Re: Post-Infectious IBS
04/15/09 08:31 AM
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Syl
Reged: 03/13/05
Posts: 5499
Loc: SK, CANADA
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You may find the first reference below about post-infectious IBS of interest. Essentially it says post-infective IBS (PI-IBS)develops in 3–30% of individuals with bacterial gastroenteritis. About 65% of individuals with PI-IBS recover within 3-5 years.
Tricyclic antidepressants in low doses appear effective for irritable bowel syndrome and for a variety of other painful conditions, including migraine, neuropathic pain, pain due to cancer, etc. The underlying mechanism of the benefit is unknown, but it could be due to a reduction in the sensitivity of peripheral nerves or to alterations in the brain. The second reference below has some discussion about the use of low dose antidepressants for controlling IBS pain in section 7.5.3 (page 1786).
Reference
Spiller, R Post Infectious Irritable Bowel Syndrome. The UNC Center for Functional GI & Motility Disorders
Spiller, R., Q. Aziz, F. Creed, et.al, 2007: Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut, 56, 1770-1798.
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