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Re: But
      03/26/08 08:54 AM
Syl

Reged: 03/13/05
Posts: 5499
Loc: SK, CANADA

I know of only three probiotics that have been proven through clinical trials to be effective for IBS: VSL#3, lactobacillus plantarum and Bifidobacterium infantis 35624 (Align). A recent review of probiotics in clinical practice (see first reference below) indicates that only certain species of lactobacillus and bifidobacterium have any efficacy for IBS.

VSL#3 and lactobacillus plantarum were small trials showing limited efficacy compared to placebo. There have been three Bifidobacterium infantis 35624 trial that were much larger and the efficacy was high for all IBS symptoms in IBS-C and IBS-D. The mechanism by which the later probiotic works in IBD to reduce localized bowel inflammation is better understood (see second reference below) and hypothesized to be similar in IBS. VSL#3 contains a variety of organisms including lactobacillus plantarum and Bifidobacterium infantis (perhaps different strain than 35624) and this may be part of the reason for its partial efficacy in IBS.

It is not the number of organisms in a probiotic that determines it's effectiveness. It is the type, species and amount of individual organisms that determine the efficacy. While there may be other probiotics that are effective for IBS they have not been clinically proven. I won't rely on self-reports from one or even few individuals to judge the efficacy of any probiotic on IBS.

I hope this helps

Reference
Zuccotti, G. V., et. al., 2008: Probiotics in clinical practice: An overview. Journal of International Medical Research, 36, 1A-53A.

Shiba, T., et. al., 2003: The Suppressive Effect of Bifidobacteria on Bacteroides vulgatus, a Putative Pathogenic Microbe in Inflammatory Bowel Disease. Microbiology and Immunology, 47, 371-378

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Entire thread
* probiotics success - any long term information?
Claudie
03/23/08 05:53 AM
* Re: probiotics success - any long term information?
Islandsguy123
04/20/13 06:08 AM
* udo's website
sun
04/23/08 09:40 PM
* Re: probiotics success - any long term information?
CJIBSDG
04/18/08 05:02 PM
* Re: probiotics success - any long term information?
Kimba728
05/21/13 01:36 PM
* Re: probiotics success - any long term information?
Kimba728
05/15/13 06:08 PM
* Re: probiotics success - any long term information?
Joannelcoq
03/29/08 06:54 AM
* VSL#3
Little Minnie
03/24/08 04:48 PM
* And Align (Bifidobacterium infantis 35624 )
Syl
03/24/08 06:29 PM
* Align contains casein -nt
Little Minnie
03/28/08 05:33 PM
* And ...
Syl
03/28/08 06:02 PM
* but it wouldn't last
Little Minnie
03/31/08 05:42 PM
* Clinical trials are not a fad
Syl
04/01/08 07:26 AM
* try to be less annoying
Little Minnie
04/01/08 04:07 PM
* Re: try to be less annoying
Zara
04/02/08 05:05 AM
* My apologies - I thought we were having a discussion -nt-
Syl
04/01/08 04:48 PM
* Thank you Syl
Barbara50
04/02/08 05:19 AM
* Re: Thank you Syl
Angel in Pain
04/18/08 10:14 PM
* Re: Thank you Syl
Syl
04/23/08 08:11 PM
* Re: Thank you Syl
mradams1
04/08/13 08:03 AM
* Re: Thank you Syl
Syl
04/08/13 08:11 AM
* Re: Thank you Syl
mradams1
04/10/13 01:45 AM
* Re: Thank you Syl
Syl
04/10/13 04:29 AM
* Re: Thank you Syl
mradams1
04/22/13 02:22 AM
* Re: Thank you Syl
Syl
04/22/13 04:21 AM
* Re: Thank you Syl
mradams1
05/14/13 03:57 AM
* Re: Thank you Syl
mradams1
04/22/13 05:03 AM
* Re: Thank you Syl

04/02/08 06:09 AM
* Re: Thank you Syl
lalala
04/02/08 06:27 AM
* But
Jordy
03/26/08 07:49 AM
* trials
Little Minnie
03/26/08 05:31 PM
* Re: trials
Syl
03/26/08 07:15 PM
* Re: trials
Little Minnie
03/27/08 05:46 PM
* Re: trials
Syl
03/28/08 05:22 AM
* Re: trials
Jordy
03/28/08 05:50 AM
* Re: trials
Syl
03/28/08 06:22 AM
* Re: trials
Jordy
03/28/08 07:11 AM
* Re: trials
Syl
03/28/08 07:24 AM
* different name for Bifidobacterium infantis 35624
Claudie
03/28/08 06:32 PM
* Claudie
Jordy
03/30/08 01:11 PM
* It is different
Syl
03/29/08 05:45 AM
* Re: But
Syl
03/26/08 08:54 AM
* Re: But
Jordy
03/26/08 09:49 AM
* Re: But
Syl
03/26/08 10:22 AM
* Re: But
Jordy
03/26/08 11:40 AM
* Re: But

03/26/08 10:35 AM
* Re: But
Syl
03/26/08 01:12 PM
* Re: But
Destydan
04/06/13 11:10 PM
* Re: But
Robbie0166
04/25/08 09:28 AM
* Re: But
Erilyn
03/26/08 01:43 PM
* Re: But
Syl
03/26/08 02:28 PM
* Re: And Align (Bifidobacterium infantis 35624 )
Claudie
03/25/08 08:24 PM
* Re: And Align (Bifidobacterium infantis 35624 )
Jordy
03/26/08 07:45 AM
* Re: And Align (Bifidobacterium infantis 35624 )
Claudie
03/26/08 08:25 PM
* Abstract of orginal results
Syl
03/27/08 05:59 AM
* Re: Abstract of orginal results

03/31/08 01:37 PM
* Re: Abstract of original results
Syl
03/31/08 02:45 PM
* Re: Abstract of original results

04/01/08 05:48 AM
* Re: probiotics success - any long term information?
Jordy
03/23/08 10:16 AM
* Re: probiotics success - any long term information?
Claudie
03/23/08 08:54 PM
* Re: probiotics success - any long term information?
Syl
03/24/08 06:13 AM
* Re: probiotics success - any long term information?
Syl
03/23/08 08:22 AM

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