Irritable Bowel Syndrome Message Boards | Re: prostaglandin and IBS

This article says that resveratrol (found in red wine) prevents cell death in a specific kind of cancer cell - human erythroleukemia K562 cells. These cells were grown in a liquid media culture in the laboratory (i.e. the cells did not reside in the human body). The resveratrol and other agents that were being tested were dissolved in methanol and then added to the growth media. Resveratrol reduced the elevation of prostaglandin E2 induced by hydrogen peroxide in these cells. Hydrogen peroxide plays a role in programmed cell death (apoptosis). Resveratrol was shown to inhibit the cyclooxygenase activity of the prostaglandin H synthase enzyme. This enzyme is involved the biosynthesis of the prostaglandins.

In summary, the article shows that resveratrol reduces prostaglandins in a very specific cell under very specific conditions. The authors of the article conclude the findings "may give a biochemical background to the effect of this compound [resveratrol] in coronary heart disease and cancer prevention." The results cannot be generalized to say that drinking red wine will decrease prostaglandin E2 production.

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