Re: biopsy for celiac...
10/13/11 07:58 AM
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Syl
Reged: 03/13/05
Posts: 5499
Loc: SK, CANADA
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Welcome to the board,
The biopsy is the gold standard for celiac disease.
There have been a couple of small clinical trials looking for the possibility that gluten sensitivity exists without having celiac disease. So far no mechanism has been identified and the evidence for its existence is scarce. The medical research is inconclusive at this point. See references below.
On the other hand, there is clinical evidence to show that an indigestible food constituent found in wheat, rye and some vegetables called fructans can cause bloating and gas when fermented in the colon which can exacerbate IBS symptoms. You can read more about it in the first to links in my signature.
Refences
Verdu, E. F., D. Armstrong, and J. A. Murray, 2009, Between Celiac Disease and Irritable Bowel Syndrome: The "No Man's Land" of Gluten Sensitivity : American Journal of Gastroenterology, v. 104, p. 1587-1594.
Biesiekierski, J. R., E. D. Newnham, P. M. Irving, J. S. Barrett, M. Haines, J. D. Doecke, S. J. Shepherd, J. G. Muir, and P. R. Gibson, 2011, Gluten Causes Gastrointestinal Symptoms in Subjects Without Celiac Disease: A Double-Blind Randomized Placebo-Controlled Trial : American Journal of Gastroenterology, v. 106, p. 508-14.
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