In my (just like all of yours too I'm sure) constant search for relief, if not resolution from my IBS, I've come across this website and thought you all may want to take a look too... www.cfsn.com/ibs.html Of particular interest to me is the Leaky Gut and the role of our Liver and Glutathione in our digestive process. This is because I recently had a frustrating experience with using Cholestyramine where I enjoyed some temporary relief with no explanation available for why it did not last. The cholestyramine is supposed to bind bile acids and decrease their diarrheal effect. While this is associated with your gallbladder (Habba Syndrome), your liver and pancreas also produce bile acids that aid in digestion so I can't help but wonder and feel that there must be some connection here? Fueling this for me is that I know I get a constipating affect from taking protein (for weight training purposes) and it turns out that the 3 Amino acids in Glutathione (Cysteine, Glutamine and Glycine) are all in my protein. And I even came across this post from a fellow IBS-D sufferer http://www.ibsgroup.org/forums/index.php?showtopic=112513 and will be looking for a nutraceutical (as she calls it) to try. If anyone out there has dealt with this already I would love to hear from you and any thoughts about some of the other supplements mentioned.