I noticed right away it was 'doing something' as my stomach felt rumbly and different, not necessarily in a bad way. The past couple weeks I've had a lot of stress so we'll see now that I'm more relaxed if I'll do better with more IF and fat in my diet. I noticed it has helped me need less Imodium, but looking at cost of Imodium vs Bio-K+ this isn't really enough of a good change to make it worth while. I'm not sure yet if I'll continue using it as a daily probiotic. I know it could take anywhere from 4-6 weeks to really notice a difference so I'll continue for now. I would definetly use BIO-K+ if I had to go through a round of antibiotics or something though.