a new drug for pain and constipation?
#368761 - 12/07/12 04:14 PM
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Cyndy
Reged: 03/05/05
Posts: 1301
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Has anyone seen this article or heard of this drug? Linzess
Is this drug available for IBS yet? If so, I may have a bit of hope just ignited. Please respond. I want to try this, if available. I need to try it!
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The drug Linaclotide ( Linzess ) has been in clinical trials for a few years. It was approved for use with IBS-C in August of this year. You can read about it in Heather's Research Library It is the latest new drug approved for treating IBS-C. Tegaserod was approved for treating IBS-C a few years ago but it was removed from the market due to cardio-vascular side-effects.
Linaclotide is used for individuals with chronic C or IBS-C. IBS-C is defined as
Recurrent abdominal pain or discomfort at least 3 days per month in the last 3 months associated with 2 or more of the following:
– Improvement with defecation
– Onset associated with a change in stool frequency
– Onset associated with a change in stool form (appearance)
1 or more of the following symptoms on at least 25% of occasions for subgroup identification:
- Abnormal stool frequency (less than 3/week)
– Abnormal stool form (lumpy/hard)
– Abnormal stool passage (straining/incomplete evacuation)
– Bloating or feeling of abdominal distension
– Passage of mucous
It is unknown if this drug is more effective than a laxative such as Miralax. If your symptoms match the above criteria and you have fewer than 3 bowel movements a week then you should talk to you GI doctor about prescribing it.
Didn't you say in a previous posting that you were having many bowel movements a day?
Reference
Lacy, Levenick and Crowell (2012) Linaclotide: A Novel Therapy for Chronic Constipation and Constipation-Predominant Irritable Bowel Syndrome Gastroenterology & Hepatology Volume 8, Issue 10 October 2012
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STABLE: ♂, IBS-D 50+ years - Science of IBS
The FODMAP Approach to Managing IBS Symptoms
Evidence-based Dietary Management of Functional GI Symptoms: The FODMAP Approach
FODMAP Chart & Cheatsheet
The Role of Food & Dietary Intervention in IBS
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My main complaint is pain. The article seemed to focus on that aspect of this drug. I would do anything to help the pain. I don't have fewer than 3 bms a week when I take mirialax, but the pain is horribly crippling.
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Look at the FDA's press release. This drug was approved for the treatment of IBS-C. It does say "In IBS-C, it may also help ease abdominal pain". It isn't a general treatment for IBS pain such as that associated with IBS-D.
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STABLE: ♂, IBS-D 50+ years - Science of IBS
The FODMAP Approach to Managing IBS Symptoms
Evidence-based Dietary Management of Functional GI Symptoms: The FODMAP Approach
FODMAP Chart & Cheatsheet
The Role of Food & Dietary Intervention in IBS
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Notify Moderator
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