Zoloft has D as a side effect. I finally weaned myself off of it this week to see if my problems improve. The years that I have been on either Paxil or Zoloft have been the years my IBS was at its worst. Now, the question is when it comes to the meds/IBS...is it the chicken or the egg? lol I LOVE zoloft! It keeps me on an even keel emotionally, but I'm trying some time off of it to see what happens with my IBS. If it doesn't work, maybe I'll try lexapro. Lots of people seem to have had good luck with that one. The pharmacist said that one has the least likelihood of the SSRIs to cause problems for my IBS. So....we'll see what happens. Check out the zoloft with both your docs and see what they think. Maybe that one isn't the best choice for you if you are ibs/d. Just a thought!