All Boards >> Irritable Bowel Syndrome Research Library


Reged: 12/09/02
Posts: 7680
Loc: Seattle, WA
Psychological factors as a predictor of treatment response in patients with heartburn
      03/04/06 12:39 PM

Psychological factors as a predictor of treatment response in patients with heartburn: A pooled analysis of clinical trials

Authors: Wiklund, Ingela1; Carlsson1, Rolf1; Carlsson, Jonas1; Glise, Hans1

Source: Scandinavian Journal of Gastroenterology, Volume 41, Number 3, Number 3/March 2006, pp. 288-293(6)

Objective . A pooled analysis, using data from three prospective, randomized, double-blind, placebo-controlled, clinical studies, was undertaken to determine the relationship between well-being and subsequent clinical response to acid suppressant therapy in 1887 adult patients with reflux symptoms (with/without endoscopically verified erosive esophagitis).

Material and methods . Well-being was assessed at study entry using the Psychological General Well-Being (PGWB) Index. Patients were assessed for complete relief of heartburn (absence of symptoms in the preceding 7 days) after 4 weeks' treatment (omeprazole 10 or 20?mg once daily; ranitidine 150?mg twice daily).

Results . Multiple logistic regression analysis identified baseline PGWB Index total score and anxiety score as independent prognostic indicators of treatment response in endoscopy-positive patients ( n =1333). Thus, the likelihood of achieving complete heartburn relief was impaired by high baseline levels of anxiety or a low total well-being score. In the endoscopy-negative group, high levels of depression and low vitality scores affected treatment response adversely. Furthermore, age (for endoscopy-positive patients only) and body mass index (for endoscopy-negative patients only) showed an association with treatment outcome. Gender seemed to have no prognostic value on treatment outcome.

Conclusions . Patient well-being may be a useful prognostic indicator in patients presenting with reflux symptoms, with a high level of anxiety predicating against a response to acid suppressant therapy, particularly in those with normal endoscopic findings.

Heather is the Administrator of the IBS Message Boards. She’s the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

Post Extras Print Post   Remind Me!     Notify Moderator

Entire thread
Subject Posted by Posted on
* Psychological / Psychiatric HeatherAdministrator 07/14/03 01:50 PM
. * The Impact of Rotating Shift Work on the Prevalence of Irritable Bowel Syndrome in Nurses HeatherAdministrator   03/11/10 01:57 PM
. * Interpersonal communication apprehension, topic avoidance, and the experience of irritable bowel syndrome HeatherAdministrator   07/08/09 12:25 PM
. * Cognitive behavioural model of irritable bowel syndrome - is it your personality? HeatherAdministrator   09/13/07 11:49 AM
. * Psychological factors as a predictor of treatment response in patients with heartburn HeatherAdministrator   03/04/06 12:39 PM
. * A History of Abuse in Community Subjects with Irritable Bowel Syndrome HeatherAdministrator   09/01/05 10:57 AM
. * Psychosocial Factors are Linked to Functional Gastrointestinal Disorders HeatherAdministrator   04/13/04 03:39 PM
. * Psychological factors in the irritable bowel syndrome HeatherAdministrator   02/10/04 02:30 PM
. * Beyond abuse: the association among parenting style, abdominal pain, & somatization in IBS patients HeatherAdministrator   02/10/04 02:27 PM
. * Social learning, affective state and passive coping in irritable bowel syndrome and IBD HeatherAdministrator   02/10/04 01:43 PM
. * Computer game cure for stress related illnesses HeatherAdministrator   11/18/03 03:26 PM
. * Psychopathology in irritable bowel syndrome HeatherAdministrator   08/19/03 01:50 PM
. * The relationship between irritable bowel syndrome and psychiatric illness. HeatherAdministrator   08/02/03 10:34 PM
. * Psychiatric illness, personality traits and the irritable bowel syndrome. HeatherAdministrator   07/18/03 12:27 PM
. * Pattern-Specific Brain Activation and Personalities Seen in IBS HeatherAdministrator   07/14/03 03:12 PM

Extra information
0 registered and 5 anonymous users are browsing this forum.

Moderator:  Heather 

      You cannot post until you login
      You cannot reply until you login
      HTML is enabled
      UBBCode is enabled

Thread views: 59700

Jump to

| Privacy statement Help for IBS Home

UBB.threads™ 6.2

Shop For IBS Here!