Primal Defense keeps me regular but once in a while I'll need to take a fibre supplement. Right now I'm taking 4-6 a day, but when I started, I worked my way up to 12 tablets a day and kept that dosage constant for about a month, then I decreased it to 8, then to 6. I've only been taking it for about 4 months. Eventually I will try to get down to only 3 a day, and I'll see what my symptoms are. If they start to get worse, I'll increase the dosage.