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Gender-related differences in prepulse inhibition of startle in irritable bowel syndrome       03/11/10 01:48 PM Edit Reply Quote Heather Reged: 12/09/02 Posts: 7799 Loc: Seattle, WA Biol Psychol. 2010 Mar 1. Gender-related differences in prepulse inhibition of startle in irritable bowel syndrome (IBS). Kilpatrick LA, Ornitz E, Ibrahimovic H, Treanor M, Craske M, Nazarian M, Mayer EA, Naliboff BD. Center for Neurobiology of Stress, David Geffen School of Medicine, UCLA, United States; Department of Medicine and Physiology, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, United States. Alterations in central networks involved in the regulation of arousal, attention, and cognition may be critical for irritable bowel syndrome (IBS) symptom maintenance and exacerbation. Differential sensitivities in these networks may underlie sex differences noted in IBS. The current study examined prepulse inhibition (PPI), a measure of sensorimotor gating, in male and female IBS patients. Relationships between PPI and symptom severity were examined, as well as potential menstrual status effects. Compared to healthy controls, male IBS patients had significantly reduced PPI; whereas female IBS patients (particularly naturally cycling women) had significantly enhanced PPI suggesting hypervigilance. Considering previously demonstrated sex-related differences in perceptual and brain imaging findings in IBS patients, the current findings suggest that different neurobiological mechanisms underlie symptom presentation in male and female IBS patients. Compromised filtering of information in male IBS patients may be due to compromised top down (prefrontal, midcingulate) control mechanisms while increased attention to threat due to increased limbic and paralimbic circuits may be characteristic of female IBS patients. Copyright © 2010. Published by Elsevier B.V. PMID: 20193731 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/pubmed/20193731 -------------------- Heather is the Administrator of the IBS Message Boards. She is the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook! Print     Remind Me     Notify Moderator

Entire thread Gender / Hormones Heather 07/14/03 01:57 PM Pain management in women is often overlooked and ineffective Heather 02/16/15 04:42 PM Women, Hormones and IBS Heather 03/11/14 02:09 PM Fennel is an effective herbal drug for menstrual pain Heather 08/27/13 11:29 AM Constipation and Risk of Cardiovascular Disease among Postmenopausal Women Heather 08/03/11 03:58 PM Differences in Gastrointestinal Symptoms According to Gender in Rome II Positive IBS and Dyspepsia Heather 03/11/10 01:51 PM Gender-related differences in prepulse inhibition of startle in irritable bowel syndrome Heather 03/11/10 01:48 PM No evidence of sex differences in heritability of irritable bowel syndrome Heather 03/31/08 11:36 AM Acupuncture for the treatment of pain from a gender perspective. Heather 03/31/08 11:27 AM The menstrual cycle and its effect on inflammatory bowel disease and irritable bowel syndrome Heather 11/07/07 02:35 PM Irritable Bowel Syndrome Is More Common in Women Regardless of the Menstrual Phase Heather 11/07/07 02:31 PM Pelvic floor dysfunction and IBS in patients with interstitial cystitis. Heather 10/10/07 12:33 PM Women with IBS have abnormal pain modulation Heather 10/10/07 12:01 PM Anxiety or Depression with IBS Affects More Women Than Men Heather 09/24/07 11:31 AM Colonoscopies more difficult and painful for women and people with IBS Heather 09/24/07 11:22 AM Role of gender and early childhood in constipation Heather 09/13/07 11:09 AM Changes in Bowel Function: Pregnancy and the Puerperium Heather 03/01/07 01:39 PM Drugs for gastrointestinal disorders in pregnant women. Heather 05/13/06 03:20 PM Functional bowel disorders in patients with pelvic organ prolapse and incontinence Heather 12/08/05 12:10 PM Sex specific alterations in autonomic function among patients with irritable bowel syndrome Heather 11/12/05 01:16 PM Women With Interstitial Cystitis at Risk for Irritable Bowel Syndrome and Depression Heather 09/22/05 04:39 PM Women and Men Perceive Pain Differently Heather 09/13/05 12:55 PM Overlapping Conditions in Women With Irritable Bowel Syndrome Heather 04/24/05 03:58 PM Bowel habit in irritable bowel syndrome in women: Defining an alternator Heather 04/10/05 06:18 PM Recognition and treatment of irritable bowel syndrome among women with chronic pelvic pain Heather 03/28/05 12:18 PM Irritable bowel syndrome, chronic pelvic inflammatory disease and endometriosis Heather 02/19/05 05:43 PM A gene for diarrhoea-predominant IBS in women? Heather 11/28/04 02:21 PM Autonomic Cardiovascular Responses Are Impaired in Women With Irritable Bowel Syndrome Heather 09/12/04 03:41 PM Abdominal Bloating: Relation to Rectal Hypersensitivity and Menstrual Cycle Heather 06/27/04 01:55 PM Catching Colon Cancer in Women Can Be Tough Heather 04/13/04 03:32 PM Women More Sensitive to Pain Than Men Heather 04/13/04 03:31 PM Gender Differences In Brain Response To IBS Pain Heather 11/18/03 03:32 PM After Menopause, IBS Lessens in Women Heather 11/04/03 03:34 PM Is hormone replacement therapy associated with an increased risk of irritable bowel syndrome? Heather 07/25/03 11:43 AM Sleep disturbance influences gastrointestinal symptoms in women with irritable bowel syndrome. Heather 07/18/03 01:00 PM Symptoms across the menstrual cycle in women with irritable bowel syndrome. Heather 07/18/03 12:58 PM Does a physically active lifestyle improve symptoms in women with irritable bowel syndrome? Heather 07/18/03 12:54 PM Relation between hysterectomy and the irritable bowel Heather 07/18/03 11:48 AM Diagnosis and management of IBS, constipation, and diarrhea in pregnancy. Heather 07/18/03 11:47 AM Physician perception of IBS management in women and men. Heather 07/15/03 06:38 PM Gender issues in the management of IBD and IBS Heather 07/15/03 06:11 PM Gender differences in gut transit Heather 07/15/03 06:07 PM Bowel dysfunction in postmenopausal women. Heather 07/15/03 06:04 PM Irritable Bowel Syndrome Worse During Periods Heather 07/14/03 03:25 PM Sex-related differences in IBS patients: Central processing of visceral stimuli Heather 07/14/03 02:40 PM

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