There is no indication in the IBS research literature that leaky gut is associated with IBS or that bile or any particular amino acids or proteins affect or exacerbate IBS symptoms.
I cannot remember if you are IBS-C, IBS-D or IBS-A. Please remind me. It is helpful to put it in you signature. What symptoms in particular are you trying to deal with?
-------------------- STABLE: ♂, IBS-D 50+ years - Science of IBS