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The Genetics of Irritable Bowel Syndrome
      11/12/05 01:10 PM
HeatherAdministrator

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The Genetics of Irritable Bowel Syndrome

doi:10.1016/S1542-3565(05)00184-9
Copyright © 2005 American Gastroenterological Association Published by Elsevier Ltd.
Clinical genomics

The Genetics of Irritable Bowel Syndrome

Yuri A. Saito , Gloria M. Petersená, G. Richard Locke III; and Nicholas J. Talley

Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic and Foundation, Rochester, Minnesota, USA
áDivision of Epidemiology, Mayo Clinic and Foundation, Rochester, Minnesota, USA

Available online 2 November 2005.

Because of the heterogeneity in symptoms and diagnostic findings, patients with irritable bowel syndrome (IBS) remain a challenge to treat and to study. This difficulty stems from lack of understanding of the pathophysiology of this disorder.

Environmental factors likely play an important role in the pathogenesis and clinical manifestations of IBS. Several recent studies suggest a genetic basis for IBS, either in etiology or predicting response to therapy. Because of interest in studying the genetic contributors to this and other functional gastrointestinal disorders, we review the literature on genetic risk factors that might explain the familial clustering of IBS. Familial aggregation studies and twin studies suggest a modest contribution of genetics to the development of IBS. Pharmacogenomic and association studies provide stronger, although far from conclusive, evidence for genetic variants that affect expression of IBS. Together, these studies suggest that a multidisciplinary approach with clinical and psychological tools, epidemiologic methods, and genetic techniques might help elucidate the molecular components leading to the common symptoms of IBS and result in better treatments for those with IBS.



Clinical Gastroenterology and Hepatology
Volume 3, Issue 11 , November 2005, Pages 1057-1065

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7GGW-4HG68V2-C&_user=10&_handle=V-WA-A-W-WC-MsSAYWA-UUW-U-AABBZAEWVD-AABAWUUUVD-VVEZVEUBZ-WC-U&_fmt=summary&_coverDate=11%2F30%2F2005&_rdoc=11&_orig=browse&_srch=%23toc%2320161%232005%23999969988%23609635!&_cdi=20161&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4f28e1b14a3d1abbf03afcce4ac10050


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