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Irritable Bowel Syndrome in the United States: Prevalence, Symptom Patterns and Impact
      07/05/05 03:40 PM

From Alimentary Pharmacology & Therapeutics

Irritable Bowel Syndrome in the United States: Prevalence, Symptom Patterns and Impact

A. P. S. Hungin; L. Chang; G. R. Locke; E. H. Dennis; V. Barghout

Summary and Introduction
Background: The impact of irritable bowel syndrome, a gastrointestinal motility disorder, is underestimated and poorly quantified, as clinicians may see only a minority of sufferers.
Aim: To determine the prevalence, symptom patterns and impact of irritable bowel syndrome in the US.
Methods: This two-phase community survey used quota sampling and random-digit telephone dialling (screening interview) to identify individuals with medically diagnosed irritable bowel syndrome or individuals not formally diagnosed, but fulfilling irritable bowel syndrome diagnostic criteria (Manning, Rome I or II). Information on irritable bowel syndrome symptoms, general health status, lifestyle and impact of symptoms on individuals' lives was collected using in-depth follow-up interviews. Data were also collected for healthy controls identified in the screening interviews.
Results: The total prevalence of irritable bowel syndrome in 5009 screening interviews was 14.1% (medically diagnosed: 3.3%; undiagnosed, but meeting irritable bowel syndrome criteria: 10.8%). Abdominal pain/discomfort was the most common symptom prompting consultation. Most sufferers (74% medically diagnosed; 63% undiagnosed) reported alternating constipation and diarrhoea. Previously diagnosed gastrointestinal disorders occurred more often in sufferers than non-sufferers. Irritable bowel syndrome sufferers had more days off work (6.4 vs. 3.0) and days in bed, and reduced activities to a greater extent than non-sufferers.
Conclusions: Most (76.6%) irritable bowel syndrome sufferers in the US are undiagnosed. Irritable bowel syndrome has a substantial impact on sufferers' well-being and health, with considerable socioeconomic consequences.

Irritable bowel syndrome (IBS) is a chronic, episodic functional gastrointestinal (GI) disorder characterized by abdominal pain/discomfort and altered bowel habit (constipation, diarrhoea or alternating periods of both).[1] Patients often experience additional symptoms such as bloating, sensation of incomplete evacuation, straining (constipation) and urgency (diarrhoea). IBS patients can experience symptoms for many years, with an average duration of 10 or more years.[1,2] IBS is often unrecognized or untreated, with as few as 25% of IBS sufferers seeking professional health care.[3] Those seeking care are often frustrated by the lack of effectiveness of traditional treatment and management strategies.[4]

IBS prevalence is estimated to be 10-15% in Western countries.[5-9] Prevalence data and information on the health care-seeking behaviour of IBS sufferers have mostly been derived from independent studies using different methodologies and different diagnostic criteria. As there are no IBS-specific biological markers to aid diagnosis, doctors generally rely on symptom-based criteria. At least three sets of diagnostic criteria have been developed, including the Manning,[10] Rome I[11] and Rome II criteria.[12] The Rome I and II criteria are more refined than the Manning criteria, and include symptom duration within their definitions. Variations in study design, particularly the criteria used to diagnose IBS, affect the ability to compare or summarize data from multiple studies.[13]

One challenge of population-based IBS studies is ensuring that IBS is accurately diagnosed using specific, validated criteria, rather than the clinical judgement of health care professionals.[7]

IBS places a significant financial burden on society. Symptoms can significantly impact on the quality of life of sufferers, with considerable socioeconomic consequences.[14-18] For example, absenteeism from work is more prevalent in individuals with IBS than in those without,[1,19] and employers in the United States (US) are estimated to pay, on average, $1251 more for individuals with IBS than matched control beneficiaries over a 1-year period ( P < 0.001).[20]

A recent European study investigated the prevalence, symptom pattern and impact of IBS across eight countries in an attempt to define the magnitude of the problem facing health care providers.[21] The present study, which used the same methodology, evaluated IBS prevalence, symptom pattern and impact on work, social activities and well-being of sufferers in the US. Attitudes towards the health and consultation behaviour of IBS sufferers were also assessed.

Materials and Methods
Survey Methodology
A random-digit dialling technique as described previously[21] was used to identify study participants. This technique has proven feasibility and accuracy in health research[22-24] and enhances the representativeness of the study. Random-digit dialling allowed large numbers of people in the US to be easily identified while avoiding the possibility of cluster sampling often seen with multiple fixed-site surveys. Sampling limitations often noted with postal surveys were also avoided. Research supports this technique as a highly efficient way of yielding accurate data.[22-24]

This methodology assumed that more than 90% of the US households had a telephone and that approximately 25% of numbers were unlisted. Random-digit dialling sampling enabled numbers in the US to be assigned with a probability of selection. As previously described,[21] a random initial sample was drawn from all known listings using a 1 in n sampling interval and an algorithm was then utilized to randomize the last two digits, thus ensuring the inclusion of unlisted numbers. All telephone numbers were prescreened for a valid dialling tone to maximize data efficiency. All fieldwork was conducted on weekday evenings and weekends so that the working population was represented in the study. In order to enhance representativeness, quota sampling was applied in terms of age and gender. This survey was carried out by The Sample Surveys Research Group (now Synovate), West Malling, UK, and commissioned by Novartis Pharmaceuticals, New Jersey, US.

Development and Application of the Questionnaires
The survey included two questionnaires and was executed in two phases; the development of the original questionnaires has been previously described.[21] The first questionnaire was subjected to five stages of piloting and testing, including respondent validation. Further validation was conducted using clinicians and lay individuals in the US - terminology modification ensured respondent comprehension. The revised US version was piloted amongst 'live' respondents prior to commencement of fieldwork. The locally derived and adapted questionnaire was then tested in the US using the telephone interview technique.

In the first phase, a screening questionnaire was employed to identify subjects already diagnosed with IBS (medically diagnosed by their clinician) and to elicit information that identified non-diagnosed IBS sufferers according to the Manning, Rome I or Rome II diagnostic criteria. Subjects were classified as having undiagnosed IBS if they confirmed that they suffered from at least two of the Manning criteria and experienced abdominal pain/discomfort at least once in every 2 months in the previous 12 months. The screening questionnaire was presented to potential participants as being part of a general health project in order to avoid introducing bias and directing responses towards IBS or other GI conditions.

Patients were defined as having IBS with constipation (IBS-C) if they experienced one or more of the following: harder/more lumpy stools than usual, the need to pass stools less often than usual (<3 times/week), or periods of straining, which was not accompanied by the need to pass stools more often than usual (>3 times/day), looser/more watery stools than usual and periods of urgency. Patients were defined as having IBS with diarrhoea (IBS-D) if they experienced one or more of the following: looser/more watery stools than usual, the need to pass stools more often than usual (>3 times/day), or periods of urgency, which were not accompanied by the need to pass stools less often than usual (<3 times/week), harder/more lumpy stools than usual and periods of straining. Patients with other bowel habit patterns were defined as having alternating IBS (IBS-A). Differentiation into these specific IBS subtypes was based only on the symptoms suffered by each respondent, without reference to a specific time frame.

In the second phase of the survey, respondents who were identified as having IBS in phase I of the survey, either medically diagnosed or diagnosed using IBS criteria (Manning, Rome I or Rome II), were invited to participate in a more formal interview regarding their symptoms, general health factors, lifestyle and impact of IBS symptoms on their lives. Data on comorbid conditions, therapy/medication use and consultation patterns were also collected. Thus, three groups of respondents were identified: those with medically diagnosed IBS; those who had IBS that had not been medically diagnosed, but who fulfilled IBS diagnostic criteria; and a healthy comparator group identified from the screening questionnaire as not having IBS. Any individuals who had experienced IBS symptoms within the previous 12-month period were identified as current IBS sufferers.

For symptoms of constipation or diarrhoea, individuals were questioned (based onthe IBS diagnostic criteria) about: any periods needing to pass stools more often than usual (>3 times/day) or less often than usual (<3 times/week); any periods when stools were looser/more watery than usual or harder/more lumpy than usual; periods of straining when going to pass a stool; periods of urgency when going to pass a stool; feeling of incomplete evacuation after passing a stool; periods of bloating.

As in the European study,[21] the development of the questionnaire used in the US population incorporated the clinical experience of the clinicians involved with this study. Alternative diagnoses (not IBS) were excluded at an early stage of the questionnaire and pilot research was performed to ensure the Manning and Rome I/II criteria were effective in this setting. The questionnaire was designed and carefully validated to avoid order effects, such as suggestion based on earlier questions.

Based on the assumption of a conservative IBS prevalence rate of 5-10%, it was estimated that 5000 respondents would need to be contacted to reach 250-500 IBS sufferers in the US. Specific target age groups for the population were 18-34, 35-54 and over 55 years, with equal numbers contacted within these age groups.

The study was carried out in the US in a sample of subjects aged 18 years or over. Those previously diagnosed with Crohn's disease, ulcerative colitis, coeliac disease, diverticulitis, peptic ulcer or cancer (including colon and gynaecological cancers) were excluded from the results because of possible overlap with IBS symptoms.

From approximately 14 000 initial telephone contacts, a total of 5009 screening interviews were conducted; all questions in this section were related to general health. Among these, 708 individuals were identified as having current IBS (any diagnostic criteria) and, from this group, 318 individuals participated in the second phase of the questionnaire (366 individuals either did not want to take part in the second phase of the questionnaire or did agree but were not available when contacted).

Prevalence, Characteristics and Symptom Patterns of IBS (Medically Diagnosed and Not Medically Diagnosed)
Overall 708 individuals (14.1% of total screened) were identified as having current IBS [medically diagnosed ( n = 166; 3.3%) or met any diagnostic criteria (not medically diagnosed; n = 542; 10.8%)]. Results from this questionnaire are shown in Table 1 .

In general, medically diagnosed IBS patients reported a greater prevalence of individual IBS symptoms. The Manning criteria identified all current IBS sufferers (100%); the Rome I criteria identified 73% and the Rome II criteria identified 62%. Thus, only partial overlap of the IBS diagnosis was seen across these diagnostic criteria. The Rome II criteria appeared to be the most restrictive set. Of those individuals who had been medically diagnosed with IBS, 4% were deemed to have IBS-C compared with 21% with IBS-D. In those not medically diagnosed, these percentages were 15% and 21%, respectively. Most individuals with IBS (74% of those medically diagnosed and 63% not medically diagnosed) reported alternating symptoms of constipation and diarrhoea (IBS-A). When IBS sufferers were asked to categorize themselves according to these three subgroups, only approximately one-third of individuals medically diagnosed and not medically diagnosed with IBS defined themselves as having IBS-A (33% and 27%, respectively) compared with IBS-C (17% and 30%, respectively) and IBS-D (45% and 29%, respectively).

Age/Sex Distribution of Current IBS Sufferers (Medically Diagnosed and Not Medically Diagnosed)
Overall, the peak ages for current IBS symptoms were between 25 and 54 years (67.3% of IBS total; Table 1 ). IBS was more common in women than men (64% vs. 36%, respectively), particularly among those who had been medically diagnosed with IBS (81.3% vs. 18.7%, respectively). The highest prevalence of IBS was seen in working women, with a prevalence of 21% (5% medically diagnosed, 16% not medically diagnosed).

Comorbid Conditions
Current IBS sufferers (both medically diagnosed and not medically diagnosed) were more likely to have suffered from other GI disorders of function (previously diagnosed by a doctor) compared with non-IBS sufferers. IBS sufferers were twice as likely to suffer from gastro-oesophageal reflux disease (GERD; 22% vs. 10%, P < 0.001) compared with non-IBS sufferers.

Duration and Patterns of Symptoms
Results of the second phase of this study confirmed that IBS is a chronic disorder, with 16% of current IBS sufferers being medically diagnosed with the condition in the previous 12-month period, 8% in the previous 13-24 months, 26% in the previous 2-5 years and 14% 6-10 years ago. Overall, one-third of current IBS sufferers had had IBS for more than 10 years.

Although respondents had IBS for considerable periods of time, IBS symptoms remained fairly constant over time with 73% of medically diagnosed IBS sufferers reporting that their symptoms had never changed. Only 22% of current IBS sufferers reported some degree of symptom improvement since the screening interview. Current IBS sufferers typically experienced symptoms for an average of 8.1 days/month and reported a wide range of symptoms, with abdominal pain/discomfort being the most commonly reported (90%; Figure 1). The majority (71%) described their overall IBS symptoms as fairly or very painful. On each day with current symptoms (designated as a 'suffering day'), respondents with IBS had an average of 2.4 episodes of IBS. These episodes varied in duration but more than half (52%) of current sufferers experienced episodes more than 60 min in duration. More than half (64%) of individuals with current IBS symptoms believed that an episode of IBS was triggered by a certain food or drink while 30% cited stress as the trigger.

There appeared to be a gender difference in the reporting of IBS-related symptoms in current IBS sufferers. Women were more likely to report constipation, bloating, trapped wind, swollen tummy, tightness of clothing and tiredness. There were no differences in prevalence of abdominal pain, diarrhoea and heartburn between men and women with IBS.

Impact of IBS on Work, Lifestyle and Health
Responses from current IBS sufferers (medically diagnosed and not medically diagnosed) indicate that IBS negatively impacted upon a wide range of daily activities. Work productivity, particularly the ability to concentrate, and time management, was significantly affected in respondents with IBS compared with individuals without IBS (Figure 2; P = 0.01). The proportion of men and women reporting an impact was not significantly different.

In the 12 months prior to the survey, IBS sufferers had more time off work, spent more days in bed and cut down on usual activities on more days compared with non-IBS sufferers. Nearly one-quarter of IBS respondents worked fewer hours, 11% missed work and 67% felt less productive when at work because of their symptoms. Two-thirds of current IBS sufferers had cut back on the number of overall activities during the previous 12-month period for an average of 15 days. The average number of days affected by ill health leading to absenteeism was 6.4 vs. 3.0 days (current IBS sufferers vs. non-IBS sufferers). Overall, current IBS sufferers were twice as likely to spend at least 1 day in bed or cut back on usual activities compared with non-IBS sufferers. Nearly one-quarter of current IBS sufferers had missed social engagements.

IBS symptoms also had a significant impact on social well-being and daily social activities among sufferers compared with non-sufferers ( P = 0.01). Undertaking long journeys, going out for a meal and going on holiday were all noted as more of a problem for IBS sufferers than controls (Figure 3a; P = 0.01). In addition, diet and food choice were also adversely affected by current IBS symptoms (Figure 3b; P = 0.01 vs. individuals without IBS). IBS sufferers reported a wide range of effects of symptoms on daily life (>/=5 points on a scale of 0 = no impact to 10 = significant impact), in particular many felt they had to be either near a toilet or make frequent trips to the toilet (Figure 4). Again, the proportion of men and women reporting an impact was not significantly different.

Current IBS sufferers were more likely to perceive themselves as having poor health; compared with 54% of non-IBS sufferers, only 35% of IBS sufferers described themselves as having good health. More than half (57%) of all current IBS sufferers questioned felt that they would have more control over their life without IBS symptoms. An impact of health on relationships was also more evident amongst current IBS sufferers compared with non-IBS sufferers: more IBS sufferers found it difficult to make new friends (46% vs. 40%, P < 0.001) and have physical relationships (52% vs. 41%, P < 0.001), and they felt that their IBS symptoms affected family relationships (48% vs. 40%, P < 0.001).

Attitudes to Condition

In general, the attitude towards health and overall quality of life appeared to be affected to a greater extent in medically diagnosed patients than in IBS sufferers who were not medically diagnosed ( Table 2 ).

Current IBS sufferers commonly informed their partner about their condition (68%). Although they also often told other family members (56%) and friends (54%), they were less likely to inform colleagues (22%) or their employer (16%). Most confidants were deemed to be very (44%) or fairly (39%) understanding. Overall, one-quarter of IBS sufferers highlighted that their self-confidence was reduced as a result of IBS; this was particularly evident among the medically diagnosed group (46% vs. 17% of those not medically diagnosed). The majority (87%) of respondents medically diagnosed with IBS believed their IBS to be a real medical condition, compared with only 43% of individuals not medically diagnosed ( Table 2 ). As an indication of desire for effective therapy, nearly half of current IBS sufferers (46%) agreed that they would try 'anything' to alleviate their IBS symptoms.

Consultation Pattern and Health Care Use
A primary care doctor was the most common health professional seen by current IBS sufferers (83%); gastroenterologists were the next most commonly consulted group (40%; Table 2 ). Abdominal pain/discomfort was the most common reason for consulting a health professional (28% of consultations), followed by symptom frequency (10%). Current IBS sufferers had seen a doctor or nurse an average of 4.2 times in the past 12 months if medically diagnosed or 1.3 times if not medically diagnosed. More than half (53%) of respondents not medically diagnosed had seen a health professional at some time for their condition. In patients medically diagnosed with IBS, 25% had visited a health professional five or more times before their IBS diagnosis.

Medication Used
More than half (58%) of the current IBS sufferers who had visited their health professional had been prescribed medication and a similar number (57%) received dietary and lifestyle advice ( Table 2 ). The main medications taken were antacid and acid suppression therapy (25%), antidiarrhoeals (22%) and laxatives (11%); the serotonergic agents, tegaserod and alosetron, were not available at the time of the study. Antidepressant/anti-anxiety medication was taken by 1% of participants (5% in the medically diagnosed group and 0% in those not medically diagnosed). Most IBS sufferers regularly used over-the-counter medication (60%) and 47% had altered their diet in an attempt to alleviate their IBS symptoms. Treatments were deemed ineffective for a number of symptoms including constipation (41%), bloating (34%) and trapped wind (31%). Treatments for abdominal pain/discomfort were considered to be fairly effective in 53% of sufferers, although 18% considered them to be not at all effective.

This study confirms the high prevalence of IBS in the US population and its impact on the working life, social activities and well-being of sufferers. The overall prevalence of IBS in this population was 14.1%, with only 3.3% being medically diagnosed. This compares with a prevalence rate of 11.5% in a previous European study,[21] and is consistent with other large US-based epidemiological studies, where prevalence estimates cluster around 10-15%.[25,26] Expected variations in diagnostic rates according to Manning, Rome I and Rome II criteria were seen, as previously noted.[21,27,28] Clearly, IBS prevalence can vary substantially depending on the diagnostic criteria employed.[29] This comprehensive, representative survey used specific, validated IBS diagnostic criteria to estimate prevalence and symptom patterns, and also assessed impact of IBS on work, lifestyle and health. In this study, prevalence rates were highest among those aged 25-54 years, and the prevalence of IBS among women was approximately two times higher than that recorded for men in individuals medically or not medically diagnosed with IBS. These findings corroborate previously published reports, which demonstrated a higher IBS prevalence in women than in men.[30,31] In patients medically diagnosed with IBS, 25% had visited a health professional at least five times before being formally diagnosed, suggesting that diagnostic criteria are not being properly utilized, IBS symptoms are not always recognized or are misdiagnosed, and/or that the diagnosis of IBS is not being communicated to the patient.

This US population study adopted a survey methodology similar to that used in a recent European study of IBS prevalence and impact.[21] That study comprised approximately 5000 respondents from each of eight countries with a total sample population of 41 984, whereas in the US, the total sample population was 5000. Thus, comparisons between the two studies remain limited. The only other US study using random-digit dialling to assess IBS included 1014 adult women with IBS.[28,32]

The clinical presentation of IBS is quite varied,[33] with sufferers in the present study reporting a wide range of symptoms. IBS sufferers also reported that their symptoms rarely improve and were fairly or very painful, as highlighted in previous studies.[2,34] In this study, the prevalence of individual IBS symptoms was higher in medically diagnosed IBS patients than in current IBS sufferers who were not medically diagnosed. This finding may be related to IBS severity, which is likely to be greater in patients presenting for treatment. Medically diagnosed patients may also have a greater awareness of IBS and its associated symptoms. Data confirmed that IBS is a long-term condition, with one-third of IBS sufferers having experienced IBS symptoms for over 10 years, a figure comparable with that in Europe (40%).[21]

It is well documented that IBS can have a considerable impact on sufferers' lives,[16,21,26,35-37] and this is compounded by the condition's chronic and episodic nature. This study reinforces that IBS has a substantial impact on quality of life. There was a large impact on absenteeism and work productivity, confirming previous findings in both US[1,2,20,34] and European[21] populations. Additionally, ill health was recorded for an average of 6.4 days in current IBS sufferers, compared with 3.0 days in non-IBS sufferers. One in six current IBS sufferers in the US had changed their work schedule and one in four had worked fewer hours. These data support findings from Drossman et al., [26] who reported that IBS patients missed three times more days from work than non-sufferers. Time management, the ability to concentrate and commuting time were also negatively affected in IBS sufferers in the present study. Regular social activities such as going out for a meal, long journeys or holidays were also hindered. Thus, the symptoms of IBS appear to affect the ability to live a normal life. This is further compounded by the fact that other functional GI disorders often coexist with IBS.[38] Although this was not fully assessed in this study, 24% of IBS sufferers had also suffered from GERD or dyspepsia.

Substantial health care use because of IBS was recorded in this US population. Sufferers used a wide range of medications for relief of IBS symptoms. Medically diagnosed IBS patients with current symptoms appeared to take fewer antisecretory medications and laxatives than those not medically diagnosed, presumably due to the availability of these medications over the counter. This finding contradicts data from Shih et al., [39] who reported that 89% of doctor visits generated prescriptions. At the time of the present study, treatment options for abdominal pain/discomfort, bloating and constipation were only viewed as being completely effective in a small proportion of users. As IBS symptoms are intermittent, treatment was often restricted to times when patients experienced symptoms.

A varying perception of IBS-A was highlighted in this study. Most IBS sufferers (74% medically diagnosed, 63% not medically diagnosed) had alternating symptoms of constipation and diarrhoea as defined by doctors and diagnostic criteria. However, when sufferers were asked to categorize themselves, only approximately one-third of medically and not medically diagnosed respondents with IBS defined themselves as having IBS-A (33% and 27%, respectively) compared with IBS-C (17% and 30%, respectively) and IBS-D (45% and 29%, respectively). This finding is in contrast to other published data, which reported equal prevalence rates of IBS-C, IBS-D and IBS-A.[25,34] A possible explanation for this discrepancy is the use of more strict criteria for IBS-A in the current study than in the Rome II subclassification.

In conclusion, IBS is a prevalent disorder that significantly impacts work, lifestyle and social well-being. Diagnosing and managing IBS can be challenging due to the lack of a diagnostic marker and effective treatment options. Individuals with IBS who are not formally diagnosed reported a significant prevalence of GI symptoms, which impacted on their work and other daily activities, although in some instances to a lesser degree than medically diagnosed individuals. All IBS sufferers face the challenge of their condition on a daily basis and this study highlights the huge unmet therapeutic need in IBS.

Aliment Pharmacol Ther. 2005; 21 (11): 1365-1375. ©2005 Blackwell Publishing

A. P. S. Hungin ,* L. Chang ,† G. R. Locke ,‡ E. H. Dennis ,§ V. Barghout §

*Centre for Integrated Health Care Research, Wolfson Research Institute, University of Durham, Stockton-on-Tees, UK

†UCLA, Los Angeles, CA

‡Mayo Clinic College of Medicine, Rochester, NY

§Novartis Pharmaceuticals Corp., East Hanover, NJ

Aliment Pharmacol Ther. 2005; 21 (11): 1365-1375. ©2005 Blackwell Publishing

Heather is the Administrator of the IBS Message Boards. She’s the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

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. * Subtypes of Irritable Bowel Syndrome Based on Abdominal Pain/Discomfort Severity and Bowel Pattern HeatherAdministrator   02/10/11 10:14 AM
. * Irritable Bowel Syndrome Is Not In Your Head HeatherAdministrator   09/24/10 02:42 PM
. * Pain perception during colonoscopy higher in IBS patients than in non-IBS patients HeatherAdministrator   07/21/10 03:52 PM
. * Can Choir Singing Improve Irritable Bowel Syndrome? HeatherAdministrator   06/24/10 01:48 PM
. * Patients with IBS are NOT more likely to develop polyps, colon cancer HeatherAdministrator   05/12/10 01:18 PM
. * Rome Foundation Introduces Clinical Tool For Diagnosis Of Functional Gastrointestinal Disorders HeatherAdministrator   04/12/10 11:40 AM
. * Rotating Shift Workers At More Risk For Irritable Bowel Syndrome HeatherAdministrator   04/12/10 11:39 AM
. * Irritable bowel syndrome (IBS) does seem to run in families HeatherAdministrator   04/02/10 11:14 AM
. * IBS Does Not Increase Risk of Colon Cancer or IBD HeatherAdministrator   03/12/10 11:30 AM
. * Validation of Symptom-Based Diagnostic Criteria for Irritable Bowel Syndrome HeatherAdministrator   03/11/10 01:53 PM
. * Importance of early diagnosis in patients with irritable bowel syndrome HeatherAdministrator   03/11/10 01:44 PM
. * Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome HeatherAdministrator   03/11/10 01:12 PM
. * Constipation: a potential cause of pelvic floor damage? HeatherAdministrator   09/29/09 12:10 PM
. * Patients say they would give up 25% of their remaining life to be rid of IBS HeatherAdministrator   08/28/09 01:21 PM
. * IBS - it's the pain and the stigma HeatherAdministrator   08/28/09 01:16 PM
. * Wasington state retailers required to make bathrooms available to people with IBS and IBD HeatherAdministrator   05/13/09 01:06 PM
. * Development of an educational intervention for patients with Irritable Bowel Syndrome HeatherAdministrator   02/06/09 12:20 PM
. * Prevalence of Functional Gastrointestinal Disorders in Patients With Fibromyalgia and the Role of Psychologic Distress HeatherAdministrator   01/22/09 04:47 PM
. * Highlights of ACG's New Recommendations on IBS Therapies HeatherAdministrator   01/09/09 11:10 AM
. * Irritable Bowel Syndrome Can Have Genetic Causes HeatherAdministrator   12/16/08 11:42 AM
. * Is IBS part of a cascade of events? HeatherAdministrator   10/27/08 10:56 AM
. * Contributions of Pain Sensitivity and Colonic Motility to IBS Symptom Severity HeatherAdministrator   10/21/08 02:38 PM
. * Subgroup classification in irritable bowel syndrome patients over time HeatherAdministrator   10/09/08 01:56 PM
. * Genetic factors may play a role in IBS HeatherAdministrator   09/26/08 02:52 PM
. * Genetics of Irritable Bowel Syndrome HeatherAdministrator   08/27/08 12:43 PM
. * Irritable bowel syndrome: an international study of symptoms in eight countries HeatherAdministrator   08/07/08 12:42 PM
. * Gallstones, cholecystectomy and irritable bowel syndrome HeatherAdministrator   04/22/08 04:01 PM
. * Abdominal Bloating in Employed Adults: Prevalence, Risk Factors, and Association With Other Bowel Disorders HeatherAdministrator   04/22/08 02:07 PM
. * IBS is keeping me hostage! HeatherAdministrator   03/14/08 11:12 AM
. * Abdominal Bloating and Distension in Functional Gastrointestinal Disorders HeatherAdministrator   02/28/08 03:16 PM
. * Psychological distress and GI symptoms are related to severity of bloating HeatherAdministrator   02/28/08 02:40 PM
. * Irritable Bowel Syndrome's Possible Genetic Link HeatherAdministrator   02/04/08 10:43 AM
. * Patients with allergies appear to have a higher incidence of irritable bowel syndrome (IBS) HeatherAdministrator   02/04/08 10:19 AM
. * Train operator suffering from irritable bowel syndrome sues for lost wages HeatherAdministrator   12/06/07 02:45 PM
. * IBS may not affect small bowel transit time, but age does HeatherAdministrator   10/24/07 01:56 PM
. * Diagnostic work-up of IBS HeatherAdministrator   10/24/07 12:15 PM
. * Neural mechanisms of pelvic organ cross-sensitization. HeatherAdministrator   10/10/07 11:41 AM
. * Incidence and Prognosis of Post-Infectious Irritable Bowel Syndrome HeatherAdministrator   09/13/07 11:21 AM
. * Irritable bowel syndrome and the Rome III criteria: for better or for worse? HeatherAdministrator   08/28/07 04:15 PM
. * Quality of Life in Patients With IBD and IBS Differs Between Subjects Recruited from Clinic or the Internet HeatherAdministrator   08/09/07 11:31 AM
. * Fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects HeatherAdministrator   08/02/07 03:08 PM
. * Irritable bowel syndrome and bloating HeatherAdministrator   08/02/07 03:02 PM
. * IBS And Restless Legs Syndrome Linked HeatherAdministrator   08/02/07 02:50 PM
. * Overlapping upper and lower gastrointestinal symptoms in irritable bowel syndrome patients HeatherAdministrator   06/20/07 01:49 PM
. * Bacterial Overgrowth Apparently NOT Important in IBS HeatherAdministrator   06/06/07 10:51 AM
. * Irritable bowel syndrome: patients' attitudes, concerns and level of knowledge HeatherAdministrator   05/23/07 02:32 PM
. * Influence of genetics on irritable bowel syndrome HeatherAdministrator   05/23/07 02:25 PM
. * Diarrhea-predominant irritable bowel syndrome and possible microscopic colitis HeatherAdministrator   05/11/07 03:37 PM
. * Breath Methane Levels Correlate With Constipation in IBS HeatherAdministrator   04/28/07 10:13 AM
. * 7 common myths – and facts – about IBS HeatherAdministrator   04/11/07 04:17 PM
. * Symptomatic overlap between irritable bowel syndrome and microscopic colitis HeatherAdministrator   03/18/07 04:48 PM
. * Reactions to a guided self-management intervention in a randomised controlled trial for IBS HeatherAdministrator   03/18/07 04:39 PM
. * Audit of Subtypes of Functional Constipation in a Gastroenterology Referral Center HeatherAdministrator   03/18/07 04:26 PM
. * New insights into the pathogenesis and pathophysiology of irritable bowel syndrome HeatherAdministrator   03/01/07 01:17 PM
. * Overly Anxious and Driven People Prone to Irritable Bowel Syndrome HeatherAdministrator   03/01/07 12:37 PM
. * Paid Participants Sought for Online IBS University Research Study HeatherAdministrator   02/26/07 11:43 AM
. * Physical activity and intestinal gas clearance in patients with bloating. HeatherAdministrator   02/04/07 04:11 PM
. * Familial Aggregation in Constipated Subjects HeatherAdministrator   01/21/07 04:12 PM
. * Participate in a research study looking at attitudes and opinions about people who have IBS HeatherAdministrator   12/29/06 04:15 PM
. * Most important barriers to the optimal management of patients with IBS-C and chronic constipation HeatherAdministrator   12/01/06 01:23 PM
. * Traveler's Diarrhea May Boost Risk of Irritable Bowel Syndrome HeatherAdministrator   10/14/06 02:28 PM
. * Irritable Bowel Syndrome Linked to Migraine, Fibromyalgia, and Depression HeatherAdministrator   10/14/06 02:24 PM
. * Restricted Fetal Growth Linked to Irritable Bowel Syndrome HeatherAdministrator   10/14/06 02:21 PM
. * The Science of IBS - Postinfectious IBS and Small Intestinal Bacterial Overgrowth HeatherAdministrator   09/30/06 03:23 PM
. * The Science of IBS - Environment and Genetics HeatherAdministrator   09/17/06 02:36 PM
. * Making a Positive Diagnosis of IBS HeatherAdministrator   08/19/06 11:56 AM
. * IBS -- Review and What's New - Abstract and Introduction HeatherAdministrator   08/05/06 03:58 PM
. * Treatment of Functional Diarrhea HeatherAdministrator   07/17/06 01:54 PM
. * Prevalence and Incidence of Chronic Constipation HeatherAdministrator   07/05/06 05:35 PM
. * Rome III Diagnostic Criteria HeatherAdministrator   06/12/06 04:16 PM
. * Determinants of Healthcare-Seeking Behaviour in IBS HeatherAdministrator   06/04/06 11:48 AM
. * Genetic cause for irritable bowel syndrome HeatherAdministrator   05/29/06 01:48 PM
. * Cytokines May Provide Marker for Irritable Bowel Syndrome HeatherAdministrator   05/14/06 05:04 PM
. * Introduction to IBS Constipation - the Problem HeatherAdministrator   05/14/06 04:57 PM
. * Gender, Age, Society, Culture, and the Patient's Perspective in IBS HeatherAdministrator   05/13/06 03:16 PM
. * What IBS Patients Need - But Don't Get - From Their Physicians HeatherAdministrator   05/08/06 04:37 PM
. * Antibiotic use and irritable bowel syndrome (IBS). HeatherAdministrator   04/15/06 04:02 PM
. * Older Versus Younger Patients with Irritable Bowel Syndrome HeatherAdministrator   04/15/06 03:11 PM
. * Prevalence of irritable bowel syndrome and depression in fibromyalgia HeatherAdministrator   04/15/06 03:04 PM
. * Intestinal serotonin signalling in irritable bowel syndrome HeatherAdministrator   04/15/06 02:59 PM
. * Gender-related differences in visceral perception in health and irritable bowel syndrome HeatherAdministrator   04/15/06 02:47 PM
. * Role of Stress, Infection, Inflammation in IBS HeatherAdministrator   03/16/06 12:22 PM
. * Pathophysiologic Mechanisms of IBS HeatherAdministrator   03/16/06 12:16 PM
. * Gum Chewing Stimulates Bowel Activity and Reduces Surgical Recovery Time HeatherAdministrator   03/04/06 01:04 PM
. * A bulging midriff roughly doubles women's chances of gallstone surgery HeatherAdministrator   03/04/06 12:56 PM
. * Lifestyle Factors and Symptoms of Gastro-oesophageal Reflux HeatherAdministrator   02/18/06 01:42 PM
. * IBS Patients Show Greater Brain Response to Subliminal Gut Stimuli HeatherAdministrator   02/18/06 01:32 PM
. * Discrepancies between Patient-Reported Outcomes and Clinician-Reported Outcomes in IBS HeatherAdministrator   02/01/06 12:15 PM
. * Distension technique influences the relationship between colonic and rectal hypersensitivity in IBS HeatherAdministrator   02/01/06 12:04 PM
. * Stability of Irritable Bowel Syndrome Using a Rome II-Based Classification HeatherAdministrator   01/18/06 04:27 PM
. * Digestive Woes May Keep the Overweight From Exercising HeatherAdministrator   01/18/06 04:00 PM
. * Possible role of nitric oxide in visceral hypersensitivity in patients with irritable bowel syndrome HeatherAdministrator   01/08/06 05:03 PM
. * A Survey on Patient Educational Needs in Irritable Bowel Syndrome HeatherAdministrator   01/08/06 04:53 PM
. * Gut motor function: immunological control in enteric infection and inflammation HeatherAdministrator   12/21/05 12:41 PM
. * Post-infectious Irritable Bowel Syndrome HeatherAdministrator   12/19/05 04:55 PM
. * Clinical Insights in IBS-C and Chronic Constipation HeatherAdministrator   12/08/05 12:37 PM
. * New Studies Gauge Knowledge, Attitudes and Preferences of Patients with Irritable Bowel Syndrome HeatherAdministrator   11/12/05 01:30 PM
. * The Genetics of Irritable Bowel Syndrome HeatherAdministrator   11/12/05 01:10 PM
. * Irritable Bowel Syndrome Study Shows That Targeted Antibiotics Lead To Long-lasting Improvement HeatherAdministrator   11/12/05 01:00 PM
. * Colonic Immune Activity and Blood T Lymphocytes in Patients With Irritable Bowel Syndrome HeatherAdministrator   10/28/05 11:48 AM
. * Brain activation responses to auditory stimuli in IBS HeatherAdministrator   10/28/05 11:42 AM
. * Functional Constipation Linked to Obesity in Children HeatherAdministrator   10/11/05 01:43 PM
. * Childhood Abdominal Pain May Progress to Adult Irritable Bowel Syndrome HeatherAdministrator   10/11/05 01:36 PM
. * Bronchial Hyperresponsiveness in Irritable Bowel Syndrome HeatherAdministrator   10/11/05 01:16 PM
. * The Impact of Somatization on the Use of Gastrointestinal Health-Care Resources in Patients with IBS HeatherAdministrator   09/22/05 04:51 PM
. * Abdominal Bloating - Four Factors HeatherAdministrator   09/22/05 04:47 PM
. * Abdominal Bloating HeatherAdministrator   09/22/05 04:46 PM
. * Guidelines for the Management of Dyspepsia HeatherAdministrator   09/22/05 04:35 PM
. * IBS and Functional Dyspepsia: Different Diseases or a Single Disorder With Different Manifestations? HeatherAdministrator   09/13/05 01:03 PM
. * Increased Prevalence of Obesity in Children With Functional Constipation HeatherAdministrator   09/13/05 12:45 PM
. * Irritable Bowel Syndrome: Toward an Understanding of Severity HeatherAdministrator   09/01/05 11:19 AM
. * How Do Symptoms in Chronic Constipation and IBS With Constipation Differ? HeatherAdministrator   08/22/05 04:51 PM
. * Role of Carbon Dioxide-Releasing Suppositories in the Treatment of Chronic Functional Constipation HeatherAdministrator   08/22/05 04:32 PM
. * Physiological Mechanisms Underlying Perceptions of Nausea and Stomach Fullness HeatherAdministrator   08/07/05 04:33 PM
. * Gastrointestinal infections can have lasting consequences as IBS HeatherAdministrator   08/07/05 04:08 PM
. * Dyspepsia and Irritable Bowel Syndrome After a Salmonella Gastroenteritis Outbreak HeatherAdministrator   07/24/05 02:48 PM
. * Abdominal Radiography Not Useful in Constipated Children HeatherAdministrator   07/24/05 02:30 PM
. * IBS—The Irritation of Inflammation HeatherAdministrator   07/24/05 02:16 PM
. * Irritable Bowel Syndrome in the United States: Prevalence, Symptom Patterns and Impact HeatherAdministrator   07/05/05 03:40 PM
. * IBS: Improving Diagnosis, Serotonin Signaling, and Implications for Treatment HeatherAdministrator   07/05/05 03:30 PM
. * Neural Cross-Talk May Explain Overlap of Irritable Bowel, Interstitial Cystitis HeatherAdministrator   07/05/05 03:11 PM
. * Health Economics of IBS HeatherAdministrator   07/05/05 03:01 PM
. * Overlapping Upper and Lower Gastrointestinal Symptoms in Irritable Bowel Syndrome HeatherAdministrator   06/20/05 03:52 PM
. * Diagnostic Yield of Alarm Features in Irritable Bowel Syndrome HeatherAdministrator   06/20/05 03:44 PM
. * Colon Cancer Test Misses Growths in Women HeatherAdministrator   06/05/05 05:56 PM
. * Nongastrointestinal symptoms of irritable bowel syndrome HeatherAdministrator   05/22/05 07:14 PM
. * Partnering With Gastroenterologists to Evaluate Patients With Chronic Constipation HeatherAdministrator   05/08/05 06:16 PM
. * Impairment in Work Productivity and Health-related Quality of Life in Patients With IBS HeatherAdministrator   05/08/05 06:11 PM
. * Nerves, Reflexes, and the Enteric Nervous System: Pathogenesis of the Irritable Bowel Syndrome HeatherAdministrator   05/08/05 06:06 PM
. * What Does the Future Hold for Irritable Bowel Syndrome HeatherAdministrator   05/08/05 06:02 PM
. * Towards a better understanding of abdominal bloating and distension in functional GI disorders HeatherAdministrator   04/24/05 03:40 PM
. * IBS is a risk factor for GERD HeatherAdministrator   04/10/05 06:25 PM
. * New Recommendations for Treating Children With Chronic Abdominal Pain HeatherAdministrator   03/28/05 01:59 PM
. * Irritable bowel syndrome in developing countries HeatherAdministrator   03/28/05 01:29 PM
. * Stress and the gastrointestinal tract HeatherAdministrator   03/28/05 01:27 PM
. * Alternating Bowel Habit Subtype in Patients with Irritable Bowel Syndrome HeatherAdministrator   03/28/05 12:28 PM
. * Fecal Microbiota of Irritable Bowel Syndrome Patients HeatherAdministrator   03/04/05 12:11 PM
. * Post-infectious IBS in patients with Shigella infection HeatherAdministrator   03/04/05 12:03 PM
. * Surgical Treatment of Chronic Functional Constipation? HeatherAdministrator   03/04/05 11:24 AM
. * Chronic constipation in children HeatherAdministrator   02/19/05 05:53 PM
. * Intestinal infection and irritable bowel syndrome. HeatherAdministrator   02/19/05 05:36 PM
. * Overlap of GI symptom complexes in a US community HeatherAdministrator   02/06/05 02:35 PM
. * Magnetic pill tracking: a novel non-invasive tool for investigation of human digestive motility HeatherAdministrator   02/06/05 02:27 PM
. * The value of a general therapeutic approach in subjects with irritable bowel syndrome HeatherAdministrator   02/06/05 02:22 PM
. * Is Constipation Associated with Decreased Physical Activity in Normally Active Subjects? HeatherAdministrator   02/06/05 02:18 PM
. * High interdigestive and postprandial motilin levels in patients with the irritable bowel syndrome HeatherAdministrator   02/06/05 02:12 PM
. * 10% to 20% of older adults have IBS HeatherAdministrator   01/23/05 05:05 PM
. * Diagnostic Criteria for Irritable Bowel Syndrome - Family Practice Doctors Unaware of Guidelines HeatherAdministrator   01/07/05 06:20 PM
. * Stress Increases Visceral Sensitivity in IBS Patients HeatherAdministrator   01/07/05 06:13 PM
. * Treatment of irritable bowel syndrome with colonic pacing HeatherAdministrator   01/07/05 05:53 PM
. * Irritable bowel syndrome: colonoscopy painful and difficult? HeatherAdministrator   01/07/05 05:50 PM
. * Suicide in IBS patients emphasizes need for improvements in treatment HeatherAdministrator   01/07/05 05:47 PM
. * New Risk for Asthma, Allergy Found in the Gut HeatherAdministrator   01/07/05 04:53 PM
. * Salt intake and smoking play major roles in GERD HeatherAdministrator   12/20/04 02:11 PM
. * Constipation and Laxative Use Found to Increase Colon Cancer Risk HeatherAdministrator   12/20/04 01:30 PM
. * Link Between Irritable Bowel Syndrome (IBS), Alcoholism and Mental Illness HeatherAdministrator   12/20/04 01:24 PM
. * Complementary and alternative medicine in gastroenterology HeatherAdministrator   12/20/04 01:16 PM
. * Advances in the Treatment of Chronic Constipation HeatherAdministrator   11/28/04 02:55 PM
. * Symptom patterns in functional dyspepsia and irritable bowel syndrome HeatherAdministrator   11/28/04 02:34 PM
. * Obese Women Face Higher Risk of Colorectal Cancer HeatherAdministrator   11/08/04 04:48 PM
. * Obesity is Associated With Increased Risk of Gastrointestinal Symptoms HeatherAdministrator   10/24/04 07:42 PM
. * Stress Therapy Can Help Irritable Bowel HeatherAdministrator   10/24/04 07:38 PM
. * Relationship Between Colon Ischemia, Irritable Bowel Syndrome HeatherAdministrator   10/11/04 04:15 PM
. * Clinical Update on the Treatment of Constipation in Adults HeatherAdministrator   10/11/04 03:34 PM
. * Racial Differences in the Impact of Irritable Bowel Syndrome on Health-Related Quality of Life HeatherAdministrator   10/11/04 03:25 PM
. * What Differentiates Chronic Constipation From IBS With Constipation? HeatherAdministrator   09/26/04 03:25 PM
. * Treatment options in irritable bowel syndrome HeatherAdministrator   09/26/04 02:57 PM
. * Diagnostic approach to suspected irritable bowel syndrome HeatherAdministrator   09/12/04 03:38 PM
. * Dyssynergic Defecation: Demographics, Symptoms, Stool Patterns, and Quality of Life HeatherAdministrator   09/12/04 03:35 PM
. * Small Intestinal Bacterial Overgrowth - A Framework for Understanding IBS HeatherAdministrator   08/30/04 01:46 PM
. * New views - and some respect - for IBS HeatherAdministrator   08/30/04 01:25 PM
. * Categorization of dysmotility in patients with chronic constipation HeatherAdministrator   08/08/04 02:54 PM
. * Prevalence of IBS according to different diagnostic criteria HeatherAdministrator   08/08/04 02:50 PM
. * Irritable Bowel Can Follow Dysentery HeatherAdministrator   08/08/04 02:37 PM
. * Irritable Bowel Syndrome Remains a Difficult Condition to Manage HeatherAdministrator   07/24/04 02:09 PM
. * Intolerance to visceral distension in functional dyspepsia or irritable bowel syndrome HeatherAdministrator   07/24/04 02:17 PM
. * Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis HeatherAdministrator   07/24/04 01:42 PM
. * Irritable Bowel Syndrome Linked to High Rates of Various Surgeries HeatherAdministrator   07/11/04 02:15 PM
. * Drug-Free Ways to Treat IBS HeatherAdministrator   07/11/04 01:47 PM
. * Irritable Bowel Syndrome - An Evidence-Based Approach to Diagnosis HeatherAdministrator   06/27/04 01:14 PM
. * Biases Affect Treatment of IBS HeatherAdministrator   06/04/04 06:45 PM
. * Moms with Bowel Symptoms Take Baby to Doctor More HeatherAdministrator   05/25/04 11:53 AM
. * Natural History of Irritable Bowel Syndrome HeatherAdministrator   05/10/04 02:36 PM
. * Intestinal Gas May Contribute to IBS Symptoms HeatherAdministrator   05/10/04 02:29 PM
. * Are Your Bowels Irritable? IBS Awareness Month is Here HeatherAdministrator   04/09/04 07:11 PM
. * Heartburn May Not Reflect Gastroesophageal Reflux Disease Severity HeatherAdministrator   03/30/04 02:43 PM
. * A link between irritable bowel syndrome and fibromyalgia HeatherAdministrator   03/30/04 01:46 PM
. * Diverticular Disease: Electrophysiologic Study and a New Concept of Pathogenesis HeatherAdministrator   03/09/04 11:48 AM
. * New Syndrome Connects Gallbladder Dysfunction And Chronic Diarrhea HeatherAdministrator   03/09/04 11:45 AM
. * Researchers Pioneer Accessible, Cost-Effective Treatments for IBS HeatherAdministrator   03/08/04 06:48 PM
. * Splitting IBS: from original Rome to Rome II criteria HeatherAdministrator   02/10/04 02:35 PM
. * Utilization patterns and net direct medical cost to Medicaid of IBS HeatherAdministrator   02/10/04 02:34 PM
. * Family practitioners' attitudes and knowledge about IBS HeatherAdministrator   02/10/04 02:32 PM
. * The Effect of Somatization on Gastrointestinal and Extraintestinal Symptoms of IBS HeatherAdministrator   01/26/04 03:26 PM
. * Surgery and IBS HeatherAdministrator   01/26/04 03:21 PM
. * IBS Subgroups by Bowel Habit Predominance HeatherAdministrator   01/26/04 03:13 PM
. * Visceral perception thresholds in irritable bowel syndrome HeatherAdministrator   01/07/04 11:56 AM
. * Electric activity of the colon in irritable bowel syndrome HeatherAdministrator   01/07/04 11:52 AM
. * Irritable Bowel Syndrome's Possible Genetic Link HeatherAdministrator   01/07/04 11:40 AM
. * Intestinal gas distribution determines abdominal symptoms HeatherAdministrator   12/16/03 12:27 PM
. * Faecal incontinence - Many treatment options now exist HeatherAdministrator   12/16/03 12:17 PM
. * Abnormal Colonic Propagated Activity in Patients with Constipation HeatherAdministrator   12/16/03 12:07 PM
. * Colonic Propulsive Impairment in Intractable Slow-Transit Constipation HeatherAdministrator   12/16/03 12:03 PM
. * Overlapping upper and lower GI symptoms in IBS patients with constipation or diarrhea HeatherAdministrator   12/01/03 05:51 PM
. * Familial aggregation of irritable bowel syndrome HeatherAdministrator   12/01/03 05:49 PM
. * Outlook affects bowel disorder patients HeatherAdministrator   11/18/03 03:30 PM
. * Doctors unmoved by bowel misery HeatherAdministrator   11/18/03 03:28 PM
. * Travelers' Diarrhoea Can Trigger Irritable Bowel HeatherAdministrator   11/04/03 03:21 PM
. * Mind-Body Technique Eases Kids' Gut Pain HeatherAdministrator   10/30/03 11:17 AM
. * Molecular Alterations In Patients With Irritable Bowel Syndrome HeatherAdministrator   10/20/03 03:46 PM
. * Three in Four People With IBS Also Have Functional Dyspepsia HeatherAdministrator   10/15/03 03:28 PM
. * Infectious Gastroenteritis Linked to Irritable Bowel Syndrome HeatherAdministrator   09/30/03 02:27 PM
. * Association Between Pain Episodes & High Amplitude Pressure Waves in IBS HeatherAdministrator   09/16/03 03:54 PM
. * Constipation and its management HeatherAdministrator   09/16/03 03:41 PM
. * Contributions of suggestion, desire, and expectation to placebo effects in IBS patients HeatherAdministrator   09/16/03 03:28 PM
. * Do published guidelines for evaluation of IBS reflect practice? HeatherAdministrator   08/30/03 02:40 PM
. * Cognitive-behavioral therapy versus education and desipramine versus placebo for IBS HeatherAdministrator   08/12/03 12:54 PM
. * Distinctive features of postinfective irritable bowel syndrome HeatherAdministrator   07/28/03 03:18 PM
. * UCLA/CURE Neuroenteric Disease Program Newsletter HeatherAdministrator   07/23/03 10:38 AM
. * Bacterial Overgrowth in IBS HeatherAdministrator   07/18/03 12:15 PM
. * Diagnosis of irritable bowel syndrome. HeatherAdministrator   07/18/03 11:54 AM
. * Eradication of small intestinal bacterial overgrowth reduces symptoms of IBS HeatherAdministrator   07/18/03 11:44 AM
. * Antibiotics increase functional abdominal symptoms. HeatherAdministrator   07/18/03 11:41 AM
. * Treatment of the irritable bowel syndrome. HeatherAdministrator   07/15/03 11:02 PM
. * Extraintestinal symptoms in IBS and IBD HeatherAdministrator   07/15/03 06:21 PM
. * Postinfectious irritable bowel syndrome. HeatherAdministrator   07/15/03 06:19 PM
. * Dieting severity and GI symptoms in college women. HeatherAdministrator   07/15/03 01:13 PM
. * Functional GI disorders and eating disorders - Relevance of the association HeatherAdministrator   07/15/03 11:14 AM
. * Features of eating disorders in patients with IBS HeatherAdministrator   07/15/03 11:12 AM
. * New and Important Insights Into IBS HeatherAdministrator   07/14/03 03:24 PM
. * The Irritable Bowel Syndrome-Fibromyalgia Connection HeatherAdministrator   07/14/03 03:19 PM
. * Update on Treatment of Functional Gastrointestinal Disorders HeatherAdministrator   07/14/03 02:55 PM
. * Irritable bowel syndrome in primary care: The patients’ and doctors’ views HeatherAdministrator   07/14/03 02:43 PM
. * Inflammatory bowel disease and irritable bowel syndrome: separate or unified? HeatherAdministrator   07/14/03 02:32 PM

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