I've been reading the boards for a while. Long time sufferer ( 24 years- I'm 37 years old) of IBS-D. The only drug I was ever offered by my gastro was Dicyclomine a few years ago. You name the test-I've had it. You name the embarassing situation-I've been in it! One day last May, my gastro was busy so I saw his PA. OH MY GOD! She was a life-saver. She prescribed Glycopyrrolate (AKA Robinul Forte) and I have a life again. At first it made me sleepy (especially if I had a beer or wine with it on a Friday night)so I stopped taking it. However, in July I was having D everyday, non-stop, everything made me sick. It ruined yet ANOTHER vacation. 2 hours in Taco Bell bathroom on I5...not fun! ( and I didn't eat there!) At the end of August with school starting soon ( I teach) I grabbed the bottle of pills, cut out coffee, tea, meat, etc. Within 2 days, I was feeling "normal." I have had only 2 "episodes" since the end of August '06 and they were predictable ones I saw coming (bad food/drink choices.) I can now have ANYTHING I want to eat ( EXCEPT really creamy sauces and super spicy) and I can now have a small coffee each morning.
The only negative is that I have gained about 5 pounds since this is the first time since I was 13 that I can EAT!
Please if you haven't tried it, ask your docs about it. I swear, It gave me my life back. No one understands that statement who has not suffered with this illness. 24 years was long enough. I hope someone can be helped by this info.
Robbie 
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Go my life back after 24 yrs- Glycopyrrolate ( Robinul Forte)
