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Autonomic Cardiovascular Responses Are Impaired in Women With Irritable Bowel Syndrome       09/12/04 03:41 PM Edit Reply Quote Heather Reged: 12/09/02 Posts: 7799 Loc: Seattle, WA Autonomic Cardiovascular Responses Are Impaired in Women With Irritable Bowel Syndrome. Journal of Clinical Gastroenterology. 38(8):658-663, September 2004. Waring, W Stephen BMedSci, MB MRCP(UK) *; Chui, Michelle BSc MB ChB +; Japp, Alan BSc, MB ChB +; Nicol, E Fiona BSc, MB FRCP ++; Ford, Mike J MD FRCP + Abstract: Goals: This study characterizes cardiovascular autonomic function in women with irritable bowel syndrome (IBS), using standardized techniques. Background: Autonomic dysfunction is believed to contribute to abnormal gastrointestinal motility and visceral hypersensitivity in IBS. There is mounting evidence of generalized impairment of autonomic activity in patients with IBS. Study: Thirty women aged 39 years (95% C.I. 25-53 years) diagnosed with IBS, and 30 age-matched healthy women were studied. The ratio of low frequency to high frequency heart rate variability domains (LF:HF ratio) was used to represent cardiac sympathovagal activity, and orthostatic testing and sustained isometric handgrip exercise were used as sympathetic stimuli. Parasympathetic activity was represented by the expiratory to inspiratory R-R interval (E:I) ratio during deep breathing at 6 minutes-1. Results: LF:HF responses to handgrip exercise (316%, C.I. 134% to 498% vs. 107%, C.I. 15% to 153%; P < 0.05) and orthostatic testing (648%, C.I. 520% to 904% vs. 330%, C.I. 140% to 520%; P < 0.05) were higher in IBS patients than controls, and the E:I ratio was significantly lower (1.47, C.I. 1.33-1.61 vs. 1.20, C.I. 1.14-1.26; P < 0.01). Conclusions: Autonomic cardiovascular function is impaired in IBS, manifest as attenuated cardio-vagal tone, and relative sympathetic excess during stimulated conditions. (C) 2004 Lippincott Williams & Wilkins, Inc. http://www.mdlinx.com/GILinx/thearts.cfm?artid=1041738&specid=13&ok=yes -------------------- Heather is the Administrator of the IBS Message Boards. She is the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook! Print     Remind Me     Notify Moderator

Entire thread Gender / Hormones Heather 07/14/03 01:57 PM Pain management in women is often overlooked and ineffective Heather 02/16/15 04:42 PM Women, Hormones and IBS Heather 03/11/14 02:09 PM Fennel is an effective herbal drug for menstrual pain Heather 08/27/13 11:29 AM Constipation and Risk of Cardiovascular Disease among Postmenopausal Women Heather 08/03/11 03:58 PM Differences in Gastrointestinal Symptoms According to Gender in Rome II Positive IBS and Dyspepsia Heather 03/11/10 01:51 PM Gender-related differences in prepulse inhibition of startle in irritable bowel syndrome Heather 03/11/10 01:48 PM No evidence of sex differences in heritability of irritable bowel syndrome Heather 03/31/08 11:36 AM Acupuncture for the treatment of pain from a gender perspective. Heather 03/31/08 11:27 AM The menstrual cycle and its effect on inflammatory bowel disease and irritable bowel syndrome Heather 11/07/07 02:35 PM Irritable Bowel Syndrome Is More Common in Women Regardless of the Menstrual Phase Heather 11/07/07 02:31 PM Pelvic floor dysfunction and IBS in patients with interstitial cystitis. Heather 10/10/07 12:33 PM Women with IBS have abnormal pain modulation Heather 10/10/07 12:01 PM Anxiety or Depression with IBS Affects More Women Than Men Heather 09/24/07 11:31 AM Colonoscopies more difficult and painful for women and people with IBS Heather 09/24/07 11:22 AM Role of gender and early childhood in constipation Heather 09/13/07 11:09 AM Changes in Bowel Function: Pregnancy and the Puerperium Heather 03/01/07 01:39 PM Drugs for gastrointestinal disorders in pregnant women. Heather 05/13/06 03:20 PM Functional bowel disorders in patients with pelvic organ prolapse and incontinence Heather 12/08/05 12:10 PM Sex specific alterations in autonomic function among patients with irritable bowel syndrome Heather 11/12/05 01:16 PM Women With Interstitial Cystitis at Risk for Irritable Bowel Syndrome and Depression Heather 09/22/05 04:39 PM Women and Men Perceive Pain Differently Heather 09/13/05 12:55 PM Overlapping Conditions in Women With Irritable Bowel Syndrome Heather 04/24/05 03:58 PM Bowel habit in irritable bowel syndrome in women: Defining an alternator Heather 04/10/05 06:18 PM Recognition and treatment of irritable bowel syndrome among women with chronic pelvic pain Heather 03/28/05 12:18 PM Irritable bowel syndrome, chronic pelvic inflammatory disease and endometriosis Heather 02/19/05 05:43 PM A gene for diarrhoea-predominant IBS in women? Heather 11/28/04 02:21 PM Autonomic Cardiovascular Responses Are Impaired in Women With Irritable Bowel Syndrome Heather 09/12/04 03:41 PM Abdominal Bloating: Relation to Rectal Hypersensitivity and Menstrual Cycle Heather 06/27/04 01:55 PM Catching Colon Cancer in Women Can Be Tough Heather 04/13/04 03:32 PM Women More Sensitive to Pain Than Men Heather 04/13/04 03:31 PM Gender Differences In Brain Response To IBS Pain Heather 11/18/03 03:32 PM After Menopause, IBS Lessens in Women Heather 11/04/03 03:34 PM Is hormone replacement therapy associated with an increased risk of irritable bowel syndrome? Heather 07/25/03 11:43 AM Sleep disturbance influences gastrointestinal symptoms in women with irritable bowel syndrome. Heather 07/18/03 01:00 PM Symptoms across the menstrual cycle in women with irritable bowel syndrome. Heather 07/18/03 12:58 PM Does a physically active lifestyle improve symptoms in women with irritable bowel syndrome? Heather 07/18/03 12:54 PM Relation between hysterectomy and the irritable bowel Heather 07/18/03 11:48 AM Diagnosis and management of IBS, constipation, and diarrhea in pregnancy. Heather 07/18/03 11:47 AM Physician perception of IBS management in women and men. Heather 07/15/03 06:38 PM Gender issues in the management of IBD and IBS Heather 07/15/03 06:11 PM Gender differences in gut transit Heather 07/15/03 06:07 PM Bowel dysfunction in postmenopausal women. Heather 07/15/03 06:04 PM Irritable Bowel Syndrome Worse During Periods Heather 07/14/03 03:25 PM Sex-related differences in IBS patients: Central processing of visceral stimuli Heather 07/14/03 02:40 PM

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