I will check the research literature and see what I can find.
Duspatal ( Mebeverine ) has been used for IBS for nearly 50 years.
Dicetel ( pinaverium ) is a newer drug that I believe is still not available in the US but is available in Europe and Canada. When muscle cells contract as a result of a stimulus there is a rapid influx of intracellular calcium (Ca+) into the muscle cells. This drug reduces the rate of Ca+ influx which in turn reduces the intensity of the muscle contracts. It is particularly targeted at intestinal smooth muscle cells.
Calcium is used in the body for a variety of things including things like bone structure and membrane depolarization. The amount of the total calcium pool in the body that would be affected by this drug would be quite small.
PS - I have tried a number of antispasmodics and other IBS drugs over the years. I have not found one that had an impact on my GI spasms
-------------------- STABLE: ♂, IBS-D 50+ years - Science of IBS
Posts
Re: Research question for Syl and other interested people
