I'm IBS-D. Never took any medication before but my new doc put me on Effexor about 1 1/2 months ago and I am totally amazed at the difference.
I still pretty much eat only safe things with a little cheating here and there but I used to get really bad bouts of D every day. I gave up coffee and take my meds and I feel so much better, none of the gut wrenching pain and running for the bathroom. I'm not saying that I won't get sick if I really cheat badly but before this I wasn't able to eat hardly anything without getting sick.
So for me I have to say I'm glad I tried it and I'm happy I feel better.