Hi Carrieokie, Thanks for your response. My life revolves around IBS-D, panic disorder, major clinical depression, and fibromyalgia. I got a double dip out of the faulty gene pool. That's my main problem with trying anything new. I'm especially stubborn about trying new AD's because Paxil almost did me in and after that I was given Effexor. Ditto. Everytime, I go to the store and look in the pharmacy aisles, I'm always leary because I don't know what I can take that will be okay with the meds I take and my assortment of ailments. Most of the time, I just suffer through whatever I've come down with at the time. I'll buy some SFS tomorrow and then probably wait until I feel really confident before taking one. Thanks, Teresa