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IBD Patients May Benefit From Folic Acid Supplementation       05/22/05 07:02 PM Edit Reply Quote Heather Reged: 12/09/02 Posts: 7799 Loc: Seattle, WA IBD Patients May Benefit From Folic Acid Supplementation NEW YORK (Reuters Health) Apr 29 - Homocysteine levels are increased in both the mucosa and blood of patients with Crohn's disease and ulcerative colitis, according to a new study, suggesting that this molecule may play a pathogenic role in intestinal inflammation. Further, the effect could be abolished by folate supplementation. Elevated homocysteine "contributes to the pathophysiology" of several chronic inflammatory diseases, investigators note in the April issue of the American Journal of Gastroenterology. But whether homocysteine is involved in mucosal inflammation in patients with inflammatory bowel disease (IBD) has not been explored, until now. In their study of 83 patients with Crohn's, 83 with ulcerative colitis, and 70 healthy controls, plasma and mucosal homocysteine levels were significantly higher in IBD patients relative to control subjects. Specifically, they observed that IBD-derived intestinal lamina propria mononuclear cells (LPMC) released higher homocysteine than control-derived LPMC. Culturing intestinal microvascular endothelial cells in homocysteine alone, or in combination with TNF-alpha to mimic the in vivo IBD intestinal conditions, effectively triggered an inflammatory reaction in these cells, leading to upregulation of various endothelial cell adhesion molecules. The team also observed low folate levels in the IBD patients. Folate levels were inversely correlated with homocysteine levels and, in in vitro studies, the addition of folic acid, a homocysteine scavenger, blocked the homocysteine-triggered inflammatory effects. Therefore, Dr. Silvio Danese, from Catholic University in Rome, Italy and colleagues think it would be "reasonable to hypothesize a beneficial effect of folic acid supplementation in IBD patents to eliminate the homocysteine-mediated inflammatory events, especially mononuclear cell adhesion." Am J Gastroenterol 2005;100:896-895.: http://www.medscape.com/viewarticle/504063?src=mp -------------------- Heather is the Administrator of the IBS Message Boards. She is the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook! Print     Remind Me     Notify Moderator

Entire thread Inflammatory Bowel Disease Heather 07/14/03 01:51 PM Why cannabis relieves IBD symptoms Heather 08/22/18 02:39 PM Dietary fiber associated with reduced Crohn's disease flares Heather 01/27/16 02:58 PM Probiotics not superior for maintaining ulcerative colitis remission Heather 12/29/15 10:12 AM Fecal transplant induces remission in active ulcerative colitis Heather 07/16/15 04:39 PM 7 recent developments in Crohn's disease Heather 04/02/15 03:16 PM Hormonal contraception improved menstrual-related IBD symptoms Heather 09/15/14 12:43 PM Fecal lactoferrin differentiated IBD from IBS Heather 07/29/14 01:50 PM Vitamin D and Cancer Risk in IBD Heather 07/15/14 02:53 PM Self-assessment scale developed for patients with IBD-fatigue Heather 06/17/14 10:44 AM Stool test distinguishes between IBD and IBS Heather 04/07/14 01:40 PM Breathing exercises, meditation improved inflammatory markers, quality of life in IBD patients Heather 10/23/13 04:20 PM Inflammatory Bowel Disease: Heat Waves Linked to Flares Heather 08/16/13 12:58 PM Dietary changes may reduce effects of IBD Heather 06/27/13 05:43 PM Genetic Clues May Help Unravel Cause of Crohn's Heather 11/02/12 12:59 PM Inflammatory bowel, ulcerative colitis linked to intestinal fungi Heather 06/15/12 01:23 PM Smoking makes Crohn's disease worse Heather 05/09/12 01:33 PM Kids With Crohn’s Disease, Colitis Often Struggle at School Heather 04/23/12 01:22 PM As Nations Develop, So May Bowel Disease Heather 01/09/12 12:01 PM Loneliness Triggers Inflammatory Illnesses Heather 02/10/11 10:05 AM Infants' antibiotic use tied to IBD risk Heather 11/03/10 01:42 PM Olive Oil May Protect Against Ulcerative Colitis Heather 05/05/10 10:32 AM Accutane may cause ulcerative colitis Heather 04/09/10 01:38 PM Red meat may raise odds for ulcerative colitis, but oily fish could be protective Heather 03/11/10 01:22 PM Inflammatory Bowel Disease and Irritable Bowel Syndrome: Separate or Unified? Heather 01/05/10 12:03 PM Novel Compound Targets Mucosal Healing in Crohn's Heather 05/29/06 02:19 PM Viagra May Help Crohn's Disease Heather 03/04/06 12:50 PM Carbon Monoxide Eases Ulcerative Colitis Heather 01/18/06 04:12 PM Colonoscopic Surveillance in Inflammatory Bowel Disease Heather 10/11/05 01:33 PM Oral Contraceptives and HRT a Risk Factor for Inflammatory Bowel Disease Heather 09/13/05 01:22 PM Cannabinoids Show Promise for Inflammatory Bowel Disease Heather 09/01/05 11:23 AM Differentiation of Inflammatory Bowel Disease and Irritable Bowel Syndrome Heather 09/01/05 11:13 AM The Clinical Epidemiology of Inflammatory Bowel Disease Heather 08/22/05 04:45 PM IBD Patients May Benefit From Folic Acid Supplementation Heather 05/22/05 07:02 PM Fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis Heather 04/24/05 03:33 PM Biotic Therapy Cuts Inflammation in Ulcerative Colitis Heather 02/19/05 05:59 PM Calming Crohn's Disease with Fish Oil and Antioxidants Heather 01/07/05 04:55 PM Probiotics Prove Just As Effective As a Popular Prescription Drug for Ulcerative Colitis Heather 12/20/04 01:37 PM Increased Incidence of Inflammatory Bowel Disease: The Price of the Decline of Infectious Burden? Heather 11/28/04 02:58 PM Diet May Influence Relapse in Ulcerative Colitis Heather 10/24/04 07:50 PM Parasite Therapy for Crohn's and Colitis? Heather 08/08/04 03:00 PM Pipeline Treatments, Novel Procedures Offer New Options for GI Diseases Heather 06/04/04 06:41 PM Faulty Gene for Crohn's Disease Found Heather 04/13/04 03:19 PM Data links Crohn's disease and antibiotics Heather 02/24/04 02:07 PM Elan Reports Successful Results of Antegren Trial for Crohn's Disease Heather 02/10/04 01:30 PM 5-ASA Therapy for Inflammatory Bowel Disease No Bar to Colon Cancer Heather 02/10/04 01:29 PM Once-Daily Probiotic Treatment Maintains Remission in Ulcerative Colitis patients with Pouchitis Heather 01/26/04 03:33 PM Bone Disease and Intestinal Problems May Share a Common Cause Heather 01/07/04 11:47 AM Increased Anal Resting Pressure and Rectal Sensitivity in Crohn's Disease Heather 12/16/03 11:59 AM Environmental Factors May Play a Role in the Pathogenesis of IBD Heather 12/01/03 05:56 PM Colonoscopy Prep Heather 10/17/03 12:05 PM Detection of Pulmonary Involvement in Inflammatory Bowel Disease Heather 09/30/03 01:20 PM Indeterminate Colitis Heather 09/16/03 03:33 PM Familial Occurrence of Inflammatory Bowel Disease in Celiac Disease Heather 09/16/03 03:30 PM Bacteria in Milk Linked to Crohn's Disease and Possibly IBS Heather 08/12/03 11:55 AM Inflammatory Bowel Disease During Pregnancy. Heather 07/15/03 06:20 PM A study of the menopause, smoking, and contraception in women with Crohn's disease. Heather 07/15/03 06:05 PM Hormone replacement therapy prevents bone loss in patients with IBD Heather 07/15/03 06:02 PM Chemo Drug Improves Crohn's Symptoms Heather 07/14/03 04:09 PM

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