Enzymes are present in the mouth (through saliva), stomach and small intestines, however they are created (mostly) by the pacreas (the liver and gallbladder also play a large role though in the creation of bile, which is also important to digestion.) Conditions affecting these organs - liike cystic fibrosis, sickle cell anemia, hepatitis etc. - can affect the ability of these organs to produce enzymes and other substances that aid in digestion (like bile).
However, poor digestion or IBS-symptoms are NOT good reasons to think you might have one of these conditions!  It seems like kind of a stretch if you have no other signs that these organs might be causing problems. People's enzyme production naturally reduces with age. It's also naturally changed by eating habits - for example, if we never eat beans our bodies don't produce or stop producing much of the enzyme to digest beans, so we may have to help it out with Beano for a while! Some people are naturally without some enzymes - like people who are lactose intollerant are such because they don't produce the enzyme lactase. Some studies suggest that people with IBS are just naturally deficient in enzyme production, though this has not been proven in any way.
Anyway, you get the idea. 
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Re: Enzymes?
