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Dietary fibre in food and protection against colorectal cancer       07/14/03 03:21 PM Edit Reply Quote Heather Reged: 12/09/02 Posts: 7799 Loc: Seattle, WA CardioSource 3 May 2003, Volume 361, Issue 9368 Pages 1496-1501 Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study Sheila A Bingham a, Nicholas E Day b, Robert Luben b, Pietro Ferrari c, Nadia Slimani c, Teresa Norat c, Françoise Clavel-Chapelon d, Emmanuelle Kesse d, Alexandra Nieters e, Heiner Boeing f, Anne Tjønneland g, Kim Overvad h,i, Carmen Martinez j, Miren Dorronsoro k, Carlos A Gonzalez l, Timothy J Key m, Antonia Trichopoulou n, Androniki Naska n, Paolo Vineis o, Rosario Tumino p, Vittorio Krogh q, H Bas Bueno-de-Mesquita r, Petra HM Peeters s, Göran Berglund t, Göran Hallmans u, Eiliv Lund v, Guri Skeie v, Rudolf Kaaks c and Elio Riboli c * Abstract Background Dietary fibre is thought to protect against colorectal cancer but this view has been challenged by recent prospective and intervention studies that showed no protective effect. Methods We prospectively examined the association between dietary fibre intake and incidence of colorectal cancer in 519978 individuals aged 25–70 years taking part in the EPIC study, recruited from ten European countries. Participants completed a dietary questionnaire in 1992–98 and were followed up for cancer incidence. Relative risk estimates were obtained from fibre intake, categorised by sex-specific, cohort-wide quintiles, and from linear models relating the hazard ratio to fibre intake expressed as a continuous variable. Findings Follow-up consisted of 1939011 person-years, and data for 1065 reported cases of colorectal cancer were included in the analysis. Dietary fibre in foods was inversely related to incidence of large bowel cancer (adjusted relative risk 0·75 [95% CI 0·59–0·95] for the highest versus lowest quintile of intake), the protective effect being greatest for the left side of the colon, and least for the rectum. After calibration with more detailed dietary data, the adjusted relative risk for the highest versus lowest quintile of fibre from food intake was 0·58 (0·41–0·85). No food source of fibre was significantly more protective than others, and non-food supplement sources of fibre were not investigated. Interpretation In populations with low average intake of dietary fibre, an approximate doubling of total fibre intake from foods could reduce the risk of colorectal cancer by 40%. -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Affiliations a MRC Dunn Human Nutrition Unit, Cambridge, UK. b Strangeways Research Laboratory, University of Cambridge, Cambridge, UK. c International Agency for Research on Cancer (IARC-WHO), Lyon, France. d INSERM, U 521, Institut Gustave Roussy, Villejuif, France. e German Cancer Research Centre, Heidelberg, Germany. f German Institute of Human Nutrition, Potsdam-Rehbücke, Germany. g Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. h Department of Clinical Epidemiology, Aalborg Hospital and Aarhus University Hospital, Denmark. i Department of Epidemiology and Social Medicine, University of Aarhus, Denmark. j Andalusian School of Public Health, Granada, Spain. k Department of Public Health of Guipuzkoa, San Sebastian, Spain. l Catalan Institute of Oncology, Barcelona, Spain. m Cancer Research UK, Radcliffe Infirmary, Oxford, UK. n University of Athens Medical School, Greece. o University of Torino and CPO-Piemonte, Torino, Italy. p Ragusa Cancer Registry, Sicily, Italy. q Department of Epidemiology, National Cancer Institute, Milan, Italy. r National Institute of Public Health and the Environment, Bilthoven, Netherlands. s Julius Centre for Health Sciences and Primary Care, University Medical Center, Netherlands. t Malmö Diet and Cancer Study, Lund University, Malmö, Sweden. u Department of Nutritional Research, University of Umeå, Sweden. v Institute of Community Medicine, University of Tromsø, Norway. -------------------------------------------------------------------------------- * Correspondence to: Dr Elio Riboli, Unit of Nutrition and Cancer, International Agency for Research on Cancer (IARC-WHO), 150 Cours Albert-Thomas, 69372 Lyon cedex 08, France Source Elsevier Science Inc. © 2003 Elsevier Science Ltd web page -------------------- Heather is the Administrator of the IBS Message Boards. She is the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook! Print     Remind Me     Notify Moderator

Entire thread Diet Heather 07/14/03 01:58 PM When IBS leads to eating disorders in young people Heather 06/28/22 01:49 PM Complicated relationship exists between IBS and low FODMAP diet Heather 04/23/19 02:53 PM Insufficient evidence to support gluten-free diet for IBS Heather 08/08/18 03:35 PM Prebiotics vs a Diet Low in Fodmaps in Patients with Functional Gut Disorder Heather 07/18/18 02:58 PM Diet, lifestyle outweigh genetic impact on gut microbiome Heather 03/19/18 02:39 PM Fecal Profiling May Predict Dietary Response in IBS to FODMAPS Diet Heather 03/15/18 11:51 AM Can a Western diet permanently alter the immune system? Heather 01/19/18 01:17 PM High-fat diet leads to same intestinal inflammation as a virus Heather 06/23/17 04:25 PM Gluten-free diet could increase cardiovascular risk in people without celiac disease Heather 05/09/17 01:35 PM Gut microbiome profiles predict response to low FODMAP diet in IBS Heather 11/02/16 02:45 PM Fructose malabsorption, symptom severity, IBS subtype predict response to low FODMAP diet Heather 06/27/16 02:44 PM Fiber-Rich Diet May Boost Lung Function Heather 01/27/16 02:52 PM 'Very limited evidence' to show FODMAPS diet helps IBS Heather 08/07/15 11:56 AM Intestinal Microbiota And Diet in IBS Heather 01/27/15 11:50 AM Low-FODMAP diet NOT superior to traditional diet for reducing IBS symptoms Heather 11/24/14 10:17 AM Rapid increase in IBD caused by dietary trigger? Heather 10/07/14 02:34 PM FODMAPS diet reduces good gut bacteria levels Heather 08/04/14 04:25 PM White bread good for the gut Heather 06/24/14 12:03 PM IBS diet quick tip - HOW to eat for IBS Heather 04/01/14 04:25 PM Dairy and IBS Heather 03/11/14 02:12 PM Soda pop and IBS Heather 03/11/14 02:11 PM Popular blood type diet debunked Heather 01/17/14 11:51 AM Chowing Down On Meat, Dairy Alters Gut Bacteria A Lot Heather 12/11/13 02:20 PM Non-Celiac Wheat Sensitivity in IBS May Be a Food Allergy Heather 11/13/13 12:02 PM Red meat linked to Barrett’s esophagus risk Heather 09/06/13 12:03 PM 16 Foods that May Help Fight Acid Reflux Heather 08/23/13 01:38 PM Coconut Oil for IBS? Heather 08/16/13 01:02 PM Spicy Foods and IBS Heather 08/16/13 12:59 PM Soy foods protect against colon cancer Heather 08/06/13 10:09 AM A Tale of Two Fibers Heather 06/28/13 01:42 PM Yet another reason to not skip breakfast Heather 06/18/13 11:24 AM Less Meat = Longer Life Heather 06/12/13 05:18 PM Limiting poorly digested carbs called FODMAPS may help ease irritable bowel syndrome Heather 05/22/13 02:55 PM Fluids may prevent constipation better than anything Heather 05/21/13 01:46 PM Fried foods have similar impact on your liver as hepatitis Heather 02/20/13 10:26 AM Taming Stomachs With Fodmap Diet Spurs $8 Billion Market Heather 10/31/12 11:39 AM Green tea drinkers show lower cancer risks Heather 10/31/12 11:37 AM Atkins Low Carb-High Protein Diets May Put Heart at Risk Heather 06/27/12 02:36 PM Milk fat may lead to bowel diseases by altering gut bacteria Heather 06/19/12 04:25 PM Buddhist mindful eating practices enter the mainstream Heather 06/15/12 03:17 PM High levels of fructose can damage liver Heather 06/15/12 03:15 PM Vegetarian diet provides good nutrition, health benefits, study finds Heather 06/15/12 03:04 PM Doubts cast on food intolerance testing Heather 05/03/12 03:19 PM Starchy foods cut bowel cancer risk Heather 05/02/12 10:34 AM Worldwide prevalence of lactose intolerance Heather 05/02/12 10:31 AM Eating fish tied to lower risk of colon polyps Heather 04/23/12 01:25 PM Dietary and other modifiable risk factors may account for as many as 90 percent of colorectal cancers Heather 04/23/12 01:14 PM Helpful Gut Microbes May Differ Based on Diet Heather 09/07/11 12:16 PM Soluble Fiber Appears Key to Trimming Bad Body Fat Heather 07/06/11 11:52 AM Colon response to food is abnormal in irritable bowel syndrome Heather 04/19/11 01:42 PM Red meat linked to cancer risks Heather 11/10/10 11:24 AM White Rice for Functional Constipation Heather 10/13/10 02:53 PM Adding gluten early may cause constipation in babies Heather 03/12/10 11:31 AM Processed Meat May Harm the Heart Heather 03/12/10 11:27 AM Increasing Soda Consumption Fuels Rise in Diabetes, Heart Disease Heather 03/12/10 11:26 AM Strategy to combat cancer: Avoid meats and dairy products Heather 03/05/10 12:25 PM Dietary Fiber May Help Prevent Weight Gain & Obesity Heather 03/05/10 12:16 PM Soluble Fiber Helps IBS, Insoluble Fiber Hurts Heather 09/16/09 01:53 PM IBS Diet Cheat Sheet Celebrates 1 Million Downloads by Irritable Bowel Syndrome Patients Heather 06/12/09 11:09 AM Meat intake and mortality Heather 04/30/09 01:16 PM Dietary changes highly acceptable to IBS patients Heather 03/18/09 05:51 PM Role of dietary fructose and fructans in initiating symptoms of IBS in fructose malabsorbers Heather 08/07/08 12:20 PM Therapeutic effects of eliminating allergic foods according to food-specific IgG antibodies in irritable bowel syndrome Heather 11/07/07 02:42 PM Is there any food I can eat? Living with inflammatory bowel disease and/or irritable bowel syndrome. Heather 06/20/07 02:16 PM More GI Symptoms, Less Anxiety With Tryptophan Supplementation in IBS Heather 04/28/07 10:18 AM Abnormalities of GI transit in bloated irritable bowel syndrome: effect of bran Heather 12/01/06 02:08 PM Influence of alcohol consumption on IBS and dyspepsia Heather 10/26/06 10:39 AM Dietary means of diagnosing IBS Heather 02/01/06 12:10 PM No evidence that soy estrogens increase cancer risk Heather 02/01/06 11:53 AM Organic Diets Significantly Lower Children’s Dietary Exposure to Organophosphorus Pesticides Heather 01/08/06 05:21 PM Carbonated Soft Drink Consumption and Risk of Esophageal Adenocarcinoma Heather 01/08/06 04:40 PM Utility of Glycemic Index / Glycemic Load Questioned Heather 09/13/05 01:10 PM IBS Sufferers Hypersensitive to Common Foods Heather 06/30/05 04:05 PM Fruit, vegetable juices may stall Alzheimer's disease Heather 06/20/05 04:16 PM UK investigates dietary management of constipation Heather 06/05/05 05:45 PM Fructose intolerance in IBS could lead to fructose-free products Heather 04/10/05 06:45 PM Fats and visceral sensitivity In IBS patients Heather 03/04/05 11:50 AM Grapefruit Juice Can Interact With Medicines Heather 02/06/05 02:41 PM Red Meat Consumption Linked to Colorectal Cancer Heather 01/23/05 05:12 PM Dietary Fiber and GERD Heather 01/23/05 04:51 PM Higher Fiber Shown To Reduce Estrogen Levels Heather 01/07/05 05:00 PM Psyllium increases gas production and promotes gas retention Heather 11/28/04 02:43 PM Soy could stop spread of breast cancer Heather 11/08/04 04:10 PM Vegetarian Diet With Soy and Soluble Fiber Lowers Cholesterol Heather 10/28/04 07:09 PM Soy is unlikely to damage fertility in women Heather 10/24/04 07:27 PM Health-promoting compounds found in honey Heather 10/24/04 07:17 PM Food Elimination Based on IgG Antibodies Helpful in Irritable Bowel Syndrome Heather 10/11/04 04:24 PM The Lowdown on Low Carbs Heather 10/11/04 04:00 PM Nut Consumption and Decreased Risk of Gallbladder Removal in Women Heather 09/26/04 03:12 PM Yogurt and gut function Heather 09/26/04 03:06 PM Cranberry Juice Found to Help Prevent Peptic Ulcers Heather 09/26/04 02:51 PM High-Fiber, Low-Fat Diet Helps Calcium Prevent Colon Cancer Heather 08/30/04 01:18 PM Herbs are an Abundant Source of Antioxidants Heather 08/08/04 03:17 PM Soybean protein reduces body fat and triglycerides in women Heather 08/08/04 03:12 PM Soy Cuts Risk of Endometrial Cancer Heather 07/24/04 02:23 PM Alpha-Linoleic Acid in Walnuts Good for Cardiovascular Health Heather 07/24/04 02:02 PM New list of the 20 most antioxidant-rich foods Heather 07/11/04 02:26 PM Effect of fiber source on Clostridium difficile Heather 07/11/04 01:32 PM High Protein Diet May Affect Female Fertility Heather 07/11/04 01:08 PM Green Tea and Fruits May Have a Large Impact on GI Health Heather 06/04/04 06:35 PM GI HEALTH AFFECTED BY CONSUMPTION OF COFFEE AND CARBONATED DRINKS Heather 06/04/04 06:30 PM Bad news for low-carb dieters Heather 05/25/04 12:41 PM Cancer Society Promotes Disease with Beef Fundraisers, Say Doctors Heather 05/25/04 12:37 PM Too Much Drinking Could Serve Up Colon Cancer Heather 05/25/04 12:18 PM Nutrition experts push trans fats ban - Say trans-fats are disastrous for your health. Heather 05/25/04 12:08 PM Low-carb diets increase demand for laxatives Heather 05/10/04 12:59 PM Systematic Review: The Role of Different Types of Fibre in IBS Heather 03/30/04 02:56 PM High fructose corn syrup a major culprit in the nation's obesity crisis Heather 03/09/04 11:37 AM While health foods may seem expensive, healthy diets save money in the long run Heather 03/08/04 06:50 PM Stress May Lead To Food Allergies Heather 03/08/04 06:45 PM McDonald's has documentary beef Heather 02/24/04 02:26 PM Low Carb Diets are a Prescription for Prebiotics Heather 02/24/04 12:49 PM Effects of a Low-Fat, High-Carbohydrate Diet on Body Weight Heather 01/26/04 05:28 PM Fat, Fructose May Contribute to IBS Symptoms Heather 10/15/03 03:31 PM Fructose may play role in irritable bowel syndrome Heather 10/13/03 12:11 PM Essential Oils as Components of a Diet-Based Approach to Management of Helicobacter Infection Heather 09/30/03 01:34 PM High Fiber, Low Fat Diet Reduces Estrogen Levels & Breast Cancer Risk Heather 09/30/03 12:56 PM Milk Slows Recovery from Bowel Surgery Heather 09/16/03 04:03 PM Water Works - Soluble Fiber and Heart Disease Heather 09/16/03 11:43 AM Cows milk consumption in constipation and anal fissure in infants and young children Heather 08/12/03 12:03 PM Intestinal gas production from bacterial fermentation of undigested carbohydrate in IBS Heather 07/18/03 12:05 PM Fructose- and sorbitol-reduced diet improves mood and gastrointestinal disturbances Heather 07/18/03 11:58 AM Beneficial health effects of low-digestible carbohydrate consumption. Heather 07/18/03 11:56 AM Calcium polycarbophil compared with placebo in IBS Heather 07/15/03 11:10 PM Nutritional therapy of irritable bowel syndrome. Heather 07/15/03 11:05 PM Rice Demonstrates a Preventive Effect on Constipation Heather 07/14/03 04:05 PM High-Protein Diets Can Hurt Kidneys Heather 07/14/03 04:01 PM Diet and the irritable bowel syndrome. Heather 07/14/03 03:44 PM Bran and irritable bowel syndrome: time for reappraisal Heather 07/14/03 03:41 PM Bran: may irritate irritable bowel Heather 07/14/03 03:37 PM Wheat bran vs. partially hydrolyzed guar gum for IBS patients Heather 07/14/03 03:34 PM Dietary fibre in food and protection against colorectal cancer Heather 07/14/03 03:21 PM Eating Food Too Fast Speeds Heartburn Heather 07/14/03 02:57 PM Glycemic Load, Carbohydrate Intake, and Risk of Colorectal Cancer in Women Heather 07/14/03 02:37 PM

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