Irritable Bowel Syndrome Message Boards | Re: treatment for high methane levels?

It sounds like you have done a fair amount of research on methane production and C. As you have noted the degree of C can be directly correlated with the amount of methane produced. If you have access to a University library you might find this recent article Methane and the Gastrointestinal Tract of interest. Unfortunately the link is just to the abstract. Note that Dr. Pimental is one of the authors. He is an advocate of SIBO as a possible cause of IBS and the use of Xifaxan for non-constipating IBS which has not yet been approved by the FDA because of the controversial results. You may have notice the recent posting on the new clinical trial that is about to begin. In the review the authors indicate that very small clinical trials have been done using gentamycin, cephazolin and neomycin. However, the authors acknowledge antibiotic therapy is non-specific and eradicates other gut organisms along with the methanogenic ones which may produce other problems.

There is currently a clinical trial underway comparing Neomycin to Rifaximin Plus Neomycin in the Treatment of Methane Positive Subjects With Constipation Predominant Irritable Bowel Syndrome (C-IBS). I have not seen any results have been published.

Not sure if probiotics have been shown to have any effect on SIBO.

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