When I first was diagnosed with IBS, I WAS on anti-depressants. Once I learned to control it with my diet and soluble fiber supplements, I went off of them. Everyone is different. What I'm doing now is working great for me, so I haven't needed to try anything else. I did try peppermint caps, but then I read since I also have GERDS I shouldn't be taking peppermint!?!? It is very much trial and error, unfortunately. I finally found what works for me, but it took awhile. I hope you find what works for you!! This board helped me TREMENDOUSLY though!! I just kept getting more and more information and found what worked for me!