I have IBS (mostly C) and I have found Mg Oxide to be very helpful as well. However I only take 300-600 mg before bed. I worry too about long-term effects but for now it is helping me regain some sanity in life.
What happens if you try a lower dose? Might be worth a try. 1600 mg seems like a lot to me.
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Re: Magnesium Odixe- it works for IBS-C, but too much?
