Hi Steffie... Boy do I feel your pain! So, I had horrible nausea and vomiting for one day/evening and then had D the next day. I let the D go for about a day and a half and then finally gave in and took an immodium, as I was supposed to go out with some friends. It helped the cramping and D a whole lot and I was glad I took it. However, that was on Thursday evening. Today is Monday and I FINALLY just had a BM. And this BM came with horrible cramping and stomach pains on and off all day... But the D was so bad I really needed the relief from the immodium. So, I am for taking it and feeling like getting some sanity back in my life. My Mom is a nurse and always says that if the D really needs to come out, one immodium certainly won't stop it....so that always makes me feel like I'm not stopping the virus. Hope this helps at all...it's so difficult to deal with this when IBS is already in our lives!!! Let me know how you are feeling. The plus of this whole mess is that I ended up losing about 5 lbs and still don't have much of an appetite! lol Alyson