I recently starting taking Effexor XR (37.5 mg). I have been on this about 1 month. I never tried any kind of medication before this and was so sick I was willing to trying anything. I'm also IBS-D and this has helped me alot (I will still get an attack if I cheat on my diet though). Also, it does seem to make me feel a little calmer, I was always a nervous anxious panicky person and I don't seem to be as bad on the meds.
When my dr. told me he was going to give me medication I told him I didn't want one with the side effect of of weight gain and since being on the Effexor I have lost about 7-8 lbs (that always makes me happy).