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Hi Miso. I have done a bit of research. Here is what I have learned.

Glutamine, a 5-carbon non-essential amino acid, is the most abundant free amino acid in the body. It is consumed by actively growing cells such as the lining of the gut and other viseral organs. Skeletal muscle synthesizes and stores glutamine. Almost all of glutamine in the blood is derived from the intracellular glutamine pool in skeletal muscle.

The intestine uses about 1/3 of the total glutamine in the body. It is absorbed into the viseral organs and it is rapidly metabolised within the intestine. About 25% of the glutamine in blood is removed each time it passes through the small intestine.

Patients maintained on TPN become depleted in glutamine. However, there is a lack of evidence from clinical trials demonstrating that supplementation with glutamine has specific clinical advantages.

References
Coster, J., R. McCauley, and J. Hall, 2004: Glutamine: metabolism and application in nutrition support. Asia Pacific Journal of Clinical Nutrition, 13, 25-31.

Griffiths, R. D. and F. Andresw, 2001: Glutamine: a life threatening deficiency in the critically ill? Intensive Care Medicine, 27, 12-15

Rhoads, M., 2001: Glutamine Metabolism: Nutritional and Clinical Significance. Journal of Nutrition, 131, 2532S�2534S.

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