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For example, a 4-carbon polyol, is well-absorbed in the jejunum but mannitol, a 6-carbon polyol, is not.[31] Secondly, there is variation of pore size along the small intestine with larger pores proximally. Thus, erythritol is less well-absorbed in the ileum.[32] The rapidity of transit through the jejunum will therefore influence the degree of absorption. Finally, pore size is affected by mucosal disease; pore size reduces in celiac disease where erythritol is poorly absorbed.

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