My doctor just recently increased my dose of Effexor from 150mg to 225mg. I increased it gradually by taking 150 + 37.5 for a week and then 150 + 75. Well, now the past couple days I've been real emotional and kind of "down in the dumps". Not sure if it is a side effect of too high of a dose. or if it could be PMS. My tummy is doing great on the higher dose. I requested to increase from 150 because I was feeling "edgy" again and my IBS was flareing up again. But now I'm not sure if it was the right thing to do. I'm going to wait a couple weeks to see if it goes away after I am at that "time of the month". But it would be helpful in knowing if anyone else has experienced this. Thanks.