I have been on Luvox for 10 years or so for my anxiety and OCD. It, as many have said, gave me my life back. I could actually function as a human being, work, etc. although it took me some time to adjust to being sleepy from it. I am still not the perkiest of people, but I do well enough to have a good life. It never seemed to make my IBS better or worse, but the interesting thing is I recently went on the smallest doseage of seroquel in addition to my other drugs (to help me sleep) and I found it helped my D considerably. I now end up on the C side of things and have to eat more IS foods- which is fine by me!