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FYI

This is kindof complex, however just for the info. It is mainly dealing with Post infectious IBS a sub group of people who develop IBS after a gut infection, say food poisoning or certain bacteria and even a possible virus, and the "Infection" is resolved and leaves changes to the gut, which then develops into IBS.

FYI

This is an expert on Post infectious IBS. This is an excellent article and I am posting a small part on new Probiotic research.

Post-infectious Irritable Bowel Syndrome
Posted 12/08/2005

Robin Spiller; Eugene Campbell

"Anti-inflammatory Effect of Probiotics
Numerous studies have shown an anti-inflammatory effect but the study by McCarthy et al.[30] is of particular interest since it showed a benefit in the interleukin-10-knockout mouse model of colitis using two probiotic bacteria, Lactobillus salivaris and Bifidobacterium infantis, which have since been used in IBS patients (see below). The same group also demonstrated that bacteria did not need to be living to be effective. Nor did they need to be administered orally but could be effective when given subcutaneously,[31] showing that the anti-inflammatory effect is systemic with a generalized decrease in proinflammatory cytokines."

"Anti-inflammatory Treatments in Irritable Bowel Syndrome
With this evidence of low-grade lymphocytosis and inflammatory mediators the idea of treating flares in IBS like an exacerbation of asthma has certain attractions. The first direct trial of prednisolone in PI-IBS was, however, negative.[32] This randomized, double-blind, placebo-controlled trial randomized 29 patients with PI-IBS following C. jejuni enteritis to 3 weeks of oral prednisolone, 30 mg daily. Although mucosal lymphocyte counts fell, enterochromaffin cell numbers did not, nor did bowel symptoms improve significantly. Furthermore, prednisolone was poorly tolerated by IBS patients, indicating that this is unlikely to be a successful treatment. A more subtle and better-tolerated anti-inflammatory effect may be achieved by the use of probiotics. Since inflammation in the bowel appears in many instances to be a reaction to the commensal flora, modifying this by means of probiotics has proved an attractive option given its success in some inflammatory conditions such as ileal pouchitis. There have been several previous studies in IBS with mixed results, but the most recent one used the same two probiotics, L. salivaris and B. infantis, as McCarthy et al..[30] Only B. infantis was demonstrated to improve composite symptom scores as well as abdominal pain, bloating and distension.[33**] Like previous studies, this showed a small improvement in symptoms but, unlike previous studies, they also demonstrated a mechanism by measuring the release of cytokines by peripheral blood lymphocytes. They showed that at baseline IBS patients had a depressed interleukin-10/interleukin-12 ratio and that the active probiotics normalized this ratio. Since interleukin-12 is recognized to be a key proinflammatory cytokine, while interleukin-10 is anti-inflammatory, this imbalance may be important. The study certainly needs repeating, but this is the first study in which alterations in mucosal inflammatory mediators have been demonstrated to relate to improvement in symptoms (for review see)[34]."

"Conclusion
Studies of patients with PI-IBS over the last 2 years have been reviewed which demonstrate low-grade inflammation in the mucosa with increased inflammatory mediators, including serotonin and cytokines. Studies in other IBS groups have also shown increased mast cell numbers and in some cases increased release of mediators such as mast cell protease and histamine. This is plainly an active area in which significant advances with application to clinical practice can be expected in the foreseeable future."

http://www.medscape.com/viewarticle/518355_1

"Post-infective IBS (PI-IBS) develops in 3-30% of individuals with bacterial gastroenteritis. Known risk factors include female sex, severity of initial illness, bacterial toxigenicity and adverse psychological factors, including neuroticism, hypochondriasis, anxiety and depression, as reviewed in 2003.[2] "

also

Clinical-alimentary tract
Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles

"Background & Aims: The aim of this study was to compare the response of symptoms and cytokine ratios in irritable bowel syndrome (IBS) with ingestion of probiotic preparations containing a lactobacillus or bifidobacterium strain. Methods: Seventy-seven subjects with IBS were randomized to receive either Lactobacillus salivarius UCC4331 or Bifidobacterium infantis 35624, each in a dose of 1 � 1010 live bacterial cells in a malted milk drink, or the malted milk drink alone as placebo for 8 weeks. The cardinal symptoms of IBS were recorded on a daily basis and assessed each week. Quality of life assessment, stool microbiologic studies, and blood sampling for estimation of peripheral blood mononuclear cell release of the cytokines interleukin (IL)-10 and IL-12 were performed at the beginning and at the end of the treatment phase. Results: For all symptoms, with the exception of bowel movement frequency and consistency, those randomized to B infantis 35624 experienced a greater reduction in symptom scores; composite and individual scores for abdominal pain/discomfort, bloating/distention, and bowel movement difficulty were significantly lower than for placebo for those randomized to B infantis 35624 for most weeks of the treatment phase. At baseline, patients with IBS demonstrated an abnormal IL-10/IL-12 ratio, indicative of a proinflammatory, Th-1 state. This ratio was normalized by B infantis 35624 feeding alone. Conclusions: B infantis 35624 alleviates symptoms in IBS; this symptomatic response was associated with normalization of the ratio of an anti-inflammatory to a proinflammatory cytokine, suggesting an immune-modulating role for this organism, in this disorder. "

It didn't change stool consistensy though it seems.

http://www.sciencedirect.com/science?_ob=ArticleURL&_ud...06c535bc30bd8adc9d6a

acidophilus is found in yogurt.

Dannon just released a new product.

http://www.activiadannon.com/

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My website on IBS is www.ibshealth.com

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