Jack Wood, PhD
Professor of Physiology and Internal Medicine
Chairman Emeritus, Department of Physiology
The Ohio State University College of Medicine
Dr. Wood was the first to use microelectrodes to record the electrical and synaptic behavior of neurons in the enteric nervous system. He coined the term "brain-in-the-gut" in view of emerging evidence that the enteric nervous system had neurophysiological properties like the brain and spinal cord. In recent years he has focused on signaling interactions between the enteric immune system and the brain-in-the-gut during infectious enteritis and food allergy. In this lecture he shows how the central nervous system, enteric nervous system and intestinal immune system are integrated during physical and emotional stress to produce irritable bowel symptoms of diarrhea and abdominal pain and discomfort.
Neurophysiology of Brain-Gut Interactions During Stress
http://www.conference-cast.com/ibs/Lecture/RIDs/RID_BuildLecture.cfm?LectureID=7
J Neuroimmunol. 2004 Jan;146(1-2):1-12. Related Articles, Links
Critical role of mast cells in inflammatory diseases and the effect of acute stress.
Theoharides TC, Cochrane DE.
Department of Pharmacology and Experimental Therapeutics, Tufts-New England Medical Center, Boston, MA, USA
Mast cells are not only necessary for allergic reactions, but recent findings indicate that they are also involved in a variety of neuroinflammatory diseases, especially those worsened by stress. In these cases, mast cells appear to be activated through their Fc receptors by immunoglobulins other than IgE, as well as by anaphylatoxins, neuropeptides and cytokines to secrete mediators selectively without overt degranulation. These facts can help us better understand a variety of sterile inflammatory conditions, such as multiple sclerosis (MS), migraines, inflammatory arthritis, atopic dermatitis, coronary inflammation, interstitial cystitis and irritable bowel syndrome, in which mast cells are activated without allergic degranulation.
PMID: 14698841
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My website on IBS is www.ibshealth.com
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