiac Disease
HeatherAdministrator
05/09/11 11:50 AM
* More People May Benefit From Going Gluten-Free
HeatherAdministrator
05/09/11 11:44 AM
* Gluten Causes Gastrointestinal Symptoms in Subjects Without Celiac Disease
HeatherAdministrator
01/13/11 01:01 PM
* Celiac Disease Is Increasing Worldwide
HeatherAdministrator
08/04/10 11:57 AM
* Gluten intolerance versus celiac disease
HeatherAdministrator
04/14/10 10:27 AM
* Celiac disease may strike elderly, too
HeatherAdministrator
03/11/10 01:19 PM
* Gene links to celiac disease may help drug search
HeatherAdministrator
03/11/10 12:57 PM
* Genetic links to celiac disease identified
HeatherAdministrator
03/05/10 02:36 PM
* People on gluten-free diets benefit from oats
HeatherAdministrator
03/05/10 12:23 PM
* Between Celiac Disease and Irritable Bowel Syndrome
HeatherAdministrator
03/05/10 11:49 AM
* Study confirms four-fold increase in wheat gluten disorder
HeatherAdministrator
07/22/09 01:15 PM
* Effect of gluten-free diet and co-morbidity of irritable bowel syndrome-type symptoms on celiac patients
HeatherAdministrator
03/18/09 05:46 PM
* Gluten-Free Diet in Patients Diagnosed With Diarrhea-Predominant Irritable Bowel Syndrome
HeatherAdministrator
07/17/07 11:18 AM
* Non-Toxic Wheat May Be an Answer to Celiac Disease
HeatherAdministrator
10/28/05 11:57 AM
* Babies at Celiac Disease Risk Should Wait for Wheat
HeatherAdministrator
06/20/05 04:24 PM
* Relief for celiac patients
HeatherAdministrator
06/05/05 05:48 PM
* Gastrointestinal Motility Disturbances in Celiac Disease.
HeatherAdministrator
09/12/04 03:27 PM
* Celiac Disease: Where We Are and Where We Are Going
HeatherAdministrator
06/27/04 01:58 PM
* No Link Apparent Between IBS and Celiac Disease
HeatherAdministrator
04/27/04 09:01 PM
* Oats Safe for Celiac in Children
HeatherAdministrator
04/26/04 01:08 PM
* Celiac disease is a risk factor for schizophrenia
HeatherAdministrator
02/24/04 02:13 PM
* Against the grain: The growing awareness of celiac sprue
HeatherAdministrator
08/12/03 12:12 PM
* Celiac disease: fertility and pregnancy.
HeatherAdministrator
07/15/03 06:14 PM
* Celiac disease and spontaneous abortion
HeatherAdministrator
07/15/03 06:12 PM
* Is it necessary to screen for celiac disease in postmenopausal osteoporotic women?
HeatherAdministrator
07/15/03 06:09 PM
* Celiac Disease: More Common Than You Think
HeatherAdministrator
07/14/03 04:15 PM
* High prevalence of small intestinal bacterial overgrowth in celiac patients
HeatherAdministrator
07/14/03 03:04 PM

Extra information
0 registered and 5 anonymous users are browsing this forum.

Moderator:  Heather 



Permissions
      You cannot post until you login
      You cannot reply until you login
      HTML is enabled
      UBBCode is enabled

Thread views: 151153

Jump to

| Privacy statement Help for IBS Home

*
UBB.threads™ 6.2


McAfee SECURE sites help keep you safe from identity theft, credit card fraud, spyware, spam, viruses and online scams

HelpForIBS.com BBB Business Review