All Boards >> Irritable Bowel Syndrome Research Library

View all threads Posts     Flat     Threaded

Sex-related differences in IBS patients: Central processing of visceral stimuli
      07/14/03 02:40 PM
HeatherAdministrator

Reged: 12/09/02
Posts: 7793
Loc: Seattle, WA

Gastroenterology June 2003 • Volume 124 • Number 7

Sex-related differences in IBS patients: Central processing of visceral stimuli

Bruce D. Naliboff*,‡ * [MEDLINE LOOKUP]
Steve Berman*,‡,§ [MEDLINE LOOKUP]
Lin Chang*, § [MEDLINE LOOKUP]
Stuart W.G. Derbyshire* [MEDLINE LOOKUP]
Brandall Suyenobu*,‡ [MEDLINE LOOKUP]
Brent A. Vogt'' [MEDLINE LOOKUP]
Mark Mandelkern¶ [MEDLINE LOOKUP]
Emeran A. Mayer*,‡,§,¶,# [MEDLINE LOOKUP]

Abstract

Background & Aims: Women have a higher prevalence of irritable bowel syndrome (IBS) and possible differences in response to treatment, suggesting sex-related differences in underlying pathophysiology. The aim of this study was to determine possible sex-related differences in brain responses to a visceral and a psychological stressor in IBS.

Methods: Regional cerebral blood flow measurements using H215O positron emission tomography were compared across 23 female and 19 male nonconstipated patients with IBS during a visceral stimulus (moderate rectal inflation) and a psychological stimulus (anticipation of a visceral stimulus).

Results: In response to the visceral stimulus, women showed greater activation in the ventromedial prefrontal cortex, right anterior cingulate cortex, and left amygdala, whereas men showed greater activation of the right dorsolateral prefrontal cortex, insula, and dorsal pons/periaqueductal gray. Similar differences were observed during the anticipation condition. Men also reported higher arousal and lower fatigue.

Conclusions: Male and female patients with IBS differ in activation of brain networks concerned with cognitive, autonomic, and antinociceptive responses to delivered and anticipated aversive visceral stimuli.

Publishing and Reprint Information

*Center for Neurovisceral Sciences and Women's Health UCLA School of Medicine, Los Angeles, California, USA
§Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
‡Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California, USA
#Department of Physiology, UCLA School of Medicine, Los Angeles, California, USA
''Brain Research Institute, UCLA School of Medicine, and VA GLAHS PET Center, Los Angeles, California, USA
''Cingulum NeuroSciences Institute, Syracuse, New York, USA

Supported by National Institutes of Health grants NR 04881 (to B.D.N.), DK 64539 (to E.A.M.), and AR 46122 (to L.C.). Lin Chang received research support from Astra Zeneca, participates in the Speaker's Bureau for GSK and Novartis, and is on the Advisory Board for GSK and Merck. Dr. Derbyshire's current address is: University of Pittsburgh Medical Center, MR Research Facility, PUH B-804, Pittsburgh, Pennsylvania 15213.

*Address requests for reprints to: Bruce D. Naliboff, Ph.D., GLAVAHS, CURE Building, 115/Room 223, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA; fax: (310) 794-2864; Email: naliboff@ucla.edu

Submitted June 18, 2002.

Accepted on February 27, 2003.

Copyright © 2003 by American Gastroenterological Association

doi:10.1016/S0016-5085(03)00400-1

web page


--------------------
Heather is the Administrator of the IBS Message Boards. She is the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

Print     Remind Me     Notify Moderator    

Entire thread
* Gender / Hormones
HeatherAdministrator
07/14/03 01:57 PM
* Pain management in women is often overlooked and ineffective
HeatherAdministrator
02/16/15 04:42 PM
* Women, Hormones and IBS
HeatherAdministrator
03/11/14 02:09 PM
* Fennel is an effective herbal drug for menstrual pain
HeatherAdministrator
08/27/13 11:29 AM
* Constipation and Risk of Cardiovascular Disease among Postmenopausal Women
HeatherAdministrator
08/03/11 03:58 PM
* Differences in Gastrointestinal Symptoms According to Gender in Rome II Positive IBS and Dyspepsia
HeatherAdministrator
03/11/10 01:51 PM
* Gender-related differences in prepulse inhibition of startle in irritable bowel syndrome
HeatherAdministrator
03/11/10 01:48 PM
* No evidence of sex differences in heritability of irritable bowel syndrome
HeatherAdministrator
03/31/08 11:36 AM
* Acupuncture for the treatment of pain from a gender perspective.
HeatherAdministrator
03/31/08 11:27 AM
* The menstrual cycle and its effect on inflammatory bowel disease and irritable bowel syndrome
HeatherAdministrator
11/07/07 02:35 PM
* Irritable Bowel Syndrome Is More Common in Women Regardless of the Menstrual Phase
HeatherAdministrator
11/07/07 02:31 PM
* Pelvic floor dysfunction and IBS in patients with interstitial cystitis.
HeatherAdministrator
10/10/07 12:33 PM
* Women with IBS have abnormal pain modulation
HeatherAdministrator
10/10/07 12:01 PM
* Anxiety or Depression with IBS Affects More Women Than Men
HeatherAdministrator
09/24/07 11:31 AM
* Colonoscopies more difficult and painful for women and people with IBS
HeatherAdministrator
09/24/07 11:22 AM
* Role of gender and early childhood in constipation
HeatherAdministrator
09/13/07 11:09 AM
* Changes in Bowel Function: Pregnancy and the Puerperium
HeatherAdministrator
03/01/07 01:39 PM
* Drugs for gastrointestinal disorders in pregnant women.
HeatherAdministrator
05/13/06 03:20 PM
* Functional bowel disorders in patients with pelvic organ prolapse and incontinence
HeatherAdministrator
12/08/05 12:10 PM
* Sex specific alterations in autonomic function among patients with irritable bowel syndrome
HeatherAdministrator
11/12/05 01:16 PM
* Women With Interstitial Cystitis at Risk for Irritable Bowel Syndrome and Depression
HeatherAdministrator
09/22/05 04:39 PM
* Women and Men Perceive Pain Differently
HeatherAdministrator
09/13/05 12:55 PM
* Overlapping Conditions in Women With Irritable Bowel Syndrome
HeatherAdministrator
04/24/05 03:58 PM
* Bowel habit in irritable bowel syndrome in women: Defining an alternator
HeatherAdministrator
04/10/05 06:18 PM
* Recognition and treatment of irritable bowel syndrome among women with chronic pelvic pain
HeatherAdministrator
03/28/05 12:18 PM
* Irritable bowel syndrome, chronic pelvic inflammatory disease and endometriosis
HeatherAdministrator
02/19/05 05:43 PM
* A gene for diarrhoea-predominant IBS in women?
HeatherAdministrator
11/28/04 02:21 PM
* Autonomic Cardiovascular Responses Are Impaired in Women With Irritable Bowel Syndrome
HeatherAdministrator
09/12/04 03:41 PM
* Abdominal Bloating: Relation to Rectal Hypersensitivity and Menstrual Cycle
HeatherAdministrator
06/27/04 01:55 PM
* Catching Colon Cancer in Women Can Be Tough
HeatherAdministrator
04/13/04 03:32 PM
* Women More Sensitive to Pain Than Men
HeatherAdministrator
04/13/04 03:31 PM
* Gender Differences In Brain Response To IBS Pain
HeatherAdministrator
11/18/03 03:32 PM
* After Menopause, IBS Lessens in Women
HeatherAdministrator
11/04/03 03:34 PM
* Is hormone replacement therapy associated with an increased risk of irritable bowel syndrome?
HeatherAdministrator
07/25/03 11:43 AM
* Sleep disturbance influences gastrointestinal symptoms in women with irritable bowel syndrome.
HeatherAdministrator
07/18/03 01:00 PM
* Symptoms across the menstrual cycle in women with irritable bowel syndrome.
HeatherAdministrator
07/18/03 12:58 PM
* Does a physically active lifestyle improve symptoms in women with irritable bowel syndrome?
HeatherAdministrator
07/18/03 12:54 PM
* Relation between hysterectomy and the irritable bowel
HeatherAdministrator
07/18/03 11:48 AM
* Diagnosis and management of IBS, constipation, and diarrhea in pregnancy.
HeatherAdministrator
07/18/03 11:47 AM
* Physician perception of IBS management in women and men.
HeatherAdministrator
07/15/03 06:38 PM
* Gender issues in the management of IBD and IBS
HeatherAdministrator
07/15/03 06:11 PM
* Gender differences in gut transit
HeatherAdministrator
07/15/03 06:07 PM
* Bowel dysfunction in postmenopausal women.
HeatherAdministrator
07/15/03 06:04 PM
* Irritable Bowel Syndrome Worse During Periods
HeatherAdministrator
07/14/03 03:25 PM
* Sex-related differences in IBS patients: Central processing of visceral stimuli
HeatherAdministrator
07/14/03 02:40 PM

Extra information
0 registered and 19 anonymous users are browsing this forum.

Moderator:  Heather 



Permissions
      You cannot post until you login
      You cannot reply until you login
      HTML is enabled
      UBBCode is enabled

Thread views: 178217

Jump to

| Privacy statement Help for IBS Home

*
UBB.threads™ 6.2


McAfee SECURE sites help keep you safe from identity theft, credit card fraud, spyware, spam, viruses and online scams

HelpForIBS.com BBB Business Review