All Boards >> Irritable Bowel Syndrome Research Library

View all threads Posts     Flat     Threaded

Diet May Influence Relapse in Ulcerative Colitis
      10/24/04 07:50 PM
HeatherAdministrator

Reged: 12/09/02
Posts: 7799
Loc: Seattle, WA

Diet May Influence Relapse in Ulcerative Colitis


Laurie Barclay, MD


Sept. 20, 2004 — Potentially modifiable dietary factors, such as high meat or alcoholic beverage intake, may increase the likelihood of relapse for patients with ulcerative colitis (UC), according to the results of a prospective cohort study published in the September issue of Gut.

"The causes of relapses of UC are unknown," write Sarah L. Jowett, MRCP, from the University of Newcastle upon Tyne, U.K., and colleagues. "Dietary factors have been implicated in the pathogenesis of UC."

To determine the effect of customary diet on likelihood of relapse, 191 patients in remission were recruited from two district general hospitals and followed for one year. Relapse was defined using a validated disease activity index; a food frequency questionnaire determined nutrient intake; and multivariate logistic regression, controlling for nondietary factors, determined adjusted odds ratios for relapse.

Of the 191 patients, 96% completed the study, and 52% relapsed. Compared with the lowest tertile of meat consumption, the highest tertile was associated with triple the risk of relapse (odds ratio [OR], 3.2; 95% confidence interval [CI], 1.3 - 7.8. Intake of red and processed meat was an even greater risk factor (OR, 5.19; 95% CI, 2.1 - 12.9. The top tertile of intake for protein (OR, 3.00; 95% CI, 1.25 - 7.19) and alcohol (OR, 2.71; 95% CI, 1.1 - 6.67) also increased the likelihood of relapse, as did high intake of sulfur (OR, 2.76; 95% CI, 1.19 - 6.4) or sulphate (OR, 2.6 (95% CI, 1.08 - 6.3).

Contrary to commonly held beliefs, increased intake of milk or dairy products did not increase risk of relapse, and increased intake of dietary fiber did not appear to protect against relapse.

Study limitations include potential criticisms of the dietary assessment tool; assessment of habitual diet at only one time point for each individual; failure to perform sigmoidoscopy or analysis of stool samples; and incomplete data for sulfur and sulphate content of the diet.

"Potentially modifiable dietary factors, such as a high meat or alcoholic beverage intake, have been identified that are associated with an increased likelihood of relapse for UC patients," the authors write. "Further studies are needed to determine if it is the sulphur compounds within these foods that mediates the likelihood of relapse and if reducing their intake would reduce relapse frequency."

Northumbria Healthcare Trust funded Dr. Jowett.

In an accompanying commentary, Herbert Tilg, from University Hospital Innsbruck in Austria, and Arthur Kaser, from Brigham and Women's Hospital and Harvard Medical School in Boston, Massachusetts, note that the role of dietary factors in UC relapse may be mediated by hydrogen sulfide production.

"This provocative and clinically important report by Jowett et al reopens the topic of diet and relapsing UC," Drs. Tilg and Kaser write. "The findings are well taken and may offer a new perspective for potential intervention by practical lifestyle modifications, and as such are eagerly awaited by our patients. Despite this excitement, interventional studies are now needed, setting the scene for specific dietary recommendations and for further defining the role of sulphur/sulphate which may even lead to novel therapies."

Gut. 2004;53:1399-1401, 1479-1484

Reviewed by Michael W. Smith, MD

http://www.medscape.com/viewarticle/489613?src=mp

--------------------
Heather is the Administrator of the IBS Message Boards. She is the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

Print     Remind Me     Notify Moderator    

Entire thread
* Inflammatory Bowel Disease
HeatherAdministrator
07/14/03 01:51 PM
* Why cannabis relieves IBD symptoms
HeatherAdministrator
08/22/18 02:39 PM
* Dietary fiber associated with reduced Crohn's disease flares
HeatherAdministrator
01/27/16 02:58 PM
* Probiotics not superior for maintaining ulcerative colitis remission
HeatherAdministrator
12/29/15 10:12 AM
* Fecal transplant induces remission in active ulcerative colitis
HeatherAdministrator
07/16/15 04:39 PM
* 7 recent developments in Crohn's disease
HeatherAdministrator
04/02/15 03:16 PM
* Hormonal contraception improved menstrual-related IBD symptoms
HeatherAdministrator
09/15/14 12:43 PM
* Fecal lactoferrin differentiated IBD from IBS
HeatherAdministrator
07/29/14 01:50 PM
* Vitamin D and Cancer Risk in IBD
HeatherAdministrator
07/15/14 02:53 PM
* Self-assessment scale developed for patients with IBD-fatigue
HeatherAdministrator
06/17/14 10:44 AM
* Stool test distinguishes between IBD and IBS
HeatherAdministrator
04/07/14 01:40 PM
* Breathing exercises, meditation improved inflammatory markers, quality of life in IBD patients
HeatherAdministrator
10/23/13 04:20 PM
* Inflammatory Bowel Disease: Heat Waves Linked to Flares
HeatherAdministrator
08/16/13 12:58 PM
* Dietary changes may reduce effects of IBD
HeatherAdministrator
06/27/13 05:43 PM
* Genetic Clues May Help Unravel Cause of Crohn's
HeatherAdministrator
11/02/12 12:59 PM
* Inflammatory bowel, ulcerative colitis linked to intestinal fungi
HeatherAdministrator
06/15/12 01:23 PM
* Smoking makes Crohn's disease worse
HeatherAdministrator
05/09/12 01:33 PM
* Kids With Crohn’s Disease, Colitis Often Struggle at School
HeatherAdministrator
04/23/12 01:22 PM
* As Nations Develop, So May Bowel Disease
HeatherAdministrator
01/09/12 12:01 PM
* Loneliness Triggers Inflammatory Illnesses
HeatherAdministrator
02/10/11 10:05 AM
* Infants' antibiotic use tied to IBD risk
HeatherAdministrator
11/03/10 01:42 PM
* Olive Oil May Protect Against Ulcerative Colitis
HeatherAdministrator
05/05/10 10:32 AM
* Accutane may cause ulcerative colitis
HeatherAdministrator
04/09/10 01:38 PM
* Red meat may raise odds for ulcerative colitis, but oily fish could be protective
HeatherAdministrator
03/11/10 01:22 PM
* Inflammatory Bowel Disease and Irritable Bowel Syndrome: Separate or Unified?
HeatherAdministrator
01/05/10 12:03 PM
* Novel Compound Targets Mucosal Healing in Crohn's
HeatherAdministrator
05/29/06 02:19 PM
* Viagra May Help Crohn's Disease
HeatherAdministrator
03/04/06 12:50 PM
* Carbon Monoxide Eases Ulcerative Colitis
HeatherAdministrator
01/18/06 04:12 PM
* Colonoscopic Surveillance in Inflammatory Bowel Disease
HeatherAdministrator
10/11/05 01:33 PM
* Oral Contraceptives and HRT a Risk Factor for Inflammatory Bowel Disease
HeatherAdministrator
09/13/05 01:22 PM
* Cannabinoids Show Promise for Inflammatory Bowel Disease
HeatherAdministrator
09/01/05 11:23 AM
* Differentiation of Inflammatory Bowel Disease and Irritable Bowel Syndrome
HeatherAdministrator
09/01/05 11:13 AM
* The Clinical Epidemiology of Inflammatory Bowel Disease
HeatherAdministrator
08/22/05 04:45 PM
* IBD Patients May Benefit From Folic Acid Supplementation
HeatherAdministrator
05/22/05 07:02 PM
* Fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis
HeatherAdministrator
04/24/05 03:33 PM
* Biotic Therapy Cuts Inflammation in Ulcerative Colitis
HeatherAdministrator
02/19/05 05:59 PM
* Calming Crohn's Disease with Fish Oil and Antioxidants
HeatherAdministrator
01/07/05 04:55 PM
* Probiotics Prove Just As Effective As a Popular Prescription Drug for Ulcerative Colitis
HeatherAdministrator
12/20/04 01:37 PM
* Increased Incidence of Inflammatory Bowel Disease: The Price of the Decline of Infectious Burden?
HeatherAdministrator
11/28/04 02:58 PM
* Diet May Influence Relapse in Ulcerative Colitis
HeatherAdministrator
10/24/04 07:50 PM
* Parasite Therapy for Crohn's and Colitis?
HeatherAdministrator
08/08/04 03:00 PM
* Pipeline Treatments, Novel Procedures Offer New Options for GI Diseases
HeatherAdministrator
06/04/04 06:41 PM
* Faulty Gene for Crohn's Disease Found
HeatherAdministrator
04/13/04 03:19 PM
* Data links Crohn's disease and antibiotics
HeatherAdministrator
02/24/04 02:07 PM
* Elan Reports Successful Results of Antegren Trial for Crohn's Disease
HeatherAdministrator
02/10/04 01:30 PM
* 5-ASA Therapy for Inflammatory Bowel Disease No Bar to Colon Cancer
HeatherAdministrator
02/10/04 01:29 PM
* Once-Daily Probiotic Treatment Maintains Remission in Ulcerative Colitis patients with Pouchitis
HeatherAdministrator
01/26/04 03:33 PM
* Bone Disease and Intestinal Problems May Share a Common Cause
HeatherAdministrator
01/07/04 11:47 AM
* Increased Anal Resting Pressure and Rectal Sensitivity in Crohn's Disease
HeatherAdministrator
12/16/03 11:59 AM
* Environmental Factors May Play a Role in the Pathogenesis of IBD
HeatherAdministrator
12/01/03 05:56 PM
* Colonoscopy Prep
HeatherAdministrator
10/17/03 12:05 PM
* Detection of Pulmonary Involvement in Inflammatory Bowel Disease
HeatherAdministrator
09/30/03 01:20 PM
* Indeterminate Colitis
HeatherAdministrator
09/16/03 03:33 PM
* Familial Occurrence of Inflammatory Bowel Disease in Celiac Disease
HeatherAdministrator
09/16/03 03:30 PM
* Bacteria in Milk Linked to Crohn's Disease and Possibly IBS
HeatherAdministrator
08/12/03 11:55 AM
* Inflammatory Bowel Disease During Pregnancy.
HeatherAdministrator
07/15/03 06:20 PM
* A study of the menopause, smoking, and contraception in women with Crohn's disease.
HeatherAdministrator
07/15/03 06:05 PM
* Hormone replacement therapy prevents bone loss in patients with IBD
HeatherAdministrator
07/15/03 06:02 PM
* Chemo Drug Improves Crohn's Symptoms
HeatherAdministrator
07/14/03 04:09 PM

Extra information
0 registered and 34 anonymous users are browsing this forum.

Moderator:  Heather 



Permissions
      You cannot post until you login
      You cannot reply until you login
      HTML is enabled
      UBBCode is enabled

Thread views: 336634

Jump to

| Privacy statement Help for IBS Home

*
UBB.threads™ 6.2


HelpForIBS.com BBB Business Review