All Boards >> Irritable Bowel Syndrome Research Library

View all threads Posts     Flat     Threaded

New insights into the pathogenesis and pathophysiology of irritable bowel syndrome
      03/01/07 01:17 PM
HeatherAdministrator

Reged: 12/09/02
Posts: 7788
Loc: Seattle, WA

Digestive and Liver Disease
Volume 39, Issue 3 , March 2007, Pages 201-215

New insights into the pathogenesis and pathophysiology of irritable bowel syndrome

L. Öhmana and M. Simrén, a,

aDepartment of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

Received 11 September 2006; accepted 25 October 2006. Available online 30 January 2007.




Abstract
The pathogenesis and pathophysiology of irritable bowel syndrome is complex and still incompletely known. Potential pathogenetic factors include genes, infectious events, psychological symptoms and other loosely defined environmental factors. Both alterations at the central and peripheral level are thought to contribute to the symptoms of irritable bowel syndrome, including psychosocial factors, abnormal gastrointestinal motility and secretion, and visceral hypersensitivity. Today irritable bowel syndrome is viewed upon as a disorder of dysregulation of the so-called brain–gut axis, involving abnormal function in the enteric, autonomic and/or central nervous systems, with peripheral abnormalities probably dominating in some patients and disturbed central processing of signals from the periphery in others. Lines of evidence also suggest that inflammation within the gastrointestinal tract may be of great importance in at least subgroups of irritable bowel syndrome patients. To conclude, a complex picture of the pathogenesis and pathophysiology of irritable bowel syndrome is emerging, with interactions between several different alterations resulting in the divergent symptom pattern in these patients.

Keywords: Brain–gut axis; Gastrointestinal motility; Inflammation; Irritable bowel syndrome; Serotonin; Visceral hypersensitivity

Abbreviations: ANS, autonomic nervous system; CNS, central nervous system; EC, enterochromaffin; ENS, enteric nervous system; fMRI, functional magnetic resonance imaging; GI, gastrointestinal; HPA, hypothalamic-pituitary-adrenal; IBD, inflammatory bowel disease; IBS, irritable bowel syndrome; Ig, immunoglobulin; IL, interleukin; NMDA, N-methyl-d-aspartic acid; PET, positron emission tomography; SERT, serotonin reuptake transporter; TNF, tumour necrosis factor; Treg, regulatory T cells; TNBS, trinitrobenzenesulfonic acid



Corresponding author at: Section of Gastroenterology & Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, S-41345 Gothenburg, Sweden. Tel.: +46 31 342 10 00; fax: +46 31 82 21 52.




http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7582-4MY0V07-2&_user=10&_coverDate=03%2F31%2F2007&_rdoc=2&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%2312914%232007%23999609996%23643896%23FLA%23display%23Volume)&_cdi=12914&_sort=d&_docanchor=&view=c&_ct=97&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=298bc3220d6ab80646176c1921fbf292

--------------------
Heather is the Administrator of the IBS Message Boards. She is the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

Print     Remind Me     Notify Moderator    

Entire thread
* General IBS / Bowel Dysfunction
HeatherAdministrator
07/14/03 01:56 PM
* Postcolonoscopy Antibiotics Linked With IBS
HeatherAdministrator
06/02/20 02:14 PM
* Expanding Role of Fecal Microbiota Transplants: Hope or Hype?
HeatherAdministrator
12/30/19 03:03 PM
* Constipation in Older Adults Improved With Biofeedback
HeatherAdministrator
11/06/19 03:24 PM
* Patients with IBS Diarrhea, IBS Constipation, find their lives impacted in different ways
HeatherAdministrator
08/15/19 04:32 PM
* New, noninvasive test for bowel diseases
HeatherAdministrator
06/28/19 04:42 PM
* Oh, Poop! Study Links Pets to Higher IBS Risk for Owners
HeatherAdministrator
05/21/19 03:05 PM
* Microbiome science may deliver more effective, personalized treatment to children with IBS
HeatherAdministrator
04/23/19 03:23 PM
* Altered gut microbiota as a possible cause of IBS - Harmful bacteria increased in IBS, protective bacteria decreased.
HeatherAdministrator
04/09/19 01:59 PM
* 5 conditions that can cause uncontrolled bowel movements
HeatherAdministrator
02/28/19 03:01 PM
* Exercise boosts well-being by improving gut health
HeatherAdministrator
02/20/19 02:42 PM
* Scientists find that hundreds of gut bacteria are electric
HeatherAdministrator
09/19/18 01:06 PM
* Fecal transplantation may not improve IBS symptoms
HeatherAdministrator
08/22/18 02:03 PM
* Fecal Microbiota Transplant Relieves IBS With Predominant Bloating
HeatherAdministrator
07/25/18 12:46 PM
* April is IBS Awareness Month: 10 recent advances in research, diagnostics
HeatherAdministrator
04/16/18 02:05 PM
* Bacteria can trigger stomach cancer
HeatherAdministrator
08/25/17 04:11 PM
* Fecal microbiota transplantation improved symptoms and quality of life in patients with IBS
HeatherAdministrator
05/09/17 01:28 PM
* Autism symptoms improve after fecal transplant, small study finds
HeatherAdministrator
01/26/17 02:54 PM
* Microbiota and arthritis: correlations or cause?
HeatherAdministrator
02/19/16 01:09 PM
* Takeda, Enterome to collaborate on microbiome-based drugs for IBD, IBS, other GI disorders
HeatherAdministrator
01/11/16 03:21 PM
* Risk factors for IBS in military include stress, infectious gastroenteritis
HeatherAdministrator
01/11/16 03:19 PM
* Risk Factors ID'd for Fecal Transplant Failure
HeatherAdministrator
10/26/15 03:06 PM
* Blood Test Helps Some IBS Patients Get Firm Diagnosis
HeatherAdministrator
10/15/15 10:51 AM
* Differences in IBS patients' microbiota more significant in feces vs. mucosa
HeatherAdministrator
09/28/15 02:14 PM
* Higher reported cat dander sensitization rate may explain asthma prevalence in IBS patients
HeatherAdministrator
09/14/15 03:32 PM
* Picky Eaters Have Extra Helpings of Anxiety, Depression
HeatherAdministrator
08/05/15 03:42 PM
* Prediabetes Patients Have Fewer Gut Bugs
HeatherAdministrator
03/09/15 03:08 PM
* FDA approves Eclipse System for fecal incontinence in women
HeatherAdministrator
02/23/15 01:35 PM
* Fecal transplant leads to sudden obesity
HeatherAdministrator
02/23/15 01:24 PM
*