Hi, all. I am currently taking 25 MG per day of Paxel CR for depression. It helps with the emotional problems, but it has some lousy side effects. Nearly a constnat, dragging fatigue, always thirsty, and minor constant headache. I've learned to fight these by dramatically increasing how much water I drink, which of course is good for my IBS, too. However, when we've tried other meds, they've not had side effects, but also not treated the depression. The Paxel has increased my appetite and eating, but it hasn't really effected my IBS. My eating habits have done that! I didn't even know there could be a link to AD's and IBS, till seeing this thread. Thanks for the new info!