Antacids increase risk of pneumonia
01/14/11 04:35 PM
|
|
|
|
Heather
Reged: 12/09/02
Posts: 7799
Loc: Seattle, WA
|
|
|
Use of acid-suppressive drugs and risk of pneumonia: systematic review and meta-analysis
Chun-Sick Eom, Christie Y. Jeon, Ju-Won Lim, Eun-Geol Cho, Sang Min Park and Kang-Sook Lee
From the Department of Family Medicine (Eom, Lim, Cho, Park), Seoul National University Hospital, Seoul, Republic of Korea; the Department of Epidemiology (Jeon), Harvard School of Public Health, Boston, USA; and the Department of Preventive Medicine (Lee), College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Dr. Sang Min Park, Department of Family Medicine, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, Republic of Korea. E-mail sangmin.park.snuh@gmail.com
Dr. Kang-Sook Lee, Department of Preventive Medicine, College of Medicine, Catholic University of Korea, 505 Banpo-Dong, Seocho-Gu, Seoul 137-701, Republic of Korea. E-mail leekangs@catholic.ac.kr
Background: Observational studies and randomized controlled trials have yielded inconsistent findings about the association between the use of acid-suppressive drugs and the risk of pneumonia. We performed a systematic review and meta-analysis to summarize this association.
Methods: We searched three electronic databases (MEDLIN E [PubMed], Embase and the Cochrane Library) from inception to Aug. 28, 2009. Two evaluators independently extracted data. Because of heterogeneity, we used randomeffects meta-analysis to obtain pooled estimates of effect.
Results: We identified 31 studies: five case–control studies, three cohort studies and 23 randomized controlled trials. A meta-analysis of the eight observational studies showed that the overall risk of pneumonia was higher among people using proton pump inhibitors (adjusted odds ratio [OR] 1.27, 95% confidence interval [CI] 1.11–1.46, I2 90.5%) and histamine2 receptor antagonists (adjusted OR 1.22, 95% CI 1.09–1.36, I2 0.0%). In the randomized controlled trials, use of histamine2 receptor antagonists was associated with an elevated risk of hospital-acquired pneumonia (relative risk 1.22, 95% CI 1.01–1.48, I2 30.6%).
Interpretation: Use of a proton pump inhibitor or histamine2 receptor antagonist may be associated with an increased risk of both community- and hospital-acquired pneumonia. Given these potential adverse effects, clinicians should use caution in prescribing acid-suppressive drugs for patients at risk.
http://www.cmaj.ca/cgi/content/abstract/cmaj.092129v1
--------------------
Heather is the Administrator of the IBS Message Boards. She is the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!
Print
Remind Me
Notify Moderator
|
|
Posts
