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Celiac disease: fertility and pregnancy.
      07/15/03 06:14 PM
HeatherAdministrator

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Gynecol Obstet Invest. 2001;51(1):3-7.

Celiac disease: fertility and pregnancy.

Eliakim R, Sherer DM.

Division of Gastroenterology, Rambam Medical Center, Technion School of Medicine, Haifa, Israel.

Celiac disease (gluten-sensitive enteropathy) may manifest clinically with an array of nongastrointestinal symptoms among which are: dermatitis herpetiformis; dementia; depression; various neurological symptoms; osteoporosis; osteomalacia; dental enamel defects, and anemia of various types. Important data have accumulated in recent years regarding the association between celiac disease, fertility and pregnancy. Many primary care obstetricians and gynecologists and perinatologists are not aware of these important relationships. The aim of this review, utilizing a MEDLINE search from 1966 through March 2000 of the English language, is to describe the possible effects of celiac disease and its treatment upon the reproductive cycle, fertility, pregnancy, and menopause. Review of the literature reveals that patients with untreated celiac disease sustain a significantly delayed menarche, earlier menopause, and an increased prevalence of secondary amenorrhea. Patients with untreated celiac disease incur higher miscarriage rates, increased fetal growth restriction, and lower birth weights. It appears that improvement of celiac disease, as reflected by restoration of small bowel mucosa associated with implementation of a gluten-free diet, may decrease miscarriage rates, improve fetal nutritional support and overall perinatal outcome. Copyright 2001 S. Karger AG, Basel.

Publication Types:
Review
Review, Tutorial

PMID: 11150866 [PubMed - indexed for MEDLINE]
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