I take my Jarrodopholis EPS with my 5-htp and b-6 with a glass of tap water first thing in the morning. I don't know anything about the hot/cold issue as there is no notation of this on the box. I was taking it in the evening just before supper, but wanted to see if the total empty stomach made a difference. So far, I've noted no huge difference, but decided to add it to my other empty stomach supplements since it was recommeded.
I think my biggest benefit still to date is that my sinuses are SOOOOO much better!! I used to take decongestants like candy and now....NEVER. (well, I did have a small cold last week, but I took antihistamines for the drip - no severe congestion even then) Since I'm pretty stable now on just the one a day, I'm not messing with my dose.