All Boards >> Irritable Bowel Syndrome Research Library

View all threads Posts     Flat     Threaded

Probiotics in women with IBS
      02/04/07 04:17 PM
HeatherAdministrator

Reged: 12/09/02
Posts: 7785
Loc: Seattle, WA

Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome.

Am J Gastroenterol. 2006; 101(7):1581-90 (ISSN: 0002-9270)
Whorwell PJ; Altringer L; Morel J; Bond Y; Charbonneau D; O'Mahony L; Kiely B; Shanahan F; Quigley EM
Department of Medicine, University of Manchester, Manchester, UK.

BACKGROUND: Probiotic bacteria exhibit a variety of properties, including immunomodulatory activity, which are unique to a particular strain. Thus, not all species will necessarily have the same therapeutic potential in a particular condition. We have preliminary evidence that Bifidobacterium infantis 35624 may have utility in irritable bowel syndrome (IBS). OBJECTIVES: This study was designed to confirm the efficacy of the probiotic bacteria B. infantis 35624 in a large-scale, multicenter, clinical trial of women with IBS. A second objective of the study was to determine the optimal dosage of probiotic for administration in an encapsulated formulation. METHODS: After a 2-wk baseline, 362 primary care IBS patients, with any bowel habit subtype, were randomized to either placebo or freeze-dried, encapsulated B. infantis at a dose of 1 x 10(6), 1 x 10(8), or 1 x 10(10), cfu/mL for 4 wk. IBS symptoms were monitored daily and scored on to a 6-point Likert scale with the primary outcome variable being abdominal pain or discomfort. A composite symptom score, the subject's global assessment of IBS symptom relief, and measures of quality of life (using the IBS-QOL instrument) were also recorded. RESULTS: B. infantis 35624 at a dose of 1 x 10(8) cfu was significantly superior to placebo and all other bifidobacterium doses for the primary efficacy variable of abdominal pain as well as the composite score and scores for bloating, bowel dysfunction, incomplete evacuation, straining, and the passage of gas at the end of the 4-wk study. The improvement in global symptom assessment exceeded placebo by more than 20% (p < 0.02). Two other doses of probiotic (1 x 10(6) and 1 x 10(10)) were not significantly different from placebo; of these, the 1 x 10(10) dose was associated with significant formulation problems. No significant adverse events were recorded. CONCLUSIONS: B. infantis 35624 is a probiotic that specifically relieves many of the symptoms of IBS. At a dosage level of 1 x 10(8) cfu, it can be delivered by a capsule making it stable, convenient to administer, and amenable to widespread use. The lack of benefits observed with the other dosage levels of the probiotic highlight the need for clinical data in the final dosage form and dose of probiotic before these products should be used in practice.

http://www.medscape.com/medline/abstract/16863564

--------------------
Heather is the Administrator of the IBS Message Boards. She is the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

Print     Remind Me     Notify Moderator    

Entire thread
* Herbs, Probiotics, and Supplements
HeatherAdministrator
07/14/03 01:53 PM
* Medical cannabis: Promising uses supported by medical data
HeatherAdministrator
03/05/19 12:58 PM
* Glutamine supplements improve symptoms of postinfectious IBS-Diarrhea
HeatherAdministrator
08/22/18 02:35 PM
* Review article: the physiological effects and safety of peppermint oil and its efficacy in irritable bowel syndrome
HeatherAdministrator
01/26/18 12:06 PM
* Vitamin D deficiency in children and adults with IBS
HeatherAdministrator
04/07/17 03:18 PM
* Trial of aloe vera for irritable bowel syndrome
HeatherAdministrator
05/27/15 02:44 PM
* Aloe vera in Patients with Irritable Bowel Syndrome
HeatherAdministrator
05/27/15 02:39 PM
* Vitamins and IBS
HeatherAdministrator
03/11/14 02:10 PM
* IBS Quick Tip - Aloe, Senna, and Cascara for IBS?
HeatherAdministrator
09/10/13 11:20 AM
* IBS quick tip -taking a fiber supplements and medications
HeatherAdministrator
08/30/13 11:54 AM
* Fennel is an effective herbal drug for menstrual pain
HeatherAdministrator
08/21/13 05:59 PM
* Probiotic treatments relieve irritable bowel syndrome symptoms in recent study
HeatherAdministrator
01/18/13 02:38 PM
* Probiotics for GI Issues and Obesity - Problems May Take Root in Gut Flora
HeatherAdministrator
05/09/12 01:26 PM
* Probiotics May Prevent Antibiotic Diarrhea
HeatherAdministrator
05/09/12 12:38 PM
* Today Show Recommends Peppermint Oil Caps for IBS
HeatherAdministrator
12/02/11 03:58 PM
* Dr. Oz Recommends Peppermint Oil Capsules
HeatherAdministrator
11/23/11 02:32 PM
* Probiotic Pills Better for IBS than Yogurt
HeatherAdministrator
09/30/11 12:06 PM
* How Peppermint Helps to Relieve Irritable Bowel Syndrome
HeatherAdministrator
04/20/11 12:41 PM
* Zinc for acute diarrhea
HeatherAdministrator
02/10/11 10:18 AM
* Effect of ginger on gastric motility and symptoms of functional dyspepsia
HeatherAdministrator
02/10/11 10:16 AM
* Inulin can cause gastrointestinal discomfort
HeatherAdministrator
07/16/10 03:13 PM
* St. John's Wort Not Helpful For Irritable Bowel Syndrome
HeatherAdministrator
01/08/10 02:19 PM
* Systematic Review and Meta-Analysis: Probiotics in the treatment of Irritable Bowel Syndrome
HeatherAdministrator
02/18/09 02:16 PM
* Probiotic Yogurt Helps Reduce Physical Bloating
HeatherAdministrator
12/16/08 11:40 AM
* Peppermint oil, soluble fiber, and antispasmodics should be first-line treatments
HeatherAdministrator
12/03/08 11:37 AM
* Health Benefits of Probiotic Could Extend Beyond Gastrointestinal System
HeatherAdministrator
08/27/08 12:24 PM
* Acacia establishes prebiotic functionality in healthy human volunteers
HeatherAdministrator
06/19/08 11:54 AM
* Probiotics and prebiotics in irritable bowel syndrome
HeatherAdministrator
06/06/08 09:41 AM
* Gastrointestinal Microbiota in Irritable Bowel Syndrome
HeatherAdministrator
06/05/08 03:56 PM
* Efficacy of Probiotics in Irritable Bowel Syndrome
HeatherAdministrator
05/23/08 11:06 AM
* Probiotics in irritable bowel syndrome
HeatherAdministrator
01/18/08 12:32 PM
* Bacteria: a new player in gastrointestinal motility disorders-infections, bacterial overgrowth, and probiotics
HeatherAdministrator
11/07/07 02:49 PM
* Probiotic-prebiotic treatment for irritable bowel syndrome
HeatherAdministrator
08/28/07 01:29 PM
* Peppermint oil is effective in treating digestive disorders and other conditions including headaches
HeatherAdministrator
06/06/07 11:20 AM
* Probiotics and irritable bowel syndrome
HeatherAdministrator
05/11/07 02:25 PM
* Bacterial flora in irritable bowel syndrome
HeatherAdministrator
05/11/07 02:19 PM
* Peppermint oil capsules in the treatment of irritable bowel syndrome
HeatherAdministrator
04/28/07 10:36 AM
* Probiotics in women with IBS
HeatherAdministrator
02/04/07 04:17 PM
* Comparison of fennel and the drug mefenamic acid on pain intensity of menstrual cramps
HeatherAdministrator
12/01/06 02:27 PM
* Probiotics Effective for Treating Clostridium Difficile Disease and Antibiotic-Associated Diarrhea?
HeatherAdministrator
12/01/06 01:09 PM
* Review of Probiotics for IBD
HeatherAdministrator
07/17/06 02:10 PM
* A review of the bioactivity and potential health benefits of peppermint tea
HeatherAdministrator
07/17/06 12:01 PM
* Probiotics Help Chronic Constipation
HeatherAdministrator
07/05/06 05:40 PM
* Beneficial Bacteria Protect the Gut from Stress
HeatherAdministrator
05/29/06 02:25 PM
* Dietary fibre supplementation with psyllium or Acacia (gum arabic) reduced faecal incontinence
HeatherAdministrator
05/29/06 02:23 PM
* Probiotics and chronic disease
HeatherAdministrator
05/13/06 03:23 PM
* Peppermint Oil May Be "Drug of First Choice" for IBS
HeatherAdministrator
03/16/06 12:45 PM
* Herbal medicines for treatment of irritable bowel syndrome
HeatherAdministrator
02/18/06 12:54 PM
* Peppermint possesses antispasmodic properties
HeatherAdministrator
12/21/05 11:16 AM
* Pharmacological Basis for the Medicinal Use of Ginger in Gastrointestinal Disorders
HeatherAdministrator
12/19/05 04:50 PM
* Probiotic relieves irritable bowel syndrome
HeatherAdministrator
11/12/05 01:04 PM
* Melatonin May Reduce the Pain of Irritable Bowel Syndrome
HeatherAdministrator
10/28/05 11:53 AM
* A probiotic mixture alleviates symptoms in irritable bowel syndrome patients
HeatherAdministrator
09/22/05 04:26 PM
* Interactions Between Commensal Bacteria and Gut Sensorimotor Function
HeatherAdministrator
08/22/05 04:57 PM
* Prebiotic shown to increase bone mineral density
HeatherAdministrator
06/05/05 05:40 PM
* Fiber's New Role in Type 2 Diabetes
HeatherAdministrator
06/05/05 05:28 PM
* "Good" Bacteria Help Irritable Bowel Syndrome as much as Zelnorm and Lotronex
HeatherAdministrator
04/10/05 06:34 PM
* Complementary and Alternative Medicine Use by Patients With Gastrointestinal Diseases.
HeatherAdministrator
01/23/05 04:56 PM
* New evidence supports camomile tea's health benefits
HeatherAdministrator
01/07/05 05:02 PM
* Effectiveness of a symbiotic preparation in irritable bowel syndrome
HeatherAdministrator
11/08/04 04:44 PM
* Probiotic VSL#3 Could Relieve Some Irritable Bowel Abdominal Bloating
HeatherAdministrator
11/08/04 04:04 PM
* Probiotic Improves Postinfective Gut Dysfunction in Animal Model
HeatherAdministrator
10/11/04 04:30 PM
* Probiotics, dead or alive, can relieve gut disease
HeatherAdministrator
08/30/04 02:38 PM
* Prebiotics for improved gut health
HeatherAdministrator
07/11/04 03:15 PM
* Calcium Seems to Protect Against Colorectal Cancer
HeatherAdministrator
06/27/04 02:04 PM
* Safety of aloe a concern
HeatherAdministrator
05/25/04 03:26 PM
* Aloe, cascara sagrada, and senna laxtives can cause cathartic colon
HeatherAdministrator
05/25/04 03:24 PM
* Gut Check - The bacteria in your intestines are welcome guests
HeatherAdministrator
05/10/04 01:33 PM
* Probiotics and Prebiotics in Gastrointestinal Disorders
HeatherAdministrator
04/27/04 08:53 PM
* Yogurt Prevents Antibiotic-Associated Diarrhea
HeatherAdministrator
04/13/04 02:50 PM
* Bacteria Basics - Probiotics for IBS and IBD
HeatherAdministrator
03/30/04 01:56 PM
* Lactobacillus Reduces Irritable Bowel Bloating
HeatherAdministrator
12/01/03 06:06 PM
* Probiotic improves gastrointestinal symptoms in patients with chronic constipation
HeatherAdministrator
12/01/03 06:00 PM
* Aloe plant's IBS healing powers tested
HeatherAdministrator
11/18/03 03:42 PM
* Possible Drug Interactions with: Ginger
HeatherAdministrator
10/13/03 01:19 PM
* Hepatoprotective effect of Fennel essential oil
HeatherAdministrator
10/12/03 04:53 PM
* Fennel for the treatment of primary dysmenorrhea
HeatherAdministrator
10/12/03 04:51 PM
* Fennel, intestinal spasms, and infantile colic
HeatherAdministrator
10/12/03 04:48 PM
* Probiotics Significantly Reduce Symptoms of IBS, Ulcerative Colitis
HeatherAdministrator
07/22/03 09:41 PM
* Ginger: history and use for the prevention of nausea, dizziness, and vomiting
HeatherAdministrator
07/22/03 06:52 PM
* Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials.
HeatherAdministrator
07/22/03 06:50 PM
* Alteration of intestinal microflora and reduced IBS bloating and pain
HeatherAdministrator
07/18/03 12:01 PM
* Study on the efficacy of Lactobacillus in patients with irritable bowel syndrome.
HeatherAdministrator
07/18/03 11:42 AM
* Treatment for constipation-predominant IBS using Padma Lax, a Tibetan herbal formula
HeatherAdministrator
07/15/03 11:24 PM
* Ginger for nausea and vomiting in pregnancy
HeatherAdministrator
07/14/03 03:55 PM
* Peppermint-oil capsules in the treatment of IBS: a prospective, randomized trial
HeatherAdministrator
07/14/03 03:51 PM
* Efficacy of Peppermint oil in diarrhea predominant IBS
HeatherAdministrator
08/21/13 05:44 PM
* The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome.
HeatherAdministrator
08/21/13 05:46 PM
* Peppermint oil capsules for the treatment of IBS in children.
HeatherAdministrator
07/14/03 03:49 PM

Extra information
0 registered and 5 anonymous users are browsing this forum.

Moderator:  Heather 



Permissions
      You cannot post until you login
      You cannot reply until you login
      HTML is enabled
      UBBCode is enabled

Thread views: 806471

Jump to

| Privacy statement Help for IBS Home

*
UBB.threads™ 6.2


McAfee SECURE sites help keep you safe from identity theft, credit card fraud, spyware, spam, viruses and online scams

HelpForIBS.com BBB Business Review