Acacia was the first supplement I added. VERY SLOWLY. Made all the difference to me! I carefully researched this site and many other health food sites and slowly added the following based on my body's needs: (I'm C predominant) calcium/mag supplement, Jarrodophilus EPS, Super Omega 3-6-9. I added them one at a time and gave each one about 2 months for effect before adding another. I tried the enzymes, but stopped because it affected my bc pills. After almost 18 months, I'm nearly stable again as long as I get plenty of sleep and avoid stress.