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Oral Contraceptives and HRT a Risk Factor for Inflammatory Bowel Disease
      09/13/05 01:22 PM
HeatherAdministrator

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Risk Factors for Inflammatory Bowel Disease in the General Population

L. A. García Rodríguez; A. González-Pérez; S. Johansson; M.-A. Wallander


Background: The aetiology of inflammatory bowel disease remains largely unknown.

Aim: We performed a comprehensive assessment of potential risk factors associated with the occurrence of inflammatory bowel disease.

Methods: We identified a cohort of patients 20–84 years old between 1995 and 1997 registered in the General Practitioner Research Database in the UK. A total of 444 incident cases of IBD were ascertained and validated with the general practitioner. We performed a nested case–control analysis using all cases and a random sample of 10 000 frequency-matched controls.

Results: Incidence rates for ulcerative colitis, Crohn's disease, and indeterminate colitis were 11, 8, and 2 cases per 100 000 person-years, respectively. Among women, we found that long-term users of oral contraceptives were at increased risk of developing UC (OR: 2.35; 95% CI: 0.89–6.22) and CD (OR: 3.15; 95% CI: 1.24–7.99). Similarly, long-term users of HRT had an increased risk of CD (OR: 2.60; 95% CI: 1.04–6.49) but not UC. Current smokers experienced a reduced risk of UC along with an increased risk of CD. Prior appendectomy was associated with a decreased the risk of UC (OR: 0.37; 95% CI: 0.14–1.00).

Conclusions: Our results support the hypothesis of an increased risk of inflammatory bowel disease associated with oral contraceptives use and suggest a similar effect of hormone replacement therapy on CD. We also confirmed the effects of smoking and appendectomy on inflammatory bowel disease.


L. A. García Rodríguez*, A. González-Pérez*, S. Johansson, M.-A. Wallander

*Centro Español de Investigación Farmacoepidemiológica (CEIFE), Madrid, Spain;

AstraZeneca R&D Mölndal, Sweden;
Section of Preventive Cardiology, Göteborg University, Sweden;
Department of Public Health and Caring Science, Uppsala University, Sweden


Aliment Pharmacol Ther. 2005;22(4):309-315.

©2005 Blackwell Publishing

To read this article in full, please click here:

http://www.medscape.com/viewarticle/510581?src=mp

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