Oh sure, it's very possible to lose weight with IBS!  Have you read Shell's story? (she's the moderator of this board, the story is in a sticky on the top of the list of posts) ...She's lost an incredible amount of weight, and she has IBS. Really, your thyroid will probably pose more of a difficulty than anything, and I'm afraid I can't be of much help there 
If you're really having troubles with digesting vitamins, some people find that asking their doc to give them prenatal vitamins (whether they're pregnant or not) can be helpful - prenatal vitamins are made to be really gentle on the stomach. In general though, the one thing you want to watch for in vitamins is articifical sweeteners, which are an IBS trigger.
As for breathing exercises... hmmm I don't know of any specific ones, but I do find that deep, focussed breathing can really be key to getting me through the pain of an attack. This page on yoga breathing has some good articles and exercises that you might find helpful - in general, yoga and IBS go very well together.
HTH!
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