SInce I am an IBS-A, I can get constipated easily. It sounds like you have pretty bad D and would be able to take the medication and still be able to go. My D wasn't terrible - probably 2 times a day, so it constipated me pretty quickly. The cramping was awful and the medication really helped with that as well. But like I said, your D is worse than mine so you would probably be able to take a low dose and still be able to go.