All Boards >> Irritable Bowel Syndrome Research Library

View all threads Posts     Flat     Threaded

IBD Patients May Benefit From Folic Acid Supplementation
      05/22/05 07:02 PM
HeatherAdministrator

Reged: 12/09/02
Posts: 7790
Loc: Seattle, WA

IBD Patients May Benefit From Folic Acid Supplementation

NEW YORK (Reuters Health) Apr 29 - Homocysteine levels are increased in both the mucosa and blood of patients with Crohn's disease and ulcerative colitis, according to a new study, suggesting that this molecule may play a pathogenic role in intestinal inflammation. Further, the effect could be abolished by folate supplementation.

Elevated homocysteine "contributes to the pathophysiology" of several chronic inflammatory diseases, investigators note in the April issue of the American Journal of Gastroenterology. But whether homocysteine is involved in mucosal inflammation in patients with inflammatory bowel disease (IBD) has not been explored, until now.

In their study of 83 patients with Crohn's, 83 with ulcerative colitis, and 70 healthy controls, plasma and mucosal homocysteine levels were significantly higher in IBD patients relative to control subjects.

Specifically, they observed that IBD-derived intestinal lamina propria mononuclear cells (LPMC) released higher homocysteine than control-derived LPMC.

Culturing intestinal microvascular endothelial cells in homocysteine alone, or in combination with TNF-alpha to mimic the in vivo IBD intestinal conditions, effectively triggered an inflammatory reaction in these cells, leading to upregulation of various endothelial cell adhesion molecules.

The team also observed low folate levels in the IBD patients. Folate levels were inversely correlated with homocysteine levels and, in in vitro studies, the addition of folic acid, a homocysteine scavenger, blocked the homocysteine-triggered inflammatory effects.

Therefore, Dr. Silvio Danese, from Catholic University in Rome, Italy and colleagues think it would be "reasonable to hypothesize a beneficial effect of folic acid supplementation in IBD patents to eliminate the homocysteine-mediated inflammatory events, especially mononuclear cell adhesion."

Am J Gastroenterol 2005;100:896-895.:


http://www.medscape.com/viewarticle/504063?src=mp

--------------------
Heather is the Administrator of the IBS Message Boards. She is the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

Print     Remind Me     Notify Moderator    

Entire thread
* Inflammatory Bowel Disease
HeatherAdministrator
07/14/03 01:51 PM
* Why cannabis relieves IBD symptoms
HeatherAdministrator
08/22/18 02:39 PM
* Dietary fiber associated with reduced Crohn's disease flares
HeatherAdministrator
01/27/16 02:58 PM
* Probiotics not superior for maintaining ulcerative colitis remission
HeatherAdministrator
12/29/15 10:12 AM
* Fecal transplant induces remission in active ulcerative colitis
HeatherAdministrator
07/16/15 04:39 PM
* 7 recent developments in Crohn's disease
HeatherAdministrator
04/02/15 03:16 PM
* Hormonal contraception improved menstrual-related IBD symptoms
HeatherAdministrator
09/15/14 12:43 PM
* Fecal lactoferrin differentiated IBD from IBS
HeatherAdministrator
07/29/14 01:50 PM
* Vitamin D and Cancer Risk in IBD
HeatherAdministrator
07/15/14 02:53 PM
* Self-assessment scale developed for patients with IBD-fatigue
HeatherAdministrator
06/17/14 10:44 AM
* Stool test distinguishes between IBD and IBS
HeatherAdministrator
04/07/14 01:40 PM
* Breathing exercises, meditation improved inflammatory markers, quality of life in IBD patients
HeatherAdministrator
10/23/13 04:20 PM
* Inflammatory Bowel Disease: Heat Waves Linked to Flares
HeatherAdministrator
08/16/13 12:58 PM
* Dietary changes may reduce effects of IBD
HeatherAdministrator
06/27/13 05:43 PM
* Genetic Clues May Help Unravel Cause of Crohn's
HeatherAdministrator
11/02/12 12:59 PM
* Inflammatory bowel, ulcerative colitis linked to intestinal fungi
HeatherAdministrator
06/15/12 01:23 PM
* Smoking makes Crohn's disease worse
HeatherAdministrator
05/09/12 01:33 PM
* Kids With Crohn’s Disease, Colitis Often Struggle at School
HeatherAdministrator
04/23/12 01:22 PM
* As Nations Develop, So May Bowel Disease
HeatherAdministrator
01/09/12 12:01 PM
* Loneliness Triggers Inflammatory Illnesses
HeatherAdministrator
02/10/11 10:05 AM
* Infants' antibiotic use tied to IBD risk
HeatherAdministrator
11/03/10 01:42 PM
* Olive Oil May Protect Against Ulcerative Colitis
HeatherAdministrator
05/05/10 10:32 AM
* Accutane may cause ulcerative colitis
HeatherAdministrator
04/09/10 01:38 PM
* Red meat may raise odds for ulcerative colitis, but oily fish could be protective
HeatherAdministrator
03/11/10 01:22 PM
* Inflammatory Bowel Disease and Irritable Bowel Syndrome: Separate or Unified?
HeatherAdministrator
01/05/10 12:03 PM
* Novel Compound Targets Mucosal Healing in Crohn's
HeatherAdministrator
05/29/06 02:19 PM
* Viagra May Help Crohn's Disease
HeatherAdministrator
03/04/06 12:50 PM
* Carbon Monoxide Eases Ulcerative Colitis
HeatherAdministrator
01/18/06 04:12 PM
* Colonoscopic Surveillance in Inflammatory Bowel Disease
HeatherAdministrator
10/11/05 01:33 PM
* Oral Contraceptives and HRT a Risk Factor for Inflammatory Bowel Disease
HeatherAdministrator
09/13/05 01:22 PM
* Cannabinoids Show Promise for Inflammatory Bowel Disease
HeatherAdministrator
09/01/05 11:23 AM
* Differentiation of Inflammatory Bowel Disease and Irritable Bowel Syndrome
HeatherAdministrator
09/01/05 11:13 AM
* The Clinical Epidemiology of Inflammatory Bowel Disease
HeatherAdministrator
08/22/05 04:45 PM
* IBD Patients May Benefit From Folic Acid Supplementation
HeatherAdministrator
05/22/05 07:02 PM
* Fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis
HeatherAdministrator
04/24/05 03:33 PM
* Biotic Therapy Cuts Inflammation in Ulcerative Colitis
HeatherAdministrator
02/19/05 05:59 PM
* Calming Crohn's Disease with Fish Oil and Antioxidants
HeatherAdministrator
01/07/05 04:55 PM
* Probiotics Prove Just As Effective As a Popular Prescription Drug for Ulcerative Colitis
HeatherAdministrator
12/20/04 01:37 PM
* Increased Incidence of Inflammatory Bowel Disease: The Price of the Decline of Infectious Burden?
HeatherAdministrator
11/28/04 02:58 PM
* Diet May Influence Relapse in Ulcerative Colitis
HeatherAdministrator
10/24/04 07:50 PM
* Parasite Therapy for Crohn's and Colitis?
HeatherAdministrator
08/08/04 03:00 PM
* Pipeline Treatments, Novel Procedures Offer New Options for GI Diseases
HeatherAdministrator
06/04/04 06:41 PM
* Faulty Gene for Crohn's Disease Found
HeatherAdministrator
04/13/04 03:19 PM
* Data links Crohn's disease and antibiotics
HeatherAdministrator
02/24/04 02:07 PM
* Elan Reports Successful Results of Antegren Trial for Crohn's Disease
HeatherAdministrator
02/10/04 01:30 PM
* 5-ASA Therapy for Inflammatory Bowel Disease No Bar to Colon Cancer
HeatherAdministrator
02/10/04 01:29 PM
* Once-Daily Probiotic Treatment Maintains Remission in Ulcerative Colitis patients with Pouchitis
HeatherAdministrator
01/26/04 03:33 PM
* Bone Disease and Intestinal Problems May Share a Common Cause
HeatherAdministrator
01/07/04 11:47 AM
* Increased Anal Resting Pressure and Rectal Sensitivity in Crohn's Disease
HeatherAdministrator
12/16/03 11:59 AM
* Environmental Factors May Play a Role in the Pathogenesis of IBD
HeatherAdministrator
12/01/03 05:56 PM
* Colonoscopy Prep
HeatherAdministrator
10/17/03 12:05 PM
* Detection of Pulmonary Involvement in Inflammatory Bowel Disease
HeatherAdministrator
09/30/03 01:20 PM
* Indeterminate Colitis
HeatherAdministrator
09/16/03 03:33 PM
* Familial Occurrence of Inflammatory Bowel Disease in Celiac Disease
HeatherAdministrator
09/16/03 03:30 PM
* Bacteria in Milk Linked to Crohn's Disease and Possibly IBS
HeatherAdministrator
08/12/03 11:55 AM
* Inflammatory Bowel Disease During Pregnancy.
HeatherAdministrator
07/15/03 06:20 PM
* A study of the menopause, smoking, and contraception in women with Crohn's disease.
HeatherAdministrator
07/15/03 06:05 PM
* Hormone replacement therapy prevents bone loss in patients with IBD
HeatherAdministrator
07/15/03 06:02 PM
* Chemo Drug Improves Crohn's Symptoms
HeatherAdministrator
07/14/03 04:09 PM

Extra information
0 registered and 91 anonymous users are browsing this forum.

Moderator:  Heather 



Permissions
      You cannot post until you login
      You cannot reply until you login
      HTML is enabled
      UBBCode is enabled

Thread views: 257918

Jump to

| Privacy statement Help for IBS Home

*
UBB.threads™ 6.2


McAfee SECURE sites help keep you safe from identity theft, credit card fraud, spyware, spam, viruses and online scams

HelpForIBS.com BBB Business Review